Patents by Inventor Ian R. Cottingham

Ian R. Cottingham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein C production in non-human transgenic mammals
    Patent number: 5905185
    Abstract: Methods for producing protein C in transgenic non-human mammals are disclosed. The protein C is modified at the two-chain cleavage site between the light and heavy chains of protein C from Lys-Arg to R.sub.1 -R.sub.2 -R.sub.3 -R.sub.4 where R.sub.1 through R.sub.4 are individually Arg or Lys. DNA segments encoding modified protein C are introduced into the germ line of a non-human mammals, and the mammal or its female progeny produces milk containing protein C expressed from the introduced DNA segments. The protein C expressed from the introduced DNA segments has anticoagulant activity when activated. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous protein C are also disclosed.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: May 18, 1999
    Assignees: PPL Therapeutics, ZymoGenetics, Inc.
    Inventors: Ian Garner, Ian R. Cottingham, Simon M. Temperley, Donald C. Foster, Cindy A. Sprecher, Donna E. Prunkard