Abstract: The present invention provides a method of treating autoimmune diseases. In particular, it provides a method for the treatment of ulcerative colitis comprising administering to a subject a therapeutically effective amount of a pharmaceutical formulation comprising an antibody, wherein said antibody binds to CD3.

Abstract: Nanoparticles are prepared from a colloidal system comprising a continuous phase and micelles, the micelles comprising surfactant material. A microemulsion is formed by admixing the colloidal system with a solution of an active material, such as a medicament, dissolved in a solvent wherein the solution forms a disperse phase with the micelles of surfactant material. At least the dispersed phase is quenched to a solid state and the continuous phase and solvent are removed to produce the nanoparticles. The nanoparticles can be incorporated in an aerosol composition suitable for deep lung delivery by means of a metered dose inhaler.

Abstract: A turbocharged diesel engine is described. The engine has a two stage turbocharger assembly including low pressure turbochargers coupled and parallel and arranged in series with a single high pressure turbocharger. This allows all turbochargers to be of comparable dimensions for interchangeability of parts. The turbochargers may be mounted on an enclosure which encloses the turbines and the exhaust gas duct work which communicates with the exhaust pipe to insure that any leaking exhaust gas escapes to the atmosphere via the exhaust pipe. A cartridge is also described which contains the moving parts which can be removed without disturbing the turbine housing.

Abstract: A turbocharged diesel engine has a two-stage turbocharger assembly comprising two low-pressure turbochargers coupled in parallel arranged in series with a single high-pressure turbocharger. This allows all turbochargers to be of comparable dimensions and allows for interchangeability of parts. The turbochargers may be mounted on an enclosure which encloses the turbines and the exhaust gas duct work and which communicates with the exhaust pipe to ensure that any leaking exhaust gas escapes to the atmosphere via the exhaust pipe.