Abstract: Apparatus and methods are described including driving a coil to apply a magnetic stimulation to a subject's brain, and receiving a magnetic-stimulation-evoked-potential signal from electrodes that are placed in contact with the subject's head. A slope of a late portion of a curve of the magnetic-stimulation-evoked-potential signal is measured. At least partially in response to detecting an indication that the slope of the late portion of the curve of the magnetic-stimulation-evoked-potential signal is below a given threshold, an output is generated that is indicative of the subject being at risk of dementia. Other applications are also described.

Abstract: The present invention provides an electrode headset grid adapted to fit on a head of a human subject, the grid comprising a plurality of conductive regions, electrically isolated from each other, wherein the conductive regions are configured to contact at least one electrode, and wherein the configuration of the conductive regions is configured to define an operating electrode unit. There is further provided an integrated system for brain electric stimulation and EEG monitoring, the system comprising the electrode headset grid and a plurality of electrodes. The invention further provides use of the electrode headset grid in an integrated non-invasive brain electrical stimulation and monitoring procedure.

Abstract: Systems and a computer implemented method for classifying a brain status of a subject, from a neural activity response of the subject to an induced TMS stimulation; the method comprising: constructing a machine learning classifier (MLC) configured to classify a subjects brain status; training the MLC using a training set, the training set comprising pairs of training output-classification vectors and their corresponding training input vectors, all extracted from a database of subjects with known brain status classifications; and applying the trained MLC on an input vector comprising features extracted from a tested-subjects brain neural activity response to the induced TMS stimulation, to obtain an output classification vector for the tested-subjects brain status.

Abstract: Methods, systems and devices for detecting and treating cognitive impairment conditions by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the cognitive impairment condition.

Abstract: Methods, systems and devices for detecting and treating cognitive impairment conditions by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the cognitive impairment condition.

Abstract: Methods, systems and devices for treating chronic pain by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity and/or excitability of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the chronic pain.

Abstract: The present disclosure provides methods, systems and devices for assessing brain neural activity and/or characteristics by providing at least two TMS stimulation pulses, obtaining an EEG indicative of brain activity responses associated with the at least two TMS stimulation pulses and compare the brain activity responses to evaluate neural characteristic of the brain.

Abstract: The present invention provides an electrode headset grid adapted to fit on a head of a human subject, the grid comprising a plurality of conductive regions, electrically isolated from each other, wherein the conductive regions are configured to contact at least one electrode, and wherein the configuration of the conductive regions is configured to define an operating electrode unit. There is further provided an integrated system for brain electric stimulation and EEG monitoring, the system comprising the electrode headset grid and a plurality of electrodes.

Abstract: A method of treating Alzheimer's disease (AD) is disclosed. The method comprises electrically stimulating a nerve pathway in a brain region of a subject with at least two high frequency spike bursts of electrical currents, the bursts comprising between 2-20 spikes, wherein a frequency of the spikes in the bursts is between 5-200 msec.