Abstract: The present invention relates to a method of treating cognitive impairment in a patient in need thereof by administering Compound (I), a stimulator of soluble guanylate cyclase (sGC) at certain dosages either alone or in combination therapy.

Abstract: An image acquisition and analysis system are disclosed. The system enables high throughput, objective analysis of microbial samples over days or weeks. The system may accommodate upwards of twelve 96- or 384-well plates simultaneously (liquid or solid media). The system may acquire and analyze a large number of samples in a short period of time. For example, over 384 samples per minute or 18,432 samples per hour. The system hardware may include a multi-spectral imager (fluorescence and bright field detection), electro-mechanical assemblies, and an optional high-resolution stage. The system may automate image acquisition, image data processing, simplify data storage, and enable automated analysis tools to significantly reduce the manual labor and time associated with such tasks. The system may allow for quick processing and analysis of data into clear phenotypic classes.

Abstract: Described herein are methods and systems for controlling differential wheel speeds of multi-independent-wheel vehicles, such as four-wheel-drive electric tractors (4WD-ETs). Specifically, a method comprises determining a target speed for each wheel of the vehicle based on at least the steering input. The linear travel speeds (corresponding to these target speeds) of any two wheels are different when the vehicle turns (steering input deviates from a no-steering baseline) or the same when the vehicle travels in a straight line (steering input is at the no-steering baseline). Each target wheel speed is then used to control the rotational speed of the corresponding electric motor, which independently drives one of the vehicle’s wheels. This process of determining the target wheel speeds and independently controlling all electric motors is frequently repeated such that the vehicle can be propelled through the turn at the desired speed with minimal wheel slip.

Abstract: Described herein are swappable battery modules comprising immersion-thermally controlled prismatic battery cells and methods of operating thereof. A module comprises a tubular enclosure attached (e.g., glued) to different surfaces of the cells and forming two fluid channels with one side of the cells and two additional fluid channels with the opposite side. The module also comprises a first end plate, which is attached to the tubular enclosure and comprises two electrical terminals for connecting to an electric vehicle (EV) and/or external charger. The first end plate also comprises a first fluidic port (fluidically coupled with two fluid channels) and a second fluidic port (fluidically coupled to the remaining two fluid channels), both are configured to form fluidic coupling to the electric vehicle and/or the external charger. The module also comprises a second end plate that fluidically interconnects paid fluid channels from different cell sides.

Abstract: Disclosed are systems and methods to bore or tunnel through various geologies in an autonomous or substantially autonomous manner including one or more non-contact boring elements that direct energy at the bore face to remove material from the bore face through the fracture, spallation, and removal of the material. Systems can automatically execute methods to control a set of boring parameters that affect the flux of energy directed at the bore face. Systems can further automatically execute the methods to: monitor, direct, maintain, and/or adjust a set of boring controls, including for example a standoff distance between the system and the bore face, a temperature of exhaust gases directed at the bore face, a removal rate of material from the bore face, and/or a thermal or topological characterization of the bore face during boring operations.

Abstract: Aspects herein are directed to a support garment testing system comprising a torso form having a motion tracking sensor associated with one or more breast structures of the torso form. A support garment is secured to the torso form, and the torso form is mounted on a motion platform that, when actuated, causes displacement of the breast structures. The amount of displacement is measured by the sensor, and the data is used to assign a level of support provided by the support garment.

Abstract: Disclosed are systems and methods to bore or tunnel through various geologies in an autonomous or substantially autonomous manner including one or more non-contact boring elements that direct energy at the bore face to remove material from the bore face through fracture, spallation, and removal of the material. Systems can automatically execute methods to control a set of boring parameters that affect the flux of energy directed at the bore face. Systems can further automatically execute the methods to: monitor, direct, maintain, and/or adjust a set of boring controls, including for example a standoff distance between the system and the bore face, a temperature of exhaust gases directed at the bore face, a removal rate of material from the bore face, and/or a thermal or topological characterization of the bore face during boring operations.

Abstract: Described herein are methods and systems for remote charging of work vehicles using recharge vehicles. A recharge vehicle is equipped with power storage that has a sufficient capacity for propelling the recharge vehicle between a charging station (used for charging the recharge vehicle) and a work location (of the work vehicle) and also for charging the work vehicle at the work location. In some examples, the charging of the work vehicle and even the connection between the vehicles are formed while the work vehicle continues to operate. This approach helps to maximize the operating time of the work vehicle. Furthermore, this approach relaxes the charge rate requirement for charging the recharge vehicle and also for charging the work vehicle as well as the location of the charging station (for charging the recharge vehicle). In some examples, work vehicles and/or recharge vehicles are autonomous vehicles and use vehicle-to-vehicle coordination features.

Abstract: Electric vehicles include adjustable battery positions and/or adjustable track widths for controlling vehicle stability. In some examples, an electric vehicle comprises a positioning mechanism configured to move the battery pack relative to the support structure (e.g., operable as the vehicle's frame) to change the vehicle's COG. The battery pack can be moved in response to other vehicle operations, e.g., COG changes caused by adding/moving loads, changes to the route grade, and the like. The battery pack can be slidably coupled to the support structure. In some examples, an electric vehicle comprises a track adjustment mechanism configured to move the vehicle's wheel axle relative to the support structure, along the wheel axle center axis, thereby changing the track width. The wheel axle can be coupled to a hub motor. In some examples, the battery is moved, and/or the track width is changed during the vehicle's operation.

Abstract: Described herein are methods and systems for controlling differential wheel speeds of multi-independent-wheel vehicles, such as four-wheel-drive electric tractors (4WD-ETs). Specifically, a method comprises determining a target speed for each wheel of the vehicle based on at least the steering input. The linear travel speeds (corresponding to these target speeds) of any two wheels are different when the vehicle turns (steering input deviates from a no-steering baseline) or the same when the vehicle travels in a straight line (steering input is at the no-steering baseline). Each target wheel speed is then used to control the rotational speed of the corresponding electric motor, which independently drives one of the vehicle's wheels. This process of determining the target wheel speeds and independently controlling all electric motors is frequently repeated such that the vehicle can be propelled through the turn at the desired speed with minimal wheel slip.

Abstract: Aspects herein are directed to a support garment testing system comprising a torso form having a motion tracking sensor associated with one or more breast structures of the torso form. A support garment is secured to the torso form, and the torso form is mounted on a motion platform that, when actuated, causes displacement of the breast structures. The amount of displacement is measured by the sensor, and the data is used to assign a level of support provided by the support garment.

Abstract: Described herein are new methods and systems for profiling tunnels. A method comprises moving a shuttle within a shuttle track extending between a boring apparatus (inside a tunnel) and a base station (outside the tunnel). The shuttle is equipped with a movement sensor, which records various movement parameters (e.g., linear and/or angular accelerations) while the shuttle moves within the shuttle track. These movement parameters are then transferred to a tunnel profiler (e.g., a base station) and the profile of the tunnel is determined based on these movement parameters. For example, a shuttle track can be a flexible tube (e.g., continuous or segmented) with the shuttle positioned within the tube. The shuttle can be removed from the tube or remain in the tube while the movement parameters are transferred and, in some examples, while the shuttle is recharged.

Abstract: Disclosed are systems and methods to bore or tunnel through various geologies in an autonomous or substantially autonomous manner including one or more non-contact boring elements that direct energy at the bore face to remove material from the bore face through fracture, spallation, and removal of the material. Systems can automatically execute methods to control a set of boring parameters that affect the flux of energy directed at the bore face. Systems can further automatically execute the methods to: monitor, direct, maintain, and/or adjust a set of boring controls, including for example a standoff distance between the system and the bore face, a temperature of exhaust gases directed at the bore face, a removal rate of material from the bore face, and/or a thermal or topological characterization of the bore face during boring operations.

Abstract: A deployable charging point assembly for a vehicle includes a connecting part for connecting to a supply of electrical power separate from the vehicle. The connecting part is mountable on the vehicle, such that the connecting part is movable relative to a body of the vehicle between a first position and a second position. The charging point assembly is configured to establish an electrical connection between the supply of electrical power and an electrical system of the vehicle when the connecting part is in one or more predetermined positions between the first and second positions.

Abstract: A loading assembly for crimping and loading a prosthetic heart valve into a delivery device includes a loading base, a base funnel, and a compression member. The loading base has a support and a body extending from the support with a recess defined within the body. The recess is configured to receive a substantial portion of the annulus section of the heart valve in an at least partially collapsed condition. The base funnel is configured to be coupled to the loading base and to at least partially collapse the annulus section of the heart valve as it is inserted into the recess in the loading base. The compression member is configured to be coupled to the loading base with the heart valve inserted in the recess for further collapsing the heart valve and loading it into the delivery device.

Abstract: Disclosed are systems and methods to bore or tunnel through various geologies in an autonomous or substantially autonomous manner including one or more non-contact boring elements that direct energy at the bore face to remove material from the bore face through fracture, spallation, and removal of the material. Systems can automatically execute methods to control a set of boring parameters that affect the flux of energy directed at the bore face. Systems can further automatically execute the methods to: monitor, direct, maintain, and/or adjust a set of boring controls, including for example a standoff distance between the system and the bore face, a temperature of exhaust gases directed at the bore face, a removal rate of material from the bore face, and/or a thermal or topological characterization of the bore face during boring operations.

Abstract: Described herein are new methods and systems for profiling tunnels. A method comprises moving a shuttle within a shuttle track extending between a boring apparatus (inside a tunnel) and a base station (outside the tunnel). The shuttle is equipped with a movement sensor, which records various movement parameters (e.g., linear and/or angular accelerations) while the shuttle moves within the shuttle track. These movement parameters are then transferred to a tunnel profiler (e.g., a base station) and the profile of the tunnel is determined based on these movement parameters. For example, a shuttle track can be a flexible tube (e.g., continuous or segmented) with the shuttle positioned within the tube. The shuttle can be removed from the tube or remain in the tube while the movement parameters are transferred and, in some examples, while the shuttle is recharged.

Abstract: Embodiments of the invention are directed toward a geared traction drive system configured to drive a wheel of a vehicle, comprising: a driveshaft for transmitting power to the wheel; an electric drive motor for driving the driveshaft, the electric drive motor configured to receive signals from a vehicle dynamic control system to command a required speed; a gear reduction component for reducing the speed of the motor by a predetermined factor to a lower speed suitable for driving the wheel; and a drive electronics component that works with the electric drive motor to drive the wheel to the speed commanded by the vehicle dynamic control system.

Abstract: Disclosed are systems and methods to bore or tunnel through various geologies in an autonomous or substantially autonomous manner including one or more non-contact boring elements that direct energy at the bore face to remove material from the bore face through fracture, spallation, and removal of the material. Systems can automatically execute methods to control a set of boring parameters that affect the flux of energy directed at the bore face. Systems can further automatically execute the methods to: monitor, direct, maintain, and/or adjust a set of boring controls, including for example a standoff distance between the system and the bore face, a temperature of exhaust gases directed at the bore face, a removal rate of material from the bore face, and/or a thermal or topological characterization of the bore face during boring operations.

Abstract: Methods and systems for securing a data connection for communicating between two end-points are described herein. One of the end-points may be a server and the other of the end-points may be a client that wants to communicate with the server. The data connection may be secured based on a previously-established secure connection and/or a self-signed or self-issued certificate. In some variations, by using the previously-established secure connection and/or a self-signed or self-issued certificate, the secure communication between the server and the client may be conducted without using a third-party authentication service and without requiring a third-party CA to issue a certificate for the server.