Abstract: Alarm systems, wireless alarm devices, and article security methods are described according to some aspects of the disclosure. In one aspect, an alarm system includes a base communication device, a remote communication device configured to communicate with the base communication device, wherein the remote communication device is adapted to be associated with an article to be secured and wherein the remote communication device comprises alarm circuitry, and wherein the remote communication device is configured to generate a reference signal comprising a plurality of identifiable components corresponding to communications intermediate the base communication device and the remote communication device and to control the alarm circuitry to generate a human perceptible alarm responsive to detection of the presence of the plurality of identifiable components in the reference signal.

Abstract: Alarm systems, wireless alarm devices, and article security methods are described according to some aspects of the disclosure.

Abstract: Alarm systems, remote communication devices, and article security methods are described according to some aspects of the disclosure. In one aspect, an article security method includes associating a remote communication device with an article to be secured; using the remote communication device, generating a plurality of electrical signals responsive to receipt of spurious electromagnetic energy and a plurality of wireless signals of a base communication device associated with the remote communication device to form an alarm system; distinguishing the electrical signals generated responsive to the spurious electromagnetic energy from electrical signals generated responsive to the wireless signals of the base communication device; and responsive to the distinguishing, generating a plurality of human perceptible alarm signals corresponding to respective ones of the electrical signals generated responsive to the wireless signals of the base communication device.

Abstract: Alarm systems, remote communication devices, and article security methods are described according to some aspects of the disclosure. In one aspect, an article security method includes associating a remote communication device with an article to be secured; using the remote communication device, generating a plurality of electrical signals responsive to receipt of spurious electromagnetic energy and a plurality of wireless signals of a base communication device associated with the remote communication device to form an alarm system; distinguishing the electrical signals generated responsive to the spurious electromagnetic energy from electrical signals generated responsive to the wireless signals of the base communication device; and responsive to the distinguishing, generating a plurality of human perceptible alarm signals corresponding to respective ones of the electrical signals generated responsive to the wireless signals of the base communication device.

Abstract: Alarm systems, remote communication devices, and article security methods are described according to some aspects of the disclosure. In one aspect, an article security method includes associating a remote communication device with an article to be secured; using the remote communication device, generating a plurality of electrical signals responsive to receipt of spurious electromagnetic energy and a plurality of wireless signals of a base communication device associated with the remote communication device to form an alarm system; distinguishing the electrical signals generated responsive to the spurious electromagnetic energy from electrical signals generated responsive to the wireless signals of the base communication device; and responsive to the distinguishing, generating a plurality of human perceptible alarm signals corresponding to respective ones of the electrical signals generated responsive to the wireless signals of the base communication device.

Abstract: Alarm systems, wireless alarm devices, and article security methods are described according to some aspects of the disclosure.

Abstract: A programmable key for use in a security system for protecting items of merchandise has a housing, a power supply mounted in the housing, a logic control circuit which includes a controller, a wireless communication circuit and a security disarm code (SDC) memory. The key has visual indicators such as an LED which is operatively connected to the logic control circuit and pulsed to indicate the state of the SDC. The control circuit includes a timer which has a preset time limit programmed therein, which invalidates the stored SDC if not refreshed by a remote programming source within a certain time period. The logic circuit further includes a counter which counts the number of activations of a control switch, and which permanently deactivates the control circuit upon reaching a certain count value to ensure that the internal battery has sufficient power to maintain the key operational. The wireless communication circuit preferably is infrared (IR) or radio frequency (RF) controlled.

Abstract: Alarm systems, wireless alarm devices, and article security methods are described according to some aspects of the disclosure. In one aspect, an alarm system includes a base communication device, a remote communication device configured to communicate with the base communication device, wherein the remote communication device is adapted to be associated with an article to be secured and wherein the remote communication device comprises alarm circuitry, and wherein the remote communication device is configured to generate a reference signal comprising a plurality of identifiable components corresponding to communications intermediate the base communication device and the remote communication device and to control the alarm circuitry to generate a human perceptible alarm responsive to detection of the presence of the plurality of identifiable components in the reference signal.

Abstract: Methods are described using a particular type of assay system, the Multi-Pathway High Throughput Assay, in conjunction with a novel experimental strategy, whereby repeated cycles of experiments result in the identification of the most effective synergistic combinations of potential active agents from a library of materials. The novel experimental strategy not only requires far fewer total experiments than would be required using conventional discovery strategies but also maximizes the probability of finding highly synergistic combinations through the principle of multiple-pathway intervention.

Abstract: The method employs a piece of skin of area greater than 1 cm2 cultured under conditions that maintain its viability and substantially normal structure for sufficient time for topically applied test material to potentially exert an effect. The skin includes the majority of the epidermal layer plus an appropriate amount of supporting dermis. The surface of the skin is partitioned by a surface barrier film into a pattern of isolated regions to which different test materials can be subsequently topically applied in such a way that they do not significantly migrate around the edges of the skin into the culture medium. The effect of the topically applied material on the skin is determined using an appropriate method. In a variant of the method, the temperature of the culture system is maintained at or below about 30° C. to improve the skins viability and maintain a substantially normal structure. The invention encompasses effective topically applied materials identified using the methods described herein.

Abstract: A security system for protecting items of merchandise includes a programmable key, a programming station for generating a security disarm code (SDC) into the key, and a security device attached to the item of merchandise. The security device is initially programmed with the SDC from the key and is subsequently disarmed by the key upon matching the SDC of the key with the SDC stored in the security device. A wireless interface is provided in the programming station, programmable key and security device for programming the SDC into the key and for matching the SDC of the key with the SDC of the alarm module. An internal timer in the key invalidates the SDC in the key after a predetermined time period to prevent use of the key for disarming a security device after the time period has expired. The programming station initially generates a unique SDC which remains in the programming station for use with the programmable keys and alarm modules.

Abstract: A theft deterrent tag includes a first tag element having a post and a second tag element for receiving the post to secure the tag elements together on an item of merchandise. Spaced electrical contacts within the second tag element receive therebetween the post, which abuts each of the electrical contacts to provide an electrical pathway between the contacts to close a first electrical circuit which turns the device on. The first tag element includes a head which depresses a plunger switch to arm the device. The device is configured to sound an onboard alarm in response to prying of the head or cutting of the post of the first tag element, or if an EAS tag receives a wireless signal from a security gate. Security gate alarms also sound if the tag moves through the gate or within a predetermined distance thereof.

Abstract: A security alarm module for attaching to an item of merchandise in a security system for protecting the item of merchandise has a housing, a logic control circuit including a central controller, a wireless interface for communicating with a programmable key containing a security code, and a memory circuit for storing the security code. An attachment device attaches the alarm module to the item of merchandise and a sense loop operatively communicates with the attachment device for sensing when the integrity of the attachment device is compromised. An audio alarm is located within the housing and is actuated when the integrity of the sense loop is compromised. A visual indicator such as an LED, indicates the status of the alarm module. The housing includes a base and a bottom housing member which is spaced from the base to form a sound region. The audio alarm is mounted in the bottom housing member and communicates with the sound region which enhances the sound level of the alarm when actuated.

Abstract: A programming apparatus for generating and retaining a security disarm code (SDC) for use in a security system for protecting items of merchandise has a housing and a logic control circuit located within the housing. The control circuit includes a controller for generating the SDC, a memory for storing the generated SDC and a wireless communication system for interfacing with a programmable key used for operating a security device attached to an item of merchandise. A visual display includes a plurality of LEDs which indicate the status of the logic control circuit. The SDC is generated initially as a random SDC by the programming apparatus, which SDC is retained in the controller of the apparatus for the life of the programming apparatus.

Abstract: Methods are described using a particular type of assay system, the Multi-Pathway High Throughput Assay, in conjunction with a novel experimental strategy, whereby repeated cycles of experiments result in the identification of the most effective synergistic combinations of potential active agents from a library of materials. The novel experimental strategy not only requires far fewer total experiments than would be required using conventional discovery strategies but also maximizes the probability of finding highly synergistic combinations through the principle of multiple-pathway intervention.

Abstract: Fatty acid amides, but not free fatty acids or fatty acid esters, in combination with either retinol or retinyl ester resulted in a synergistic enhancement in keratinocyte proliferation and synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in combination with fatty acid amides were analogous to treatment with retinoic acid.

Abstract: A composition for topical application to skin which comprises:(i) from 0.0001 to 10% by weight of one or more ceramide pathway intermediates or precursors thereof and mixtures thereof; and(ii) a balancing amount of a cosmetically acceptable vehicle for the intermediate.

Abstract: Dimethyl imidazolidinone in combination with either retinol or retinyl ester resulted in a synergistic enhancement in keratinocyte proliferation and synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in combination with dimethyl imidazolidinone were analogous to treatment with retinoic acid.

Abstract: A sunscreen composition for application to human skin comprises an ultraviolet absorber which is introduced as an anion into a layered double hydroxide of the general formula[N.sub.m N.sub.n (OH).sub.2(m+n) ].sup.y+ X.sup.x-.sub.y/x .multidot.zH.sub.2 Owhere M is a divalent metal or lithium, N is a trivalent metal and X denotes anions present as an interlayer between layers of metal atoms joined through the OH groups.Such layered double hydroxides are, for this invention, suspended in a cosmetically acceptable vehicle.

Abstract: A method of synthesis of .omega.-hydroxy fatty acid containing ceramides having the general structure (1). ##STR1## where A represents CH.sub.2 or --CH.dbd.CH--Y represents a residue of a C.sub.14 to C.sub.22 fatty acid having the structure (2) ##STR2## where Z is --OH or an epoxy oxygenx is an integer of from 12 to 20y is an integer of from 20 to 40z is 0 or an integer of from 1 to 4a is an integer of from 8 to 50b is an integer of from 10 to 100and n is an integer of from 7 to 27.