Abstract: Compounds of general formula and their use in the treatment of psychotic disorders and cognitive impairment, are disclosed.

Abstract: A method and system for documenting processes and controls of an organization involve storing information describing the processes of the organization in a database and then accessing the database with a suitable user interface application. Preferably the user interface application is a web browser and the data in the database is provided to users as a series of web pages. Using the user interface application, users can review the documented processes, report errors, request changes, generate reports, and so forth. Users with suitable access privileges can modify the data in the database using the user interface application. An external auditor can audit the processes and controls of the organization from his own office by accessing the database over a network such as the Internet.

Abstract: A nebulizer (1) comprises one or more removable components (5,7,9,13), for example a mesh assembly (9), mouthpiece, plunger assembly (7) and medication chamber (13), each having an associated data carrier (5a, 7a, 9a). The data carrier (5a, 7a, 9a) can be used to store information indicating the type of removable component (5,7,9,13) that is fitted to the nebulizer (1). A removable component (5,7,9,13) may be from a set of such removable components. For example, a mouthpiece (5) fitted to the nebulizer (1) may be from a set of mouthpieces having different flow rates. The data carrier (5a, 7a, 9a) may also be used to control operation of the nebulizer (1). A data carrier (9a) attached to a mesh (9) may be used to prevent the nebulizer (1) from being used when the mesh (9) has been used a predetermined number of times.

Abstract: An apparatus (10) and method to aid in administering inhaled pharmaceutical aerosol to a patient is configured to maintain a tongue in proper position and offset the patients upper and lower jaws during aerosol delivery. An adjustable member (26) is provided adjacent a mouthpiece and at least partially surrounds and moves with respect to the body of the apparatus. The adjustable member has a step structured (32, 34) to impart a selected amount of mandibular advancement to a patient during aerosol delivery. A tongue depressor (40) which may be integrally formed with the adjustable member configured to prevent a tongue from occluding a flow of aerosol is also provided.

Abstract: A medication delivery apparatus (5) includes a reservoir for holding a liquid medication and a metering device (25) coupled to the reservoir for supplying a dose of the liquid medication to the reservoir. The metering device includes an upper chamber, a lower chamber coupled to the upper chamber, a piston selectively moveable within the upper chamber and the lower chamber and a valve providing selective fluid communication between the lower chamber and the reservoir in response to movement of the piston.

Abstract: A method and system for documenting processes and controls of an organization involve storing information describing the processes of the organization in a database and then accessing the database with a suitable user interface application. Preferably the user interface application is a web browser and the data in the database is provided to users as a series of web pages. Using the user interface application, users can review the documented processes, report errors, request changes, generate reports, and so forth. Users with suitable access privileges can modify the data in the database using the user interface application. An external auditor can audit the processes and controls of the organization from his own office by accessing the database over a network such as the Internet.

Abstract: A compound of the formula (I): wherein R1, R2, R3, R4, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are their use in medicine, for example in the treatment of schizophrenia.

Abstract: A computer readable storage medium comprises executable instructions to provide a Graphical User Interface for displaying visualizations of a multi-dimensional database. An action is received within a visualization of a table of the multi-dimensional database, the action performed by a user when selecting a cell of the table. A slice in the visualization is populated in response to the action. The visualization is filtered to drill down on dimensions associated with the cell.

Abstract: Compounds of formula (I), salts and solvates are provided: Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: A surface inspection system, as well as related components and methods, are provided. The surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The system features a variable polarization a polarizing relay assembly arranged to selectively permit the scattered light having a selected polarization orientation to pass along a detector optical axis to a light detection unit in the detection subsystem. The system also features a collector output width varying subsystem for varying the width of an output slit in response to changes in the location of the location scanned on the workpiece.

Abstract: A sealing structure for an optical device, such as an image intensifier device, is provided. The optical device includes an evacuated housing and an anode positioned within the evacuated housing. An interior sealing member extends from the anode. An exterior sealing member extends from a component of the image intensifier device, wherein the exterior sealing member is positioned to extend adjacent to and substantially parallel with the interior sealing member such that a gap is defined between the sealing members. A seal cup is positioned for sealing engagement with both the interior sealing member and the exterior sealing member to substantially maintain a vacuum condition within the housing.

Abstract: The invention presented here is an add-in part designed for the M4 and similar commercial AR-15 rifle variants or any other weapon using an adjustable multi position receiver extension based on the M4 pattern. Its purpose is to be installed in the longitudinal adjustment slot of the receiver extension tube limiting the buttstock's maximum extension travel to a preselected position.

Abstract: The invention of the present application relates to an apparatus to aid in administering inhaled pharmaceutical aerosol to a patient. The apparatus is used in conjunction with an aerosol delivery device. The apparatus comprises steps on the top and bottom of the apparatus, which when used aid the patient causes mandibular advancement, and opening of the mouth, causing opening of patient's airway, resulting in improved aerosol lung deposition. The invention also relates to a method of using such apparatus in a combination with an aerosol delivery device or a system, and to the mouthpiece of said apparatus.

Abstract: Compounds of formula (I) and salts thereof are provided: wherein R4, R5, R6, Q, A, and Y are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

Abstract: High aspect ratio micromachined structures in semiconductors are used to improve power density in Betavoltaic cells by providing large surface areas in a small volume. A radioactive beta-emitting material may be placed within gaps between the structures to provide fuel for a cell. The pillars may be formed of SiC. In one embodiment, SiC pillars are formed of n-type SiC. P type dopant, such as boron is obtained by annealing a borosilicate glass boron source formed on the SiC. The glass is then removed. In further embodiments, a dopant may be implanted, coated by glass, and then annealed. The doping results in shallow planar junctions in SiC.

Abstract: High aspect ratio micromachined structures in semiconductors are used to improve power density in Betavoltaic cells by providing large surface areas in a small volume. A radioactive beta-emitting material may be placed within gaps between the structures to provide fuel for a cell. The pillars may be formed of SiC. In one embodiment, SiC pillars are formed of n-type SiC. P type dopant, such as boron is obtained by annealing a borosilicate glass boron source formed on the SiC. The glass is then removed. In further embodiments, a dopant may be implanted, coated by glass, and then annealed. The doping results in shallow planar junctions in SiC.

Abstract: A feeder for a machine for canning tuna and similar food products includes a feeding device with conveyor belts. The feeding device is suitable to feed tuna loins towards the conveyor belt of the canning machine and to shape the loins into loins having a set thickness. An outlet mouth is located at the end of the belts, together with a knife adjacent to the mouth and suitable to separate the portion of loin projecting through the latter. A mobile wall located opposite the outlet mouth is also provided, as well as a mobile shovel suitable to move the newly formed tuna pat perpendicularly in the direction of motion of the conveyor belt of the canning machine.

Abstract: A feeder for a machine for canning tuna and similar food products includes a feeding device with conveyor belts. The feeding device is suitable to feed tuna loins towards the conveyor belt of the canning machine and to shape the loins into loins having a set thickness. An outlet mouth is located at the end of the belts, together with a knife adjacent to the mouth and suitable to separate the portion of loin projecting through the latter. A mobile wall located opposite the outlet mouth is also provided, as well as a mobile shovel suitable to move the newly formed tuna pat perpendicularly in the direction of motion of the conveyor belt of the canning machine.

Abstract: An economical and simple method of producing para-menthane-3,8-diol in relatively high yield is disclosed. The product is useful as a repellent against noxious insects and other arthropods.

Abstract: A machine for canning tuna and similar food products comprises a conveyor belt feeder, a plurality of dosing chambers aligned with the feeder and formed in a rotor rotatable in a plane perpendicular to the feed direction, a mouth connecting the feeder to the dosing chambers, a blade to separate the product introduced in the dosing chambers from the bulk of fed product so as to obtain product cakes, shaping means suitable to shape the cakes into the desired shape and transferring means arranged at a second station reachable through a partial rotation of the rotor to transfer the shaped cakes into the cans carried by another rotor. The connecting mouth has a cross-section of substantially constant shape and the shaping is performed in the dosing chambers by shapers radially mobile along the arms of the rotor when the dosing chambers are still aligned with the feeder.