Patents by Inventor Ian Stansfield

Ian Stansfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral indoles
    Patent number: 7781422
    Abstract: Compounds of the formula (I): wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: August 24, 2010
    Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA
    Inventors: Ian Stansfield, Uwe Koch, Joerg Habermann, Frank Narjes
  • Antiviral indoles
    Patent number: 7767660
    Abstract: Compounds of the formula (I): wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: August 3, 2010
    Assignee: Istituto di Richerche di Biologia Molecolare P. Angeletti SpA
    Inventors: Ian Stansfield, Uwe Koch, Joerg Habermann, Frank Narjes
  • BENZOFURAN-CARBOXAMIDE DERIVATIVES AS ANTIVIRAL AGENTS
    Publication number: 20100120760
    Abstract: A compound of the formula (I): as defined herein, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing a compound of the formula (I) for use in inhibiting hepatitis C virus polymerase and/or of treating or preventing an illness due to hepatitis C virus,
    Type: Application
    Filed: March 25, 2008
    Publication date: May 13, 2010
    Applicant: ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANG
    Inventors: Uwe Koch, Angela Claire Mackay, Frank Narjes, Ian Stansfield
  • Antiviral Indoles
    Publication number: 20100076046
    Abstract: Compounds of the formula (I) wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed.
    Type: Application
    Filed: December 19, 2007
    Publication date: March 25, 2010
    Applicant: Istituto di Ricerche di Biologia Molecolare P. Angeletti SPA
    Inventors: Ian Stansfield, Uwe Koch, Joerg Habermann, Frank Narjes
  • Tetracyclic indole derivatives as antiviral agents
    Patent number: 7662809
    Abstract: The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, R14, R15, A, Ar, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: February 16, 2010
    Assignee: Istituto di Richerche di Biologia Molecolare P Angeletti SpA
    Inventors: Caterina Ercolani, Joerg Habermann, Frank Narjes, Simona Ponzi, Michael Rowley, Ian Stansfield
  • Pentacyclic Indole Derivatives as Antiviral Agents
    Publication number: 20100009959
    Abstract: The present invention relates to pentacyclic indole derivatives of formula (I): wherein A, Ar, R1, R2, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
    Type: Application
    Filed: May 4, 2007
    Publication date: January 14, 2010
    Applicant: Instituto di Ricerche di Biologia Molecolare P. Angeletti SPA
    Inventors: Elena Capito, Joerg Habermann, Frank Narjes, Maria del Rosario Rico Ferreira, Ian Stansfield
  • Tetracyclic Indole Derivatives as Antiviral Agents
    Publication number: 20090149526
    Abstract: The present invention relates to tetracyclic indole derivatives of formula (I): wherein Ar, A, R1, R2, L, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
    Type: Application
    Filed: September 1, 2006
    Publication date: June 11, 2009
    Inventors: Frank Narjes, Ian Stansfield
  • Tetracyclic Indole Derivatives as Antiviral Agents
    Publication number: 20090136449
    Abstract: The present invention relates to tetracyclic indole derivatives of formula (I); wherein Ar, D1, D2, D3, D4, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
    Type: Application
    Filed: November 9, 2006
    Publication date: May 28, 2009
    Inventors: Marcello Di Filippo, Steven Harper, Frank Narjes, Barbara Pacini, Alessia Petrocchi, Michael Rowley, Ian Stansfield
  • Modulators of hcv replication
    Publication number: 20090069344
    Abstract: The present invention is directed to compounds of formula (I): where X, Y, R1, R2 and R3 are defined therein, which can act as modulators of viral replication and/or virus production, especially of the hepatitis C virus (HCV).
    Type: Application
    Filed: September 29, 2005
    Publication date: March 12, 2009
    Inventors: Immacolata Conte, Caterina Ercolani, Claudio Giuliano, Giovanni Migliaccio, Ian Stansfield, Gessica Filocamo, Veronica Suriano
  • Therapeutic compounds
    Publication number: 20090048239
    Abstract: A class of macrocyclic compounds of formula (I), wherein R7, A, Ar, B, D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.
    Type: Application
    Filed: July 15, 2008
    Publication date: February 19, 2009
    Inventors: Immacolata Conte, Joerg Habermann, Angela Mackay, Frank Narjes, Maria del Rosario Rico Ferreira, Ian Stansfield
  • Tetracyclic Indole Derivatives as Antiviral Agents
    Publication number: 20080261938
    Abstract: The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, R14, R15, A, Ar, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
    Type: Application
    Filed: October 25, 2005
    Publication date: October 23, 2008
    Inventors: Caterina Ercolani, Joerg Habermann, Frank Narjes, Simona Ponzi, Michael Rowley, Ian Stansfield
  • Imidazole and Thioazole Derivatives as Antiviral Agents
    Publication number: 20080249146
    Abstract: The present invention relates to compounds of the formula (I), wherein R1, R2, A, B, D, E, F, G and Ar are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.
    Type: Application
    Filed: July 14, 2005
    Publication date: October 9, 2008
    Inventors: Immacolata Conte, Jose Ignacio Martin Hernando, Savina Malancona, Jesus Maria Ontoria Ontoria, Ian Stansfield
  • Antiviral indoles
    Publication number: 20080214522
    Abstract: Compounds of the formula (I): wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed.
    Type: Application
    Filed: December 19, 2007
    Publication date: September 4, 2008
    Applicant: Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA
    Inventors: Ian Stansfield, Uwe Koch, Joerg Habermann, Frank Narjes
  • Antiviral indoles
    Publication number: 20080153895
    Abstract: Compounds of the formula (I): wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use in medicine are disclosed.
    Type: Application
    Filed: December 19, 2007
    Publication date: June 26, 2008
    Applicant: Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA
    Inventors: Ian Stansfield, Uwe Koch, Joerg Habermann, Frank Narjes
  • Peptides and their use as inhibitors of hepatitis C virus ns3 protease
    Patent number: 7119073
    Abstract: Compounds of formula (I), and pharmaceutically acceptable salts and esters thereof: (I); wherein Q, R2, X, Y and Z are as defined herein; are inhibitors of the hepatitis C virus (HCV) NS3 protease
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: October 10, 2006
    Assignee: Istituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA
    Inventors: Stefania Colarusso, Cristina Gardelli, Benjamin Gerlach, Steven Harper, Uwe Koch, Victor Giulio Matassa, Ester Muraglia, Frank Narjes, Jesus Maria Ontoria Ontoria, Alessia Petrocchi, Simona Ponzi, Ian Stansfield, Vicenzo Summa
  • Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors
    Patent number: 7091209
    Abstract: A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatized at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 15, 2006
    Assignee: Merck & Co., Inc.
    Inventors: Cristina Gardelli, Claudio Giuliano, Steven Harper, Uwe Koch, Frank Narjes, Jesus Maria Ontoria Ontoria, Marco Poma, Simona Ponzi, Ian Stansfield, Vincenzo Summa
  • Tetracyclic indole derivatives as antiviral agents
    Publication number: 20060100262
    Abstract: The present invention relates to tetracyclic indole compounds of formula (I): wherein R1, R2, A, Ar, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
    Type: Application
    Filed: October 25, 2005
    Publication date: May 11, 2006
    Inventors: Immacolata Conte, Caterina Ercolani, Frank Narjes, Marco Pompei, Michael Rowley, Ian Stansfield
  • Peptides and their use as inhibitors of hepatitis c virus ns3 protease
    Publication number: 20040142876
    Abstract: Compounds of formula (I), and pharmaceutically acceptable salts and esters thereof: (I); wherein Q, R2, X, Y and Z are as defined herein; are inhibitors of the hepatitis C virus (HCV) NS3 protease.
    Type: Application
    Filed: March 3, 2004
    Publication date: July 22, 2004
    Inventors: Stefania Colarusso, Cristina Gardelli, Benjamin Gerlach, Steven Harper, Uwe Koch, Victor Giulio Matassa, Ester Muraglia, Frank Narjes, Jesus Maria Ontoria Ontoria, Alessia Petrocchi, Simona Ponzi, Ian Stansfield
  • Dihydroxypyrimidine carboxylic acids as viral polymerase inhibitors
    Publication number: 20040106627
    Abstract: A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclic group; as well as compounds of formula (I) which are derivatised at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme.
    Type: Application
    Filed: July 9, 2003
    Publication date: June 3, 2004
    Inventors: Cristina Gardelli, Claudio Giuliano, Steven Harper, Uwe Koch, Frank Narjes, Jesus Maria Ontoria Ontoria, Marco Poma, Simona Ponzi, Ian Stansfield, Vincenzo Summa