Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Abstract: Barriers for flood defense and other purposes are often constructed using sand bags. The strength of these barriers is limited and the invention seeks to address this problem. The invention provides a tie formed as a single injection moulded item placed between layers of sandbags to help to hold them together. The tie has two rigid triangular end plates (4) and (5) linked by a flexible arm (11). The end plates are formed with protruding spikes (6) shaped with a barb so that they will easily penetrate the fabric of a sandbag but are difficult to pull out. In use, each tie is placed between layers of sandbags so that spikes of respective plates (4) and (5) become anchored to adjoining bags. The bags of the barrier are thus held together and any irregularities in it are accommodated by the flexibility of the arm (11). Slots (14) and lugs (15) allow a plurality of ties to be linked together as may be required when oversize sandbags are employed.

Abstract: Barriers for flood defense and other purposes are often constructed using sand bags. The strength of these barriers is limited and the invention seeks to address this problem. The invention provides a tie formed as a single injection moulded item placed between layers of sandbags to help to hold them together. The tie has two rigid triangular end plates (4) and (5) linked by a flexible arm (11). The end plates are formed with protruding spikes (6) shaped with a barb so that they will easily penetrate the fabric of a sandbag but are difficult to pull out. In use, each tie is placed between layers of sandbags so that spikes of respective plates (4) and (5) become anchored to adjoining bags. The bags of the barrier are thus held together and any irregularities in it are accommodated by the flexibility of the arm (11). Slots (14) and lugs (15) allow a plurality of ties to be linked together as may be required when oversize sandbags are employed.

Abstract: Barriers for flood defense and other purposes are often constructed using sand bags. The strength of these barriers is limited and the invention seeks to address this problem. The invention provides a tie formed as a single injection molded item placed between layers of sandbags to help to hold them together. The tie has two rigid triangular end plates (4) and (5) linked by a flexible arm (11). The end plates are formed with protruding spikes (6) shaped with a barb so that they will easily penetrate the fabric of a sandbag but are difficult to pull out. In use, each tie is placed between layers of sandbags so that spikes of respective plates (4) and (5) become anchored to adjoining bags. The bags of the barrier are thus held together and any irregularities in it are accommodated by the flexibility of the arm (11). Slots (14) and lugs (15) allow a plurality of ties to be linked together as may be required when oversize sandbags are employed.

Abstract: A delivery system for a medicament or well-being enhancing composition, comprising a flexible member, means for attaching the flexible member to fabric to form a pocket and an absorbent pad for impregnation with the medicament or well-being enhancing composition arranged such that when the flexible member is attached to a piece of fabric a pocket is formed shaped and sized such the pad may be received and held securely within the pocket but is removable therefrom. The fabric is typically part of a garment or bed-linen.

Abstract: A delivery system for a medicament or well-being enhancing composition, comprising a flexible member, means for attaching the flexible member to fabric to form a pocket and an absorbent pad for impregnation with the medicament or well-being enhancing composition arranged such that when the flexible member is attached to a piece of fabric a pocket is formed shaped and sized such the pad may be received and held securely within the pocket but is removable therefrom. The fabric is typically part of a garment or bed-linen.