Abstract: The present invention generally relates to the use of small particles, such as micro particles or nanoparticles, to produce a therapeutic scar such as “trans-mural” scarring or other desired “deep tissue” scarring. In one preferred embodiment, these particles can be delivered to a target location by an implant. More specifically, these particles can be incorporated into the structure of implants or into the coatings on implants. In another preferred embodiment, these small particles can be delivered directly with a catheter by electrophoresis or hydraulic pressure.

Abstract: The present invention generally relates to the use of small particles, such as micro particles or nanoparticles, to produce a therapeutic scar such as “trans-mural” scarring or other desired “deep tissue” scarring. In one preferred embodiment, these particles can be delivered to a target location by an implant. More specifically, these particles can be incorporated into the structure of implants or into the coatings on implants. In another preferred embodiment, these small particles can be delivered directly with a catheter by electrophoresis or hydraulic pressure.

Abstract: Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.

Abstract: Methods and devices are presented which act by cutting the renal nerves slowly through. The minimally invasive implantable devices can be delivered through state of the art delivery catheters into the renal arteries as known from stenting, and do not require external generators, thereby being easily to introduce in normal equipped radiology catheter labs.

Abstract: The present invention relates to a surgical catheter, and more particularly, a balloon catheter having an auxiliary lumen configured to permit the advancement of a functional measurement wire to a treatment site. The auxiliary lumen communicates with a working lumen that is configured to permit the advancement of a guidewire and the functional measurement wire, so that the guidewire and functional measurement wire may selectively be advanced to the treatment site during a surgical procedure.

Abstract: The present invention relates to a surgical catheter, and more particularly, a balloon catheter having an auxiliary lumen configured to permit the advancement of a functional measurement wire to a treatment site. The auxiliary lumen communicates with a working lumen that is configured to permit the advancement of a guidewire and the functional measurement wire, so that the guidewire and functional measurement wire may selectively be advanced to the treatment site during a surgical procedure.

Abstract: Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.

Abstract: Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.

Abstract: Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.

Abstract: Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.

Abstract: The present invention relates to a surgical catheter, and more particularly, a balloon catheter having an auxiliary lumen configured to permit the advancement of a functional measurement wire to a treatment site. The auxiliary lumen communicates with a working lumen that is configured to permit the advancement of a guidewire and the functional measurement wire, so that the guidewire and functional measurement wire may selectively be advanced to the treatment site during a surgical procedure.

Abstract: Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.

Abstract: The present disclosure relates to treatment of disorders in the heart rhythm regulation system and, more particularly, to a medical device for tissue cutting and/or migrating wherein the cutting and/or migrating is at least partly actuated by the swelling of a swellable material. The disclosure furthermore relates to a method of producing such a medical device, a kit of such medical devices, and a method for treating such disorders.

Abstract: The present invention relates to a surgical catheter, and more particularly, a balloon catheter having an auxiliary lumen configured to permit the advancement of a functional measurement wire to a treatment site. The auxiliary lumen communicates with a working lumen that is configured to permit the advancement of a guidewire and the functional measurement wire, so that the guidewire and functional measurement wire may selectively be advanced to the treatment site during a surgical procedure.

Abstract: The present invention relates to a surgical catheter, and more particularly, a balloon catheter having an auxiliary lumen configured to permit the advancement of a functional measurement wire to a treatment site. The auxiliary lumen communicates with a working lumen that is configured to permit the advancement of a guidewire and the functional measurement wire, so that the guidewire and functional measurement wire may selectively be advanced to the treatment site during a surgical procedure.

Abstract: Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.

Abstract: Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.

Abstract: Apparatus and methods for providing distal protection during a medical procedure that include a vascular filter having a self-expanding, porous foam body that conformably seals against a vessel wall and captures emboli within one or more recesses. The filter is coupled to a distal region of an elongated member, such as a guide wire. Delivery systems for use with filters of the present invention and methods of using the apparatus of the present invention also are provided.

Abstract: Apparatus and methods for providing distal protection during a medical procedure comprising a vascular filter having a self-expanding, porous foam body that conformably seals against a vessel wall and captures emboli within one or more recesses. The filter is coupled to a distal region of an elongated member, such as a guide wire. Delivery systems for use with filters of the present invention and methods of using the apparatus of the present invention also are provided.

Abstract: Apparatus for enhancing pushability and minimizing kinking of a balloon catheter is provided, wherein a catheter comprises inner and outer tubes, and a balloon that is proximally affixed to the outer tube and distally affixed to the inner tube. The outer tube extends distal to the proximal affixation point and at least partially into the balloon segment to provide additional stiffness and pushability. The outer tube may taper and connect to the inner tube or to radiopaque markers disposed thereon. The outer tube further may be selectively reinforced, as by using multipart construction or using different tube textures, to selectively provide added stiffness in areas susceptible to kinking.