Abstract: Systems and methods for medical diagnosis are described by the present disclosure. In some embodiments, the systems include an input device operable for a patient to enter primary symptoms being experienced, a processing device operable for processing the primary symptoms to form a provisional diagnosis, and an output device operable for providing the provisional diagnosis to the patient. In other embodiments, the systems include an input device operable for a patient to enter medical history and primary symptoms being experienced, a processing device operable for interactively querying the patient based on the medical history and the primary symptoms to determine if additional symptoms are being experienced, a communication device operable for communicating with a physician's office and an output device operable for providing medical advice to the patient. The medical advice is given by the physician's office when the physician's office is open and by the system when the physician's office is closed.