Patents by Inventor Ichiro Shima
Ichiro Shima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20160176239Abstract: In a pneumatic tire, side wall rubbers have protruding portions which protrude toward outward sides in the tire width direction, a dimension in the tire diametrical direction of the protruding portion is equal to or less than a dimension in the tire diametrical direction of the cushion rubber, the protruding portions are arranged so as to overlap with the cushion rubbers in the tire width direction at least partly, and outer ends in the tire diametrical direction of the protruding portions are arranged at the same positions as outer ends in the tire diametrical direction of the cushion rubbers or closer to inner sides in the tire diametrical direction than the outer ends in the tire diametrical direction of the cushion rubbers.Type: ApplicationFiled: December 11, 2015Publication date: June 23, 2016Applicant: TOYO TIRE & RUBBER CO., LTD.Inventor: Ichiro Shima
-
Patent number: 9340074Abstract: A pneumatic tire has a bead filler, a carcass ply, a side wall rubber and a rim strip rubber. The rim strip rubber has a main portion arranged in an outer side in a tire width direction of the bead filler, and a thin portion arranged between the carcass ply and the side wall rubber. The main portion forms an outer surface of a bead portion. The thin portion extends in the tire diametrical direction at a substantially fixed thickness. An upper end of the thin portion is positioned in an outer side in the tire diametrical direction than an upper end of the bead filler and in an inner side in the tire diametrical direction than a roll-up end of the carcass ply.Type: GrantFiled: October 1, 2013Date of Patent: May 17, 2016Assignee: TOYO TIRE & RUBBER CO., LTD.Inventor: Ichiro Shima
-
Publication number: 20140090765Abstract: A pneumatic tire has a bead filler, a carcass ply, a side wall rubber and a rim strip rubber. The rim strip rubber has a main portion arranged in an outer side in a tire width direction of the bead filler, and a thin portion arranged between the carcass ply and the side wall rubber. The main portion forms an outer surface of a bead portion. The thin portion extends in the tire diametrical direction at a substantially fixed thickness. An upper end of the thin portion is positioned in an outer side in the tire diametrical direction than an upper end of the bead filler and in an inner side in the tire diametrical direction than a roll-up end of the carcass ply.Type: ApplicationFiled: October 1, 2013Publication date: April 3, 2014Applicant: TOYO TIRE & RUBBER CO., LTD.Inventor: Ichiro Shima
-
Patent number: 8245745Abstract: A pneumatic tire is provided with a main groove extending along a tire circumferential direction, and a land portion comparted by the main groove in a tread surface. A reinforcing member having a cord which is inclined at an angle between 75 and 90 degrees with respect to the tire circumferential direction is buried in the vicinity of a groove bottom height of the main groove in an inner region of the land portion.Type: GrantFiled: June 16, 2010Date of Patent: August 21, 2012Assignee: Toyo Tire & Rubber Co., Ltd.Inventor: Ichiro Shima
-
Publication number: 20110000594Abstract: A pneumatic tire is provided with a main groove extending along a tire circumferential direction, and a land portion comparted by the main groove in a tread surface. A reinforcing member having a cord which is inclined at an angle between 75 and 90 degrees with respect to the tire circumferential direction is buried in the vicinity of a groove bottom height of the main groove in an inner region of the land portion.Type: ApplicationFiled: June 16, 2010Publication date: January 6, 2011Applicant: Toyo Tire & Rubber Co., Ltd.Inventor: Ichiro Shima
-
Patent number: 7186731Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is ?CH2, ?CHF or ?CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.] having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.Type: GrantFiled: October 29, 2004Date of Patent: March 6, 2007Assignee: Astellas Pharma Inc.Inventors: Ichiro Shima, Akio Kuroda, Takehiko Ohkawa, Toshio Kurosaki, Yuki Sawada, Aiko Wada
-
Publication number: 20070006952Abstract: There is provided a pneumatic tire including cross grooves which are provided on a tread portion in such a manner as to cross each other in an X shape, as well as cross each other symmetrically with respect to a tire transverse line, wherein assuming that a point of intersection between a tire circumferential line which passes through a point of intersection A of the cross grooves and a tire contact patch shaping line is a point of intersection B, a crossing angle of the cross grooves which lie to hold therebetween a tire transverse line which passes through the point of intersection A is ??, and an angle made by a tire circumferential line which passes through the point of intersection B and a tangential line to the tire contact patch shaping line at the point of intersection B is ??, the cross grooves satisfy the following conditions: when ??<45°, ??<?2.5×??+162.5°??1) when 45°???<60°, ??>?1.2×??+179°??2) when 60°????90°, ??>105°.Type: ApplicationFiled: June 13, 2006Publication date: January 11, 2007Applicant: Toyo Tire & Rubber Co., Ltd.Inventors: Ichiro Shima, Van Doan
-
Patent number: 7129243Abstract: The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof.Type: GrantFiled: December 18, 2001Date of Patent: October 31, 2006Assignee: Astellas Pharma Inc.Inventors: Ichiro Shima, Takehiko Ohkawa, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
-
Publication number: 20050137224Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is ?CH2, ?CHF or ?CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.]having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.Type: ApplicationFiled: October 29, 2004Publication date: June 23, 2005Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.Inventors: Ichiro Shima, Akio Kuroda, Takehiko Ohkawa, Toshio Kurosaki, Yuki Sawada, Aiko Wada
-
Patent number: 6825200Abstract: The present invention a compound represented by the formula (I): where the structural variables R1-R6 are defined herein.Type: GrantFiled: May 6, 2002Date of Patent: November 30, 2004Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ichiro Shima, Takehiko Ohkawa, Kazuhiko Ohne, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
-
Publication number: 20040097425Abstract: The present invention relates to a compound of the formula (I)wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.Type: ApplicationFiled: December 23, 2003Publication date: May 20, 2004Inventors: Ichiro Shima, Takehiko Ohkawa, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
-
Publication number: 20020132809Abstract: 1Type: ApplicationFiled: February 25, 2002Publication date: September 19, 2002Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Teruo Oku, Ichiro Shima, Takehiko Ohkawa, Kazuhiko Ohne, Tatsuya Zenko, Kousei Yoshihara, Hiroyuki Setoi
-
Patent number: 6291464Abstract: This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity, etc., and represented by general formula [I]. wherein R1 is lower alkyl, etc., R2 is aryl, etc., A is or —SO2—, Q is —N═CH—, etc., X is lower alkylene, etc., and R3 and R4 are taken together to form lower alkylene, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof and a pharmaceutical composition comprising the same.Type: GrantFiled: August 17, 1999Date of Patent: September 18, 2001Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ichiro Shima, Kazuhiko Ohne
-
Patent number: 5430025Abstract: Trifluoromethylketone compounds of the formula: ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl which has one or two substituents selected from carboxy, esterified carboxy and di-C.sub.1-6 alkylcarbamoyl; phenyl(C.sub.1-6)alkyl, the phenyl moiety of which may have halogen or nitro or amino substituents and the alkyl moiety of which may have carboxy or esterified carboxy substituents; halo-phenyl; morpholino; or morpholino(C.sub.1-6)alkyl, R.sup.2 and R.sup.3 are each C.sub.1-6 alkyl, X is --or --NH--, and ##STR2## and pharmaceutically acceptable salts thereof are useful for inhibiting human elastase.Type: GrantFiled: November 30, 1993Date of Patent: July 4, 1995Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Ichiro Shima, Keisuke Imai, Hirokazu Tanaka
-
Patent number: 5296591Abstract: The trifluoromethylketone derivatives (I) and pharmaceutically acceptable salts thereof have a human leukocyte elastase inhibiting activity and are useful as human leukocyte elastase inhibitors for treating or preventing degenerative diseases. The trifluoromethylketone derivatives (I) have the following formula: ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl which has one or two substituents selected from carboxy, esterified carboxy and di-C.sub.1-6 alkylcarbamoyl; phenyl(C.sub.1-6) alkyl, the phenyl moiety of which may have halogen or nitro or amino substituents and the alkyl moiety of which may have carboxy or esterified carboxy substituents; halo-phenyl; morpholino; or morpholino(C.sub.1-6) alkyl,R.sup.2 and R.sup.3 are each C.sub.1-6 alkyl,X is -- or --NH--, andY is ##STR2## and pharmaceutically acceptable salts thereof.Type: GrantFiled: December 12, 1991Date of Patent: March 22, 1994Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Ichiro Shima, Keisuke Imai, Hirokazu Tanaka
-
Patent number: 5057513Abstract: The invention relates to thiazepine derivatives, which are antagonists of platelet activating factor, of the formula: ##STR1## wherein R.sup.1 is ar(lower)alkyl which may have suitable substituent(s),R.sup.2 is hydrogen, lower alkyl which may have suitable substituent(s), or a group of the formula: ##STR2## in which A is lower alkylene and X is halogen, n is 0, 1 or 2 and Y is --CH.sub.2 --CH.sub.2 -- or ##STR3## or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 4, 1990Date of Patent: October 15, 1991Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Ichiro Shima, Naoki Fukami, Masashi Hashimoto
-
Patent number: D766815Type: GrantFiled: June 22, 2015Date of Patent: September 20, 2016Assignee: Toyo Tire & Rubber Co., Ltd.Inventor: Ichiro Shima