Abstract: A probe for use with a sample chamber, the probe including a probing element mounted on an arm, the arm insertable or inserted into the sample chamber to locate the probing element within the sample chamber, a drive mechanism for moving the arm, and a drive control system. Movement of the arm causes movement of the probing element within the sample chamber. The drive control system is for limiting movement of the arm to a specified range, the drive control system programmable to adjust the specified range.

Abstract: The present disclosure relates to a clinical genetic screening assay that designates a subset of high-risk segments within a next generation sequencing (NGS) sample for confirmatory testing. Particularly, aspects are directed towards obtaining (i) regions of interest (ROIs) and associated variant data, (ii) population allele frequency information, and (iii) a sensitivity profile, performing NGS on a sample obtained from a subject to obtain NGS read data for the ROIs, performing a rescue minimization protocol to designate a subset of ROIs for Sanger resequencing, and performing Sanger resequencing on the subset of ROIs. The NGS read data and the Sanger resequencing data are used to generate accurate variant callings and/or diagnosis for the subject.

Abstract: The present invention provides a compound represented by formula (I), a production method thereof, a production intermediate of the same and a method for producing compound B using the compound (I). Compound B is useful as an intermediate for producing compound A that is a BTK inhibitor.

Abstract: A connector adapted for forming a fluid flow pathway therethrough by connection with a reciprocal connector, wherein both the connector and the reciprocal connector each comprise a fluid flow passageway part (11A) defining a fluid flow opening, a socket part (12A) located upon the fluid flow passageway part adjacent to the fluid flow opening, a plug part (13A) located upon the fluid flow passageway part adjacent to the fluid flow opening and spaced from the socket part in a direction crossing the fluid flow opening, wherein the socket part of the connector is configured to receive therein the plug part of said reciprocal connector to connect thereto such that the fluid flow opening of the connector is aligned in register with the fluid flow opening of the reciprocal connector and, a closure part (14A) arranged to openably close the fluid flow opening of the connector and to receive an urging force from said received plug part of the reciprocal connector thereby to be displaced in a direction crossing the flui

Abstract: A method of manufacturing a sensor assembly for an analyte sensor includes, forming a substrate, forming at least one electrode on the substrate, forming an enzymatic layer on the substrate and the at least one electrode, and disabling functionality of at least part of the enzymatic layer while a portion of the enzymatic layer over at least part of the at least one electrode remains active.

Abstract: A particle characterisation instrument is disclosed, comprising: a sample cell, for holding a sample comprising particles suspended in diluent fluid; a light source configured to illuminate the sample with a light beam, thereby producing scattered light from the interaction of the light beam with the particles; a light detector, configured to detect the scattered light and to output scattering data indicative of the diffusion coefficient of the particles in the diluent; a processor, configured to determine a property of the particles from the scattering data; and a temperature sensor, in conductive thermal contact with a wall of the sample cell and at a distance of less than 5 mm from the sample. The processor configured to use the output of the temperature sensor in determining the property of the particles such that the property of the particles determined by the processor is responsive to an output from the temperature sensor.

Abstract: The present application describes a payload management system that routes a payload item associated with an individual from an origin to a destination. In some examples, the payload item is routed from the origin to the destination separate from a travel itinerary associated with the individual. For example, the payload item can be routed via a vehicle other than a VTOL aircraft that is assigned to the individual for a multi-modal transportation service.

Abstract: The present disclosure relates to a positive pressure breathing circuit and a method for ventilating a patient. The breathing circuit can be used in any type of pressurized breathing therapy including, for example, continuous positive air (way) pressure (CPAP) therapy and bilevel positive air pressure therapy where the inspiratory and expiratory pressures differ.

Abstract: A system and method for producing hydrogen wherein the system comprises at least one electrolyzer adapted to be located within a subterranean formation, at least one electrical supply cable having a length selected to extend from the at least one electrolyzer to a ground surface power supply, at least one supply tubing string having a length selected to extend from the at least one electrolyzer to a water supply at the ground surface and at least one collection tubing string having a length selected to extend from the at least one electrolyzer to a collection location at the ground surface. The method comprises providing a well from a surface to an underground formation, locating at least one electrolyzer in the well, supplying the at least one electrolyzer with supply electricity, supplying the at least one electrolyzer with supply water, producing hydrogen gas at the electrolyzer and collecting and transporting the produced hydrogen gas to the surface.

Abstract: One example device, usable in a downhole process, includes a body configured to be removably received in a corresponding recess of a perforation gun, a propellant chamber defined in the body, a projectile chamber defined in the body and positioned in the body above, and in communication with, the propellant chamber, a barrel defined in the body and positioned in the body above, and in communication with, the projectile chamber, and a muzzle defined in the body and positioned in the body above, and in communication with, the barrel.

Abstract: Methods, systems, and storage media for determining potential subject matter conflicts among patent matters are disclosed. Exemplary implementations may: obtain two or more documents associated with patent documents; determine a topical distance between the two or more documents, a first topical distance being the topical distance between the first document and the second document; determine whether the topical distance between the two or more document breaches a threshold, a first threshold being associated with the first topical distance between the first document and the second document; and responsive to a determination that the topical distance breaches the threshold, provide an indication that the threshold was breached.

Abstract: A series of connected vertical contactors arranged horizontally, that are a compact and lower weight boxed arrangement integrated in multiple processing steps to treat engine exhaust to capture carbon dioxide. A direct contact cooler, optional gas scrubber, liquid CO2 absorbent (e.g., amine) absorption and optional water wash are combined in one overall integrated vessel, separated by internal chambers that is organized horizontally to reduce the weight (and cost) of construction through modular, reduced footprint, lower pump heads, with common internal walls and thinner material of constructions.

Abstract: A III-N-based vertical transistor includes a III-N substrate, a source, a drain, and a channel comprising a III-N crystal material and extending between the source and the drain. The channel includes at least one sidewall surface aligned ±0.3° with respect to an m-plane of the III-N crystal material. The III-N-based vertical transistor also includes a gate electrically coupled to the at least one sidewall surface of the channel.

Abstract: Portable, low cost, high speed surface and subsurface vehicles for aquatic data collection, payload delivery, or water quality monitoring. The vehicles can be deployed in pods enable rapid large scale data collection across a wide area. The vehicles are capable of transiting the water surface at speeds of over ten knots, and can also be propelled under the water surface and dive vertically to the floor of the water body. A passive, non-powered internal weight transfer system enhances the vehicle's performance in each of its transit modes. The vehicles can have one or more of the following features: high speed stabilizing wings, a tool-less assembly system, sacrificial standoffs for vertical dives, sacrificial protectors for the control surfaces, and/or a universal mounting system for attaching payloads such as sensors.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for verifying the provenance of a digital object generated by a neural network, such as an image or audio object. Also methods, systems, and apparatus, including computer programs, for training a watermarking neural network and a watermark decoding neural network. The described techniques make efficient use of computing resources and are robust to attack.

Abstract: The present invention relates to an improved apparatus and method for delivering a comestible coating substance and more particularly, though not necessarily, to an improved apparatus for delivering a powder coating to disc-like or disc-shaped or products such as rice cakes, potato crisps/chips, dairy product and crisp/chip-like products in a manufacturing and/or packaging procedure. The present invention seeks to provide an improved system and provides a delivery system that enables first and second major surfaces of the disc-like products to be coated simultaneously.

Abstract: A method of cross-domain policy orchestration may include executing, with a cross-domain automation (CDA) controller, a macro-segmentation of a plurality of domains based at least in part on metadata defining a mapping to a corresponding plurality of domain controllers, and executing, with the CDA controller, a micro-segmentation of policies within a group based at least in part on a merged policy matrix obtained from policies of the domain controllers.

Abstract: The present disclosure relates to a suture anchor assembly that includes a sleeve having an elongated configuration and a tightened configuration. The suture anchor includes a first deployment strand and a second deployment strand that each form a looped end and a free end. The free end of the first deployment strand passes through the looped end of the second deployment strand and the free end of the second deployment strand passes through the looped end of the first deployment strand to form a loose square knot. A portion of the first deployment strand and the second deployment strand pass through the sleeve. Application of tension to each of the free end of the first deployment strand and the free end of the second deployment strand causes the loose square knot to tighten and the sleeve to move to the tightened configuration.

Abstract: In one embodiment, a method includes receiving air into a device that includes an actuator for generating one or more toroidal vortices and determining whether to generate a toroidal vortex for conditioning air in an environment of the device or whether to generate a toroidal vortex for a non-temperature-related functionality. The method further includes generating, based on the determination and by the actuator, one or more toroidal vortices and transmitting, by the device, the one or more toroidal vortices into the environment.

Abstract: A connector adapted for forming a fluid flow pathway therethrough by connection with a reciprocal connector, wherein both the connector and the reciprocal connector each comprise a fluid flow passageway part (11A) defining a fluid flow opening, a socket part (12A) located upon the fluid flow passageway part adjacent to the fluid flow opening, a plug part (13A) located upon the fluid flow passageway part adjacent to the fluid flow opening and spaced from the socket part in a direction crossing the fluid flow opening, wherein the socket part of the connector is configured to receive therein the plug part of said reciprocal connector to connect thereto such that the fluid flow opening of the connector is aligned in register with the fluid flow opening of the reciprocal connector and, a closure part (14A) arranged to openably close the fluid flow opening of the connector and to receive an urging force from said received plug part of the reciprocal connector thereby to be displaced in a direction crossing the flui