Patents by Inventor Ido YOFE

Ido YOFE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISP-seq, an integrated method for massively parallel single cell RNA-seq and CRISPR pooled screens
    Patent number: 11485971
    Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 1, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ido Amit, Diego Jaitin, David Lara-Astiaso, Assaf Weiner, Ido Yofe
  • METHOD FOR STABILIZING INTRACELLULAR RNA
    Publication number: 20220307008
    Abstract: A method of permeabilizing a cell is disclosed. Kits for permeabilizing cells and analysing RNA contents are also disclosed.
    Type: Application
    Filed: June 16, 2020
    Publication date: September 29, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Ido YOFE, Diego JAITIN, Yonatan KATZENELENBOGEN, Mami LENNIKOV, Assaf WEINER, Hadas KEREN-SHAUL
  • METHODS OF ACTIVATING DYSFUNCTIONAL IMMUNE CELLS AND TREATMENT OF CANCER
    Publication number: 20210293820
    Abstract: Method of activating dysfunctional T cells, determining responsiveness of a subject having a tumor to an immune checkpoint inhibition are provided. Also provided is an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor. Additionally or alternatively provided is an immune checkpoint inhibitor and an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor.
    Type: Application
    Filed: May 31, 2021
    Publication date: September 23, 2021
    Applicants: Yeda Research and Development Co. Ltd., Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis
    Inventors: Ido AMIT, Hanjie LI, Amos TANAY, Ido YOFE, Yaniv EYAL-LUBLING, Antonius Nicolaas Maria SCHUMACHER, Anne Magdalena VAN DER LEUN
  • CRISP-SEQ, AN INTEGRATED METHOD FOR MASSIVELY PARALLEL SINGLE CELL RNA-SEQ AND CRISPR POOLED SCREENS
    Publication number: 20190194653
    Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.
    Type: Application
    Filed: September 14, 2017
    Publication date: June 27, 2019
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Diego JAITIN, David LARA-ASTIASO, Assaf WEINER, Ido YOFE