Abstract: A design assistance device (10) comprises: a determination rule definition unit (102) that defines a determination rule for determining whether a CAD model (103) violates a design guideline (101); a geometric shape recognition unit (105) that extracts, from the CAD model (103), a violation location violating the design guidelines (101), by using geometric shape recognition based on the determination rule defined by the determination rule definition unit (102); and a feature amount recognition unit (108) that identifies, from among violation locations, a violation location violating the design guidelines (101), by using feature amount recognition based on a prescribed feature amount of the violation location extracted by the geometric shape recognition unit (105).

Abstract: A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.

Abstract: An agent for treating Fabry disease, external analgesic, and perspiration enhancer in accordance with one embodiment of the present invention each contain rapamycin or a rapamycin derivative.

Abstract: A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.

Abstract: An external medicine for diffuse plexiform neurofibromas is provided. The external medicine for diffuse plexiform neurofibromas in accordance with an embodiment of the present invention contains, as an active ingredient, at least one selected from the group consisting of sirolimus and sirolimus derivatives.

Abstract: A pickup according to a present embodiment is used for a stringed instrument and converts a vibration of a string into an electric signal. The pickup includes a piezoelectric sensor that includes at least one piezoelectric element that is provided corresponding to the number of strings, a first electrode arranged on a string side of the piezoelectric element, and a second electrode arranged on an opposite side of the first electrode, a wiring electrically connected to the piezoelectric sensor, a protection part covering a portion where the piezoelectric sensor comes in contact with the string, and a cap that is formed integrally with the protection part, and comprises an arm part locked to the stringed instrument together with the string.

Abstract: A pickup according to a present embodiment is used for a stringed instrument and converts a vibration of a string into an electric signal. The pickup includes a piezoelectric sensor that includes at least one piezoelectric element that is provided corresponding to the number of strings, a first electrode arranged on a string side of the piezoelectric element, and a second electrode arranged on an opposite side of the first electrode, a wiring electrically connected to the piezoelectric sensor, a protection part covering a portion where the piezoelectric sensor comes in contact with the string, and a cap that is formed integrally with the protection part, and comprises an arm part locked to the stringed instrument together with the string.

Abstract: An external medicine for diffuse plexiform neurofibromas is provided. The external medicine for diffuse plexiform neurofibromas in accordance with an embodiment of the present invention contains, as an active ingredient, at least one selected from the group consisting of sirolimus and sirolimus derivatives.

Abstract: The present invention provides an antiperspirant which can effectively and safely control perspiration. The antiperspirant in accordance with an aspect of the present invention contains a mTOR inhibitor. The mTOR inhibitor can be rapamycin, a rapamycin derivative, or the like, and the antiperspirant can be used against hyperhidrosis and the like.

Abstract: An external medicine of the present invention includes a gel composition or an ointment composition, each of which contains sirolimus and/or a derivative thereof. Accordingly, provided is an external medicine which enables sirolimus, in an amount sufficient to treat a skin disease, to be absorbed into an affected part without causing a side effect.

Abstract: In a conventional wafer chamfering process, the chamfered shape (cross-sectional shape) of the wafer circumference is uniform. However, in the chamfering step in wafer manufacture, the uniform chamfered shape varies with respective circumferential positions. Therefore, a wafer chamfering method that takes into account deformation in the chamfering step in the wafer manufacture is to be provided. The wafer chamfering method is for chamfering a wafer by bringing a grooveless grindstone into contact with the edge (circumferential end) of a wafer. By this wafer chamfering method, a movement trajectory formed by moving the wafer and the grindstone in a relative manner in the Z-axis and Y-axis directions and forming the same cross-sectional shape on the entire wafer circumference is set as a reference.

Abstract: A truing method for a chamfering grindstone for performing chamfering work on a peripheral edge of a plate-shaped object, comprising the steps of: performing chamfering work on a truing grindstone with a master grindstone having a desired groove shape and forming a peripheral edge shape of the truing grindstone into a desired chamfered shape; and transferring the groove shape of the master grindstone onto the chamfering grindstone by performing grooving work on the chamfering grindstone with the chamfered truing grindstone to form the groove in the desired shape on the chamfering grindstone.

Abstract: The present invention provides the grinding wheel, the grinding apparatus and the grinding method of the present invention so that increase in the size of the grinding apparatus can be suppressed, and the back surface grinding of the wafer and the grinding of the peripheral edge part of the wafer are performed at the same time, whereby the peripheral edge part of the extremely thin wafer is prevented from being sharpened, and cracking and chipping of the wafer peripheral edge part can be prevented.

Abstract: A truing method for a chamfering grindstone for performing chamfering work on a peripheral edge of a plate-shaped object, comprising the steps of: performing chamfering work on a truing grindstone with a master grindstone having a desired groove shape and forming a peripheral edge shape of the truing grindstone into a desired chamfered shape; and transferring the groove shape of the master grindstone onto the chamfering grindstone by performing grooving work on the chamfering grindstone with the chamfered truing grindstone to form the groove in the desired shape on the chamfering grindstone.

Abstract: An apparatus for pointing twist drill bits includes a processing unit which has a rotary index plate on which are mounted a plurality, e.g., five, of drill bit holders which are circumferentially spaced apart at equal, e.g., 72-degree intervals, and a loading unit which has located adjacent to the index plate a rotary pedestal on which are mounted an equal number of transfer arms. Located around the periphery of the processing unit and loading unit are a plurality of processing stations and loading unit operation stations, respectively.

Abstract: A method of joining a sintered hard alloy member 1 such as a cylindrical rod-shaped twist drill bit blank made of material whose main component is tungsten carbide to a softer metal member such as a stainless steel shank 2 includes the steps of connecting the hard alloy member 1 and the metal member 2 to separate electrodes 3 and 4, applying a longitudinally directed force couple to the hard alloy member 1 and metal member 2 to press end faces of the members together to form an electrically conductive contact region, and passing a pulse of current through electrodes 3 and 4 of sufficient energy to melt the two end face regions of the members, thereby welding them together. Preferably, the end face of the metal member has a convex conical shape.

Abstract: An apparatus for pointing twist drill bits includes a processing unit which has a rotary index plate on which are mounted a plurality, e.g., five, of drill bit holders which are circumferentially spaced apart at equal, e.g., 72-degree intervals, and a loading unit which has located adjacent to the index plate a rotary pedestal on which are mounted an equal number of transfer arms. Located around the periphery of the processing unit and loading unit are a plurality of processing stations and loading unit operation stations, respectively.

Abstract: A grindstone and a wafer are rotated at high speeds in the same direction. The rotating wafer is slowly moved toward the rotating grindstone to thereby gradually chamfer the periphery of the wafer.

Abstract: A method of joining a sintered hard alloy member 1 such as a cylindrical rod-shaped twist drill bit blank made of material whose main component is tungsten carbide to a softer metal member such as a stainless steel shank 2 includes the steps of connecting the hard alloy member 1 and the metal member 2 to separate electrodes 3 and 4, applying a longitudinally directed force couple to the hard alloy member 1 and metal member 2 to press end faces of the members together to form an electrically conductive contact region, and passing a pulse of current through electrodes 3 and 4 of sufficient energy to melt the two end face regions of the members, thereby welding them together. Preferably, the end face of the metal member has a convex conical shape.

Abstract: A method and apparatus for automatically re-pointing twist drill bits includes a drill support mechanism including means for rotatably and axially translatably holding the shank of a drill bit, and a fluted portion receiver for supporting the fluted front cutting portion of the drill bit. The apparatus also includes an optical sensor unit which views the tip and blade part of the drill bit with the drill support mechanism in an off-line position, i.e., rotated away from a grinding wheel station. Responsive to error correction servo command signals received from a comparison of the actual orientation of drill bit cutting lips with a desired pre-determined template position, rotary and linear actuators in the drill support mechanism rotate the drill bit to the proper angular orientation, and advance the bit axially to a pre-determined protrusion length.