Patents by Inventor Ichiro Koguma
Ichiro Koguma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10400007Abstract: A method for purifying a biologically active substance from a solution mixture containing impurities and the biologically active substance, in which an ion exchange chromatography carrier comprising a matrix and a copolymer containing at least N-isopropylacrylamide as a monomer unit and immobilized to a surface of the matrix is used, and the solution mixture is allowed to flow through a container storing the carrier at a uniform temperature, thereby recovering the biologically active substance.Type: GrantFiled: April 15, 2014Date of Patent: September 3, 2019Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Hiroki Taniguchi, Masako Goto, Ichiro Koguma, Yoshiro Yokoyama
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Patent number: 10308678Abstract: The present invention provides a cation-exchange chromatographic support, comprising a membrane matrix and a copolymer immobilized on the surface of the membrane matrix, wherein the copolymer comprises a (meth)acrylamide-based compound and/or a (meth)acrylate-based compound as monomer units, and the support has one or more species of cation-exchange groups including at least a weak cation-exchange group at a density higher than 30 mmol/L per volume of the support.Type: GrantFiled: July 23, 2015Date of Patent: June 4, 2019Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Hiroki Taniguchi, Ichiro Koguma
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Publication number: 20170145050Abstract: The present invention provides a cation-exchange chromatographic support, comprising a membrane matrix and a copolymer immobilized on the surface of the membrane matrix, wherein the copolymer comprises a (meth)acrylamide-based compound and/or a (meth)acrylate-based compound as monomer units, and the support has one or more species of cation-exchange groups including at least a weak cation-exchange group at a density higher than 30 mmol/L per volume of the support.Type: ApplicationFiled: July 23, 2015Publication date: May 25, 2017Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Hiroki TANIGUCHI, Ichiro KOGUMA
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Patent number: 9643174Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.Type: GrantFiled: November 17, 2014Date of Patent: May 9, 2017Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Ichiro Koguma, Hiroki Shigematsu, Kazuo Okuyama, Teruo Okano, Yoshikatsu Akiyama, Kenichi Nagase
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Patent number: 9643173Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.Type: GrantFiled: December 19, 2011Date of Patent: May 9, 2017Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Ichiro Koguma, Hiroki Shigematsu, Kazuo Okuyama, Teruo Okano, Yoshikatsu Akiyama, Kenichi Nagase
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Publication number: 20160083419Abstract: A method for purifying a biologically active substance from a solution mixture containing impurities and the biologically active substance, in which an ion exchange chromatography carrier comprising a matrix and a copolymer containing at least N-isopropylacrylamide as a monomer unit and immobilized to a surface of the matrix is used, and the solution mixture is allowed to flow through a container storing the carrier at a uniform temperature, thereby recovering the biologically active substance.Type: ApplicationFiled: April 15, 2014Publication date: March 24, 2016Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Hiroki TANIGUCHI, Masako GOTO, Ichiro KOGUMA, Yoshiro YOKOYAMA
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Publication number: 20150239956Abstract: A method for manufacturing a high-affinity antibody including purifying an antibody to which a treatment of reducing the affinity for an antigen is not applied by a temperature responsive protein A medium, in which dissociation constant (KD value) to an antigen is smaller than the KD value of an antibody purified by an acid elution type protein A medium.Type: ApplicationFiled: June 27, 2013Publication date: August 27, 2015Applicants: ASAHI KASEI MEDICAL CO., LTD., NOMADIC BIOSCIENCE CO., LTD.Inventors: Ichiro Koguma, Kazuo Okuyama, Satoshi Sato
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Publication number: 20150218208Abstract: There is provided a method for purifying an antibody using temperature-responsive Protein A, wherein different buffer solutions are used in a washing step of washing a stationary phase having the temperature-responsive Protein A and in an elution step of eluting the antibody captured by the stationary phase, the method including the washing step of washing the stationary phase using a buffer solution at a temperature at which the temperature-responsive Protein A and the antibody are bound and having a first salt concentration, and the elution step of eluting the antibody captured by the stationary phase using a buffer solution at a temperature at which the antibody is released from the temperature-responsive Protein A and having a second salt concentration lower than the first salt concentration.Type: ApplicationFiled: August 27, 2013Publication date: August 6, 2015Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Ichiro Koguma, Rumiko Ishikawa, Hiroshi Takemasa, Kazuo Okuyama
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Publication number: 20150191506Abstract: It is an object of the present invention to provide an affinity chromatographic adsorbent using temperature-responsive protein A, wherein the adsorbent is capable of improving the culture productivity of the temperature-responsive protein A and the stability of the temperature-responsive protein A in cell disruption solution. According to the present invention, there is provided an adsorbent consisting of a carrier, to which a polypeptide comprising a tag peptide, a linker sequence, and a B-domain mutant derived from protein A from the N-terminal side thereof binds, wherein the linker sequence is an amino acid sequence that does not comprise a Val-Pro-Arg sequence and is composed of 7 to 12 amino acid residues; and the binding property of the B-domain mutant derived from protein A to an immunoglobulin can vary depending on temperature under conditions of pH 5 to 9 and a temperature of lower than 60° C.Type: ApplicationFiled: June 28, 2013Publication date: July 9, 2015Applicants: ASAHI KASEI MEDICAL CO., LTD., NOMADIC BIOSCIENCE CO., LTD.Inventors: Kazuo Okuyama, Ichiro Koguma, Tomokiyo Marumoto, Satoshi Sato
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Publication number: 20150080484Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.Type: ApplicationFiled: November 17, 2014Publication date: March 19, 2015Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Ichiro KOGUMA, Hiroki SHIGEMATSU, Kazuo OKUYAMA, Teruo OKANO, Yoshikatsu AKIYAMA, Kenichi NAGASE
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Publication number: 20130317172Abstract: A method for manufacturing a carrier having temperature responsive protein A, which is protein A mutated such that a binding property to an antibody changes depending upon temperature, immobilized thereto, wherein the temperature responsive protein A has the binding property to the antibody in a first temperature region and no binding property to the antibody in a second temperature region; and the method comprises a step of immobilizing the temperature responsive protein A to a carrier surface at a temperature within the first temperature region in which the temperature responsive protein A has the binding property to the antibody.Type: ApplicationFiled: December 26, 2011Publication date: November 28, 2013Applicants: NOMADIC BIOSCIENCE CO., LTD., ASAHI KASEI MEDICAL CO., LTD.Inventors: Ichiro Koguma, Hiroki Shigematsu, Kazuo Okuyama, Satoshi Sato
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Publication number: 20130317129Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.Type: ApplicationFiled: December 19, 2011Publication date: November 28, 2013Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Ichiro Koguma, Hiroki Shigematsu, Kazuo Okuyama, Teruo Okano, Yoshikatsu Akiyama, Kenichi Nagase
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Patent number: 7635513Abstract: A heat resistant microporous membrane containing a thermoplastic resin having a crystalline melting point of 140-300° C. and having a layer structure formed in the direction of membrane thickness, said layer structure containing 5-100% of a layer defined by the following (A) and 95-0% of a layer defined by the following (B): (A) a layer in which the micropores are intra-spherulitic voids, and (B) a layer in which the micropores are intra-spherulitic voids and inter-spherulitic voids.Type: GrantFiled: October 20, 2000Date of Patent: December 22, 2009Assignee: Asahi Kasei Medical Co., Ltd.Inventors: Izumi Hoshuyama, Fujiharu Nagoya, Ichiro Koguma
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Patent number: 7459085Abstract: A hydrophilic microporous membrane comprising a thermoplastic resin, having been subjected to hydrophilizing treatment and having a maximum pore size of 0 to 100 nm, wherein when 3 wt % bovine immunoglobulin having a monomer ratio of 80 wt % or more is filtered at a constant pressure of 0.3 MPa, an average permeation rate (liter/m2/h) for 5 minutes from the start of filtration (briefly referred to as globulin permeation rate A) satisfies the following formula (1) and an average permeation rate (liter/m2/h) for 5 minutes from the time point of 55 minutes after the start of filtration (briefly referred to as globulin permeation rate B) satisfies the following formula (2): Globulin permeation rate A>0.0015 ×maximum pore size (nm)2.75 ??(1) Globulin permeation rate B/globulin permeation rate A>0.2 .Type: GrantFiled: October 17, 2003Date of Patent: December 2, 2008Assignee: Asahi Kasei Medical Co., Ltd.Inventors: Ichiro Koguma, Fujiharu Nagoya
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Patent number: 7140496Abstract: A multilayer microporous membrane containing a thermoplastic resin, comprising a coarse structure layer with a higher open pore ratio and a fine structure layer with a lower open pore ratio, wherein said coarse structure layer is present at least in one membrane surface having a thickness of not less than 5.0 ?m, a thickness of said fine structure layer is not less than 50% of the whole membrane thickness, and said coarse structure layer and said fine structure layer are formed in one-piece.Type: GrantFiled: July 31, 2002Date of Patent: November 28, 2006Assignee: Asahi Kasei Medical Co., Ltd.Inventors: Fujiharu Nagoya, Ichiro Koguma
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Publication number: 20060016748Abstract: A hydrophilic microporous membrane comprising a thermoplastic resin, having been subjected to hydrophilizing treatment and having a maximum pore size of 10 to 100 nm, wherein when 3 wt % bovine immunoglobulin having a monomer ratio of 80 wt % or more is filtered at a constant pressure of 0.3 MPa, an average permeation rate (liter/m2/h) for 5 minutes from the start of filtration (briefly referred to as globulin permeation rate A) satisfies the following formula (1) and an average permeation rate (liter/m2/h) for 5 minutes from the time point of 55 minutes after the start of filtration (briefly referred to as globulin permeation rate B) satisfies the following formula (2): Globulin permeation rate A>0.0015×maximum pore size (nm)2.75 ??(1) Globulin permeation rate B/globulin permeation rate A>0.2 ??(2).Type: ApplicationFiled: October 17, 2003Publication date: January 26, 2006Inventors: Ichiro Koguma, Fujiharu Nagoya
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Publication number: 20040023017Abstract: A multilayer microporous membrane containing a thermoplastic resin, comprising a coarse structure layer with a higher open pore ratio and a fine structure layer with a lower open pore ratio, wherein said coarse structure layer is present at least in one membrane surface having a thickness of not less than 5.0 &mgr;m, a thickness of said fine structure layer is not less than 50% of the whole membrane thickness, and said coarse structure layer and said fine structure layer are formed in one-piece.Type: ApplicationFiled: January 31, 2003Publication date: February 5, 2004Inventors: Fujiharu Nagoya, Ichiro Koguma