Patents by Inventor Iannis Aifantis

Iannis Aifantis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR SENSITIZING CANCER CELLS TO DRUG-INDUCED APOPTOSIS
    Publication number: 20220323376
    Abstract: Disclosed herein are methods of increasing the sensitivity of cancer cells to cell death by an apoptosis-inducing drug. Also disclosed herein are methods of treating cancer in a subject and combination therapeutics.
    Type: Application
    Filed: May 1, 2020
    Publication date: October 13, 2022
    Inventors: Iannis AIFANTIS, Xufeng CHEN, Christina GLYTSOU
  • Methods for treating T-cell acute lymphoblastic leukemia
    Patent number: 10206930
    Abstract: The present invention is directed to methods of treating T-ALL that involve administering an inhibitor of jumonji D3 (JMJD3) demethylase. Another embodiment of the invention relates to methods inhibiting T-ALL cell proliferation and/or survival that involves administering an inhibitor of jumonji D3 (JMJD3) demethylase to a population of T-ALL cells.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: February 19, 2019
    Assignee: New York University
    Inventors: Iannis Aifantis, Panagiotis Ntziachristos
  • Notch agonists for the treatment of cancer
    Patent number: 9683039
    Abstract: The present invention is directed to methods of treating and preventing acute myeloid leukemia and acute myeloid leukemia relapse disease in a subject that involve administering a Notch receptor agonist.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 20, 2017
    Assignee: New York University
    Inventors: Iannis Aifantis, Camille Lobry
  • METHODS FOR TREATING T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
    Publication number: 20170042904
    Abstract: The present invention is directed to methods of treating T-ALL that involve administering an inhibitor of jumonji D3 (JMJD3) demethylase. Another embodiment of the invention relates to methods inhibiting T-ALL cell proliferation and/or survival that involves administering an inhibitor of jumonji D3 (JMJD3) demethylase to a population of T-ALL cells.
    Type: Application
    Filed: August 15, 2016
    Publication date: February 16, 2017
    Applicant: New York University
    Inventors: Iannis AIFANTIS, Panagiotis NTZIACHRISTOS
  • METHODS AND REAGENTS FOR THE DIAGNOSIS AND TREATMENT OF ACUTE LEUKEMIA
    Publication number: 20170035795
    Abstract: The present invention is directed to methods of treating T-ALL that involves administering a therapeutic agent that inhibits a NOTCH-1 regulated non-coding RNA (lncRNA). Another embodiment of the invention relates to methods and kits for diagnosing T-ALL that involve detecting and quantifying the expression level of NOTCH1-regulated lncRNAs is a biological sample from a subject.
    Type: Application
    Filed: August 1, 2016
    Publication date: February 9, 2017
    Applicant: New York University
    Inventors: Iannis AIFANTIS, Thomas TRIMARCHI
  • METHODS OF TREATING ACUTE T CELL LEUKEMIA
    Publication number: 20160354373
    Abstract: The present invention is directed to methods of treating T-cell acute lymphoblastic leukemia. This method involves selecting a subject having T-cell acute lymphoblastic leukemia and administering, to the selected subject, a therapeutic agent that inhibits CXCR4-CXCL12 signaling at a dosage effective to treat the T-cell acute lymphoblastic leukemia in the subject. A method of inhibiting T-cell acute lymphoblastic leukemia cell proliferation and/or survival is also disclosed.
    Type: Application
    Filed: June 6, 2016
    Publication date: December 8, 2016
    Applicant: New York University
    Inventors: Iannis AIFANTIS, Anastasia TIKHONOVA
  • Inhibition of c-Myc ubiquitination to prevent cancer initiation and progression
    Patent number: 9241920
    Abstract: The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of Fbw7 E3 ligase inhibitors to inhibit c-Myc ubiquitination in cancerous cell populations, such as leukemic initiating cell populations, that are responsible for disease initiation and progression.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: January 26, 2016
    Assignee: NEW YORK UNIVERSITY
    Inventors: Iannis Aifantis, Linsey Reavie, Shannon Buckley
  • Leukemic cell CNS infiltration controlled by notch-induced chemotaxis
    Patent number: 9101559
    Abstract: The present invention is directed to methods of preventing central nervous system leukemia, treating T-cell acute lymphoblastic leukemia, and treating immune system disorders associated with CCR7-CCL19 mediated signaling. Suitable therapeutic agents for inhibiting CCR7-CCL19 signaling and methods of identifying additional therapeutic agents useful in the methods of the present invention are also disclosed.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: August 11, 2015
    Assignee: New York University
    Inventors: Iannis Aifantis, Silvia Buonamici
  • NOTCH AGONISTS FOR THE TREATMENT OF CANCER
    Publication number: 20140286955
    Abstract: The present invention is directed to methods of treating and preventing acute myeloid leukemia and acute myeloid leukemia relapse disease in a subject that involve administering a Notch receptor agonist.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: NEW YORK UNIVERSITY
    Inventors: Iannis AIFANTIS, Camille LOBRY
  • INHIBITION OF c-MYC UBIQUITINATION TO PREVENT CANCER INITIATION AND PROGRESSION
    Publication number: 20140288178
    Abstract: The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of Fbw7 E3 ligase inhibitors to inhibit c-Myc ubiquitination in cancerous cell populations, such as leukemic initiating cell populations, that are responsible for disease initiation and progression.
    Type: Application
    Filed: October 29, 2012
    Publication date: September 25, 2014
    Applicant: NEW YORK UNIVERSITY
    Inventors: Iannis Aifantis, Linsey Reavie, Shannon Buckley
  • LEUKEMIC CELL CNS INFILTRATION CONTROLLED BY NOTCH-INDUCED CHEMOTAXIS
    Publication number: 20100285020
    Abstract: The present invention is directed to methods of preventing central nervous system leukemia, treating T-cell acute lymphoblastic leukemia, and treating immune system disorders associated with CCR7-CCL19 mediated signaling. Suitable therapeutic agents for inhibiting CCR7-CCL19 signaling and methods of identifying additional therapeutic agents useful in the methods of the present invention are also disclosed.
    Type: Application
    Filed: May 10, 2010
    Publication date: November 11, 2010
    Applicant: NEW YORK UNIVERSITY
    Inventors: Iannis Aifantis, Silvia Buonamici