Abstract: According to the teachings presented herein, each base station in a group of base stations is linked to an associated terminal as a receiver-transmitter pair. These receiver-transmitter pairs reuse channelization resources, such that each terminal represents a source of other-cell interference (also referred to as multi-user interference or MUI) for other terminals in neighboring cells that are reusing all or some of the same channelization resources. Accordingly, the base stations implement a gaming-based algorithm to mitigate MUI for the multiple-input-multiple-output (MIMO) uplink signals received from their associated terminals. More particularly, each base station functions as a player in a game, in which the allowed gaming action is the selection of the precoding matrix to be used for MIMO uplink transmissions to the base station from an associated terminal.