Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation.

Abstract: An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation.

Abstract: An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation.

Abstract: This invention relates to conveyor guides comprising conveyor guide rail units, such as those used on automated handling lines where containers of different sizes are processed. One or more guide rails are employed to the sides of the conveyor guide to ensure that articles follow a desired path. This invention provides an adjustable conveyor guide rail unit that comprises a guide member operable to be set in a plurality of discrete positions, thereby allowing the width of a channel through which an article may be conveyed to be varied. Width adjustment is effected by adjusting a rotatable tab to align one of a number of holes with a pin provided on the guide rail. With the pin received in a hole, the guide rail is secured in a desired setting.

Abstract: This invention relates to conveyor guides comprising conveyor guide rail units, such as those used on automated handling lines where containers of different sizes are processed. One or more guide rails are employed to the sides of the conveyor guide to ensure that articles follow a desired path. This invention provides an adjustable conveyor guide rail unit that comprises a guide member operable to be set in a plurality of discrete positions, thereby allowing the width of a channel through which an article may be conveyed to be varied. Width adjustment is effected by adjusting a rotatable tab to align one of a number of holes with a pin provided on the guide rail. With the pin received in a hole, the guide rail is secured in a desired setting.

Abstract: A blister sheet (1) has a generally rectangular blister (2) formed with one pair of longer side walls (7) having parallel steps (8) and a second pair of shorter side wall (9) devoid of steps. The side walls serve to space a front face (5) of the blister from the plane of a rupturable foil backing sheet (4) which retains medication doses (nor shown) inside the blister until they are to be taken. The medication doses are ejected from the cavity of the blister (2) by depressing its front face with finger pressure so that they are forced against the backing sheet (4) with sufficient force to rupture it. During the application of finger pressure to the front face (5) it bows downwardly in its central region as indicated by the broken outline. Simultaneously the end walls (9) tilt inwardly towards one another so that any medication doses lying against them are forced into the central region of the blister from which they can be ejected more easily by the descending front face (5).

Abstract: A holder (100) for storing prescribed medication doses in a sealed cup (112) is provided with a sealing strip (117) a first portion (110) of which covers the mouth of the cup and a second portion (120) carries a picture of the face of the patient for whom the medication has been prescribed. The holder (100) is provided with a rim (113) extending outwardly from the mouth of the cup and with an extension flange (114) having a flat upper surface (111) which is coplanar with the upper surface of the rim (113). The sealing strip adheres to the coplanar surfaces of the rim (113) and the flange (114) and is provided with lines of severance (130 and 131) extending from a pull-tab (151) and along opposite sides of the cup. These lines of severance (130 and 131) are arranged within the confines of the path of the seal between the sealing strip (117) and the rim (113) so that air cannot leak through the lines of severance and into the cup when storing medication doses within the holder.

Abstract: A blister sheet (1) has a generally rectangular blister (2) formed with one pair of longer side walls (7) having parallel steps (8) and a second pair of shorter side wall (9) devoid of steps. The side walls serve to space a front face (5) of the blister from the plane of a rupturable foil backing sheet (4) which retains medication doses (nor shown) inside the blister until they are to be taken. The medication doses are ejected from the cavity of the blister (2) by depressing its front face with finger pressure so that they are forced against the backing sheet (4) with sufficient force to rupture it. During the application of finger pressure to the front face (5) it bows downwardly in its central region as indicated by the broken outline. Simultaneously the end walls (9) tilt inwardly towards one another so that any medication doses lying against them are forced into the central region of the blister from which they can be ejected more easily by the descending front face (5).

Abstract: An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation.

Abstract: A holder (100) for storing prescribed medication doses in a sealed cup (112) is provided with a sealing strip (117) a first portion (110) of which covers the mouth of the cup and a second portion (120) carries a picture of the face of the patient for whom the medication has been prescribed. The holder (100) is provided with a rim (113) extending outwardly from the mouth of the cup and with an extension flange (114) having a flat upper surface (111) which is coplanar with the upper surface of the rim (113). The sealing strip adheres to the coplanar surfaces of the rim (113) and the flange (114) and is provided with lines of severance (130 and 131) extending from a pull-tab (151) and along opposite sides of the cup. These lines of severance (130 and 131) are arranged within the confines of the path of the seal between the sealing strip (117) and the rim (113) so that air cannot leak through the lines of severance and into the cup when storing medication doses within the holder.

Abstract: Novel multi-component insect lures comprising (3Z,6Z)-dodecadien-12-olide and 13-methyl-(5Z,8Z)-tetradecadien-13-olide together with a fungal volatile selected from the group consisting of 1-octen-3-ol and 3-methylbutanol, wherein the amount of 11-methyl-(3Z,6Z)-dodecadien-11-olide in the composition is substantially zero, and a novel method for production of these pheromones, whereby the cost of active components may be reduced to economically advantageous levels. The lures are particularly effective in attracting saw-toothed grain beetles of group Coleoptera, Cucujidae, particularly species Oryzaephilus surinamensis.