Patents by Inventor Ian WADDELL

Ian WADDELL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG
    Patent number: 10239843
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: March 26, 2019
    Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Alison E. McGonagle, Allan Jordan, Bohdan Waszkowycz, Colin Hutton, Ian Waddell, James R. Hitchin, Kate Mary Smith, Niall M. Hamilton
  • 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG
    Publication number: 20180016242
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Application
    Filed: December 11, 2015
    Publication date: January 18, 2018
    Inventors: Alison E. MCGONAGLE, Allan JORDAN, Bohdan WASZKOWYCZ, Colin HUTTON, Ian WADDELL, James R. HITCHIN, Kate Mary SMITH, Niall M. HAMILTON