Patents by Inventor Ibrahim Khairoun
Ibrahim Khairoun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9913928Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.Type: GrantFiled: November 14, 2014Date of Patent: March 13, 2018Assignees: GRAFTYS, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)Inventors: Jean-Michel Bouler, Bruno Bujoli, Pascal Janvier, Ibrahim Khairoun, Jean-Noël Argenson
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Patent number: 9642939Abstract: The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.Type: GrantFiled: August 23, 2007Date of Patent: May 9, 2017Assignees: GRAFTYS, UNIVERSITE DE NANTESInventors: Ibrahim Khairoun, Pierre Weiss, Jean-Michel Bouler
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Publication number: 20150140118Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.Type: ApplicationFiled: November 14, 2014Publication date: May 21, 2015Inventors: Jean-Michel BOULER, Bruno BUJOLI, Pascal JANVIER, Ibrahim KHAIROUN, Jean-Noël ARGENSON
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Patent number: 8920555Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: GrantFiled: December 2, 2013Date of Patent: December 30, 2014Assignees: Graftys SA, University de Nantes, Centre National de la Recherche ScientifiqueInventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
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Patent number: 8894958Abstract: The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca+Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5% by weight. It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants. It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component. It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.Type: GrantFiled: March 3, 2010Date of Patent: November 25, 2014Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), University de Nantes, GraftysInventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler, Charlotte Mellier
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Patent number: 8889165Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.Type: GrantFiled: February 14, 2008Date of Patent: November 18, 2014Assignees: Graftys, Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Jean-Michel Bouler, Bruno Bujoli, Pascal Janvier, Ibrahim Khairoun, Jean-Noël Argenson
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Publication number: 20140087004Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5?1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: ApplicationFiled: December 2, 2013Publication date: March 27, 2014Inventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
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Patent number: 8623311Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: GrantFiled: March 3, 2010Date of Patent: January 7, 2014Assignees: Graftys, Universite de Nantes, Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
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Publication number: 20140004207Abstract: The present invention concerns a composition useful as bone substitute comprising one or more calcium-phosphate compounds in association with an analgesic. It also refers to a preparation process of said composition, a preparation process of a drug-combined device comprising said composition, the drug combined device thus obtained, a kit comprising said composition and the use of said composition for the preparation of a drug-combined device useful for filling a bony defect caused in the iliac crest by collection of auto-graft bone, as a scaffold for tissue engineering and to produce a dental or bony implant.Type: ApplicationFiled: September 3, 2013Publication date: January 2, 2014Applicants: Graftys, Ecole Nationale Veterinaire de Nantes, Universite de NantesInventors: Hervé Leguen, Rémi Cavagna, Ibrahim Khairoun, Elise Verron, Pascal Janvier, Olivier Gauthier, Jean-Michel Bouler
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Publication number: 20120111226Abstract: The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): Ca(005-1 5X)Gax(PO—O4)7, wherein 0<x<1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca+Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5% by weight. It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants. It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component. It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.Type: ApplicationFiled: March 3, 2010Publication date: May 10, 2012Applicants: GRAFTYS, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)Inventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler, Charlotte Mellier
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Publication number: 20120064170Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7, wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: ApplicationFiled: March 3, 2010Publication date: March 15, 2012Applicants: UNIVERSITE DE NANTES, GRAFTYSInventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
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Publication number: 20110142940Abstract: The present invention concerns a composition useful as bone substitute comprising one or more calcium-phosphate compounds in association with an analgesic. It also refers to a preparation process of said composition, a preparation process of a drug-combined device comprising said composition, the drug combined device thus obtained, a kit comprising said composition and the use of said composition for the preparation of a drug-combined device useful for filling a bony defect caused in the iliac crest by collection of auto-graft bone, as a scaffold for tissue engineering and to produce a dental or bony implant.Type: ApplicationFiled: January 6, 2009Publication date: June 16, 2011Applicants: GRAFTYS, UNIVERSITE DE NANTES, ECOLE NATIONALE VETERINAIRE DE NANTESInventors: Hervé Leguen, Rémi Cavagna, Ibrahim Khairoun, Elise Verron, Pascal Janvier, Olivier Gauthier, Jean-Michel Bouler
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Publication number: 20100269734Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: ApplicationFiled: March 3, 2010Publication date: October 28, 2010Inventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
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Publication number: 20100248191Abstract: The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): Ca(10.5?1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca+Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5% by weight. It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants. It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component. It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.Type: ApplicationFiled: March 3, 2010Publication date: September 30, 2010Inventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler, Charlotte Mellier
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Publication number: 20100197636Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.Type: ApplicationFiled: February 13, 2008Publication date: August 5, 2010Inventors: Jean-Michel Bouler, Bruno Bujoli, Pascal Janvier, Ibrahim Khairoun, Jean-Noël Argenson
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Publication number: 20100068243Abstract: The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.Type: ApplicationFiled: August 23, 2007Publication date: March 18, 2010Applicants: GRAFTYS, UNIVERSITE DE NANTESInventors: Ibrahim Khairoun, Pierre Weiss, Jean-Michel Bouler
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Publication number: 20080206296Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.Type: ApplicationFiled: February 14, 2008Publication date: August 28, 2008Inventors: Jean-Michel BOULER, Bruno Bujoli, Pascal Janvier, Ibrahim Khairoun, Jean-Noel Argenson
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Patent number: 7351280Abstract: A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.Type: GrantFiled: February 9, 2005Date of Patent: April 1, 2008Assignees: New York University, Institut National Dela Sante ET Dela Recherche Medicale, The University of NantesInventors: Ibrahim Khairoun, Racquel Z. LeGeros, Guy Daculsi, Jean-Michael Bouler, Jérôme Guicheux, Olivier Gauthier
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Publication number: 20050199156Abstract: A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.Type: ApplicationFiled: February 9, 2005Publication date: September 15, 2005Inventors: Ibrahim Khairoun, Racquel LeGeros, Guy Daculsi, Jean-Michael Bouler, Jerome Guicheux, Olivier Gauthier