Abstract: The technology relates in part to compositions that include oligonucleotide probes useful for enriching nucleic acid preparation products for analysis, kits and related methods. Described herein are compositions comprising: a plurality of oligonucleotide probes capable of hybridizing to target nucleic acid fragments of cancer gene exons, introns, and untranslated regions surrounding cancer genes resulting from nucleic acid restriction enzyme cleavage of a nucleic acid sample, for use in capture-C technologies and methods associated therewith.