Patents by Inventor Idit Shachar

Idit Shachar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210052626
    Abstract: A method of treating a malignant disease involving T cell exhaustion in a subject, with the proviso that said malignant disease is not a B cell malignancy, is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84, thereby treating the malignant disease involving the T cell exhaustion. Also disclosed is a method of treating an autoimmune or inflammatory disease in a subject, the method comprising administering to a subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84. A method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of SLAMF1, with the proviso that said agent is not an agent capable of decreasing an activity or expression of CD84, is also disclosed.
    Type: Application
    Filed: November 5, 2020
    Publication date: February 25, 2021
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Idit SHACHAR, Hadas LEWINSKY, Lihi RADOMIR, Anna WIENER
  • Patent number: 10828318
    Abstract: A method of treating a malignant disease involving T cell exhaustion in a subject, with the proviso that said malignant disease is not a B cell malignancy, is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84, thereby treating the malignant disease involving the T cell exhaustion. Also disclosed is a method of treating an autoimmune or inflammatory disease in a subject, the method comprising administering to a subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84. A method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of SLAMF1, with the proviso that said agent is not an agent capable of decreasing an activity or expression of CD84, is also disclosed.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: November 10, 2020
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Idit Shachar, Hadas Lewinsky, Lihi Radomir, Anna Wiener
  • Publication number: 20200263135
    Abstract: A method of generating hematopoietic stem cells for transplantation is disclosed. The method comprising: (a) collecting hematopoietic stem cells; and (b) contacting the hematopoietic stem cells with an agent capable of decreasing an activity or expression of CD74 and/or of macrophage migration inhibitory factor (MIF), to thereby generate hematopoietic stem cells for transplantation, and wherein the hematopoietic stem cells are not transduced with a lentivirus. Methods of increasing mobilization of hematopoietic stem cells and methods of treatment are also provided.
    Type: Application
    Filed: November 14, 2018
    Publication date: August 20, 2020
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Idit SHACHAR, Shirly HERMAN
  • Patent number: 10611839
    Abstract: An isolated antibody comprising an antigen recognition domain which specifically binds CD84 and (i) down regulates the anti-apoptotic activity of stromal cells on chronic lymphocytic leukemia (CLL) cells; and/or (ii) induces mobilization of CLL cells from the bone marrow. Also provided are antibodies comprising antigen recognition domains comprising complementarity determining regions as indicated and uses thereof.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: April 7, 2020
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Idit Shachar, Inbal Binsky, Ayelet Marom
  • Publication number: 20190359708
    Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
    Type: Application
    Filed: June 4, 2019
    Publication date: November 28, 2019
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Idit SHACHAR, Inbal BINSKY, Mirko SOBOTTA
  • Patent number: 10329347
    Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: June 25, 2019
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Idit Shachar, Inbal Binsky, Mirko Sobotta
  • Publication number: 20190015441
    Abstract: A method of treating a malignant disease involving T cell exhaustion in a subject, with the proviso that said malignant disease is not a B cell malignancy, is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84, thereby treating the malignant disease involving the T cell exhaustion. Also disclosed is a method of treating an autoimmune or inflammatory disease in a subject, the method comprising administering to a subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84. A method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of SLAMF1, with the proviso that said agent is not an agent capable of decreasing an activity or expression of CD84, is also disclosed.
    Type: Application
    Filed: January 5, 2017
    Publication date: January 17, 2019
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Idit SHACHAR, Hadas LEWINSKY, Lihi RADOMIR, Anna WIENER
  • Publication number: 20180327493
    Abstract: An isolated antibody comprising an antigen recognition domain which specifically binds CD84 and (i) down regulates the anti-apoptotic activity of stromal cells on chronic lymphocytic leukemia (CLL) cells; and/or (ii) induces mobilization of CLL cells from the bone marrow. Also provided are antibodies comprising antigen recognition domains comprising complementarity determining regions as indicated and uses thereof.
    Type: Application
    Filed: July 30, 2018
    Publication date: November 15, 2018
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Idit SHACHAR, Inbal BINSKY, Ayelet MAROM
  • Patent number: 10066014
    Abstract: An isolated antibody comprising an antigen recognition domain which specifically binds CD84 and (i) down regulates the anti-apoptotic activity of stromal cells on chronic lymphocytic leukemia (CLL) cells; and/or (ii) induces mobilization of CLL cells from the bone marrow. Also provided are antibodies comprising antigen recognition domains comprising complementarity determining regions as indicated and uses thereof.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: September 4, 2018
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Idit Shachar, Inbal Binsky, Ayelet Marom
  • Publication number: 20170260270
    Abstract: An isolated antibody comprising an antigen recognition domain which specifically binds CD84 and (i) down regulates the anti-apoptotic activity of stromal cells on chronic lymphocytic leukemia (CLL) cells; and/or (ii) induces mobilization of CLL cells from the bone marrow. Also provided are antibodies comprising antigen recognition domains comprising complementarity determining regions as indicated and uses thereof.
    Type: Application
    Filed: February 5, 2015
    Publication date: September 14, 2017
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Idit SHACHAR, Inbal BINSKY, Ayelet MAROM
  • Publication number: 20150344972
    Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
    Type: Application
    Filed: August 17, 2015
    Publication date: December 3, 2015
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Idit SHACHAR, Inbal BINSKY, Mirko SOBOTTA
  • Patent number: 9109029
    Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: August 18, 2015
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Idit Shachar, Inbal Binsky, Mirko Sobotta
  • Publication number: 20140147451
    Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
    Type: Application
    Filed: February 5, 2014
    Publication date: May 29, 2014
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Idit SHACHAR, Inbal Binsky, Mirko Sobotta
  • Patent number: 8686121
    Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: April 1, 2014
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Idit Shachar, Inbal Binsky, Mirko Sobotta
  • Publication number: 20120070449
    Abstract: A method of treating an inflammation in a subject in need thereof is disclosed. The method comprising administering to the subject an agent capable of down-regulating an activity or expression of CD151 in a lymphocyte, with the proviso that the agent is not CCL2, thereby treating the inflammation.
    Type: Application
    Filed: May 27, 2010
    Publication date: March 22, 2012
    Applicant: Yeda Research And Development Co. Ltd.
    Inventors: Idit Shachar, Einat Toister
  • Publication number: 20110189202
    Abstract: A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
    Type: Application
    Filed: September 23, 2009
    Publication date: August 4, 2011
    Applicant: Yeda Research And Development Co., Ltd.
    Inventors: Idit Shachar, Inbal Binsky, Mirko Sobotta
  • Publication number: 20110165116
    Abstract: A method of treating an inflammation in a subject thereof is provided. The method comprising administering to the subject a therapeutically effective amount of CCL2, thereby treating the inflammation. Also provided are pharmaceutical compositions and unit dosage forms which comprise CCL2 for the treatment of inflammation.
    Type: Application
    Filed: March 17, 2011
    Publication date: July 7, 2011
    Applicant: Yeda Research And Development Co., Ltd.
    Inventors: Liat FLAISHON, Idit Shachar
  • Patent number: 7919077
    Abstract: A method of treating an inflammation in a subject thereof is provided. The method comprising administering to the subject a therapeutically effective amount of CCL2, thereby treating the inflammation. Also provided are pharmaceutical compositions and unit dosage forms which comprise CCL2 for the treatment of inflammation.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: April 5, 2011
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Liat Flaishon, Idit Shachar
  • Publication number: 20090239799
    Abstract: A method of treating an inflammation in a subject thereof is provided. The method comprising administering to the subject a therapeutically effective amount of CCL2, thereby treating the inflammation. Also provided are pharmaceutical compositions and unit dosage forms which comprise CCL2 for the treatment of inflammation.
    Type: Application
    Filed: June 28, 2007
    Publication date: September 24, 2009
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Liat Flaishon, Idit Shachar
  • Publication number: 20080145337
    Abstract: A method of treating an inflammation in a subject in need thereof is disclosed. The method comprises locally or systemically administering to the subject IFN-gamma in an amount so as to achieve an IFN-gamma bulk tissue concentration at a site of inflammation of 1-8,000 units per kilogram body weight, thereby ameliorating the inflammation.
    Type: Application
    Filed: February 19, 2008
    Publication date: June 19, 2008
    Applicant: Yeda Research And Development Co. Ltd.
    Inventors: Idit Shachar, Liat Flaishon