Abstract: A system and a method is disclosed for adjusting and/or optimizing a fermentation process performed in one U-loop fermenter, the system including a processor and database for repetitively providing a test value of a fermenter parameter and for repetitively entering the test value of the parameter in the database; wherein the database stores multiple test value entries at various points in time and also stores multiple control value entries at various points in time, wherein the processor performs a mathematical analysis of the test value for providing a calculated test value, and/or the control value for providing at least one calculated control value; and selects, on the basis of the calculated test value and/or on the calculated control value, an adjustment to be introduced into at least one other U-loop fermenter to benefit from the change made in the one U-loop fermenter.

Abstract: The present invention relates to a process for providing a first reaction product by a first fermentation process conducted in a first Loop reactor, the method comprising the steps of: (i) adding an inoculum comprising one or more methanogenic microorganism to the first Loop reactor providing a first inoculated fermentation medium; (ii) adding a gaseous hydrogen (H2) to the first inoculated fermentation medium; (iii) adding a first carbon source to the first inoculated fermentation medium; (iv) allowing the first fermentation medium to ferment, providing the first reaction product; and (v) isolating the first reaction product provided in step (iv).

Abstract: A static mixer or a flow reactor comprising a static mixer for mixing streams of fluid transported through or circulated in a flow reactor is provided. A static mixer element reduces the size of gas bubbles in a liquid for installation in a flow channel, and comprises, a first mixer unit and a second and adjacent mixer unit, which mixer units are displaced relative to each other in the flow direction, such that a through opening in the first mixer unit at least partly faces a surface of the second mixer unit thereby forcing the fluid flow to change direction. Adjacent mixer units have substantially the same height or thickness, and are substantially parallel having a distance between them that may be near zero or up to 10 times the thickness of a mixer unit.

Abstract: The present invention relates to a method for providing a fermentation medium for the cultivation of at least one methanotrophic organism, or for the cultivation of a combination of organisms comprising at least one methanotrophic organism, the method comprises the step of: (i) providing a main growth solution; (ii) optionally sterilizing the main growth solution provided in step (i); (iii) providing a trace metal solution; and (iv) mixing the main growth solution (as provided in step (i) or (ii)) with the trace metal solution provided in step (iii) and providing the fermentation medium for the cultivation of at least one methanotrophic organism, or for the cultivation of a combination of organisms comprising at least one methanotrophic organism.

Abstract: The present invention relates to a process for cultivating one or more microorganisms capable of metabolising methane, the process comprises the steps of: (i) adding a fermentation medium to a fermentation reactor; (ii) adding the one or more microorganism to a fermentation reactor, providing an inoculated fermentation medium, wherein the one or more microorganism does not include a recombinant microorganism; (iii) adding a C1-C5 carbon source, e.g. methane, to the fermentation reactor and/or the inoculated fermentation medium during the fermentation of the one or more microorganisms; and (iv) optionally, adding oxygen to the fermentation reactor and/or the inoculated fermentation medium during the fermentation of the one or more microorganisms, wherein the oxygen is added to the fermentation reactor and/or the inoculated fermentation medium to provide a content of undissolved oxygen in the fermentation reactor and/or a content of gaseous oxygen in an exhaust gas is at most 10% (vol/vol).

Abstract: A fermentation reactor is shown with a loop-part and a top tank, the loop-part having a downflow part, connected to an upflow part via a U-part, wherein the top tank includes: (i) a first outlet connecting the top tank to the downflow part of the loop-part and allowing a fermentation liquid present in the top tank to flow from the top tank into the loop-part; (ii) a first inlet connecting the top tank to the upflow part of the loop-part, allowing fermentation liquid present in the loop-part to flow from the loop part into the top tank; and (iii) a vent tube for discharging effluent gasses from the top tank; wherein the top tank further includes a visual inspection means.

Abstract: A system and a method is disclosed for adjusting and/or optimizing a fermentation process performed in one U-loop fermenter, the system including a processor and database for repetitively providing a test value of a fermenter parameter and for repetitively entering the test value of the parameter in the database wherein the database stores multiple test value entries at various points in time and also stores multiple control value entries at various points in time, wherein the processor performs a mathematical analysis of the test value for providing a calculated test value, and/or the control value for providing at least one calculated control value; and selects, on the basis of the calculated test value and/or on the calculated control value, an adjustment to be introduced into at least one other U-loop fermenter to benefit from the change made in the one U-loop fermenter.

Abstract: The present invention relates to a method for providing a fermentation medium for the cultivation of at least one methanotrophic organism, or for the cultivation of a combination of organisms comprising at least one methanotrophic organism, the method comprises the step of: (i) providing a main growth solution; (ii) optionally sterilizing the main growth solution provided in step (i); (iii) providing a trace metal solution; and (iv) mixing the main growth solution (as provided in step (i) or (ii)) with the trace metal solution provided in step (iii) and providing the fermentation medium for the cultivation of at least one methanotrophic organism, or for the cultivation of a combination of organisms comprising at least one methanotrophic organism.

Abstract: A fermentation reactor with a loop-part includes a circulation pump, a degassing-tank, and a fermentation liquid outlet for withdrawing fermentation liquid from the fermentation reactor, the degassing-tank including: (i) a first outlet connecting the degassing-tank to a first leg of the loop-part and allowing fermentation liquid present in the degassing-tank to flow into the loop-part; (ii) a first inlet connecting the degassing-tank to a second leg of the loop-part, allowing fermentation liquid present in the loop-part to flow into the degassing-tank; and (iii) a vent tube for discharging effluent gasses from the degassing tank, such as CO2; wherein one or more of the following criteria applies: (a) the loop-part is provided with an anti-vortex device; (b) certain volumetric ratios pertain between volumes relative to cross sections of reactor parts; (d) ratios pertain between different cross sectional areas of reactor parts.

Abstract: The present invention provides methods for assessing an ovarian cancer patient's survival status. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biological patterns in biological samples. The biological patterns are obtained using, for example, mass spectrometry systems and other techniques.

Abstract: The present invention describes a method for determining whether an individual is likely to have cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.

Abstract: An isolated pure culture of a strain of the yeast Phaffia rhodozyma which produces large amounts of astaxanthin, in excess of about 600 micrograms per gram of Phaffia rhodozyma dry matter, as determined by HPLC analysis, is disclosed.

Abstract: An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an amount of at least 600 .mu.g per g Phaffia rhodozyma dry matter, as determined by HPLC analysis.

Abstract: An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an amount of at least 600 .mu.g per g Phaffia rhodozyma dry matter, as determined by HPLC analysis.

Abstract: An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an mount of at least 600 .mu.g per g Phaffia rhodozyma dry matter, as determined by HPLC analysis.

Abstract: An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an amount of at least 600 .mu.g per g Phaffia rhodozyma dry matter, as determined by HPLC analysis.

Abstract: An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an amount of at least 600 .mu.g per g Phaffla rhodozyma dry matter, as determined by HPLC analysis.