Abstract: Methods and systems are disclosed for generating optimal data predictions in time series data signals based on empirically-optimized model selection, noise filtering, and window size selection using machine learning models. For example, the system may receive a first subset of time series data. The system may receive a prediction horizon. The system may generate a feature input based on the first subset of time series data and the prediction horizon. The system may input the feature input into a machine learning model, wherein the machine learning model includes multiple components. The system may receive an output from the machine learning model. The system may generate for display, on a user interface, a prediction for the first subset of time series data at the prediction horizon based on the output.