Abstract: A method for producing a pharmaceutical dose form includes depositing a measured quantity of a first coating material on an external surface of the dose form in a patterned configuration. A measured quantity of a second coating material is deposited on the surface of the dose form in a patterned configuration in relationship to the first coating material. The first and second coating materials form a coating layer in overlying relationship with at least a portion of the external surface of the dose form.

Abstract: A method for producing an oral medication includes dispensing a structural material, the structural material including one of a polymer or a gelatin, curing the structural material, and dispensing a jettable pharmaceutical solution onto the cured structural material.

Abstract: The present invention provides pharmaceutical compositions. In one aspect, a pharmaceutical composition is provided having a plurality of polymeric film layers heat sealed together as a multilayer structure and having an active agent dispersed within the multilayer structure. The multilayer structure is configured to release the active agent upon administration to a subject, either in a controlled release or immediate release manner.

Abstract: The present invention is directed to a particulate pharmaceutical composition. The particulate pharmaceutical composition can comprise a water-soluble or partially water-soluble polymer matrix; and a plurality of nano-sized particles of active agent which are sparingly water-soluble to water-insoluble dispersed in the water-soluble or partially water-soluble polymer matrix. The particulate pharmaceutical composition can be micronized or in the form of a film that can be rolled up. If micronized, the individual micron-sized particles can have a plurality of nano-sized particles present in the micron-sized particles.

Abstract: A system for producing electrospray ions includes a thermal inkjet material dispenser configured to selectively emit a plurality of sample material particles, and an electrically conducting grid disposed in proximity with the thermal inkjet material dispenser, the grid being configured to permit a selective passage of the emitted sample material particles.

Abstract: A method of controlling a dissolution rate of a bioactive agent includes applying a first drop of solution carrying the bioactive agent at a first selected location on a delivery substrate, and positioning a second drop of solution carrying the bioactive agent at a second selected location on the delivery substrate, wherein the location of the first drop and the location of the second drop are selected based on a target dissolution rate.

Abstract: A method of controlling a dissolution rate of a bioactive agent includes selecting a desired dot topography corresponding to a target dissolution rate and applying a bioactive agent to a delivery substrate to form dots having the desired dot topography on the delivery substrate.

Abstract: A method of controlling a dissolution rate of a bioactive agent includes selecting a desired dot size corresponding to a target dissolution rate, and applying a bioactive agent to a delivery substrate in drops of solution configured to form dots having the desired dot size on the delivery substrate.