Abstract: This invention relates to a system and method of detecting any compromise to the seal separating the compartments in two-compartment flexible packages. Such seal tamper indicating system may include a middle seal area configured to form an interface compartment between the two main compartments, the interface compartment providing a visual indicator of whether a seal has been compromised. In another embodiment, a flow valve device may be connected between two compartments, the normally closed position of the valve providing the sealing between the two compartments until the contents of the two compartments are ready to be mixed.

Abstract: An apparatus and method for providing a controlled temperature environment for an extended period of time. The apparatus comprises a thermal chamber for holding a heat exchange substance, the heat exchange substance having a reservoir temperature, and one or more storage chambers for holding a storage specimen, wherein the storage chambers are in thermal communication with the thermal chamber through one or more insulation element, such that when the thermal chamber is holding a heat exchange substance, each of the storage chambers maintain a range of predetermined storage temperature that is between the reservoir temperature and the ambient temperature.

Abstract: A process and apparatus for preparing a multi-compartment container having two open ends and a partition wall that forms a fluid-tight seal defining two compartments each holding a separate component to be mixed with one another by the end-user prior to use. The process and apparatus for filling the two-compartment container comprises filling one compartment with material through an opening at one end of the container; sealing the opening; rotating the container; filling the other compartment with material through an opening at the other end of the container; and sealing the other opening preferably with a removable seal.

Abstract: A container holding two separate components which are mixed prior to use is provided. The container comprises a housing with a dispensing opening and neck portion between said opening and the bottom end of housing. The container further comprises a displaceable member disposed within the housing and having a partition wall with an edge adapted for a sealing engagement with internal walls of the neck portion, thereby defining two compartments separated by said partition wall. A displaceable member is axially displaceable between two positions along an axis extending through the neck portion. These two positions comprise a first position where the edge of the partition wall sealingly engages the internal walls of the neck portion, and a second position where the edge of the partition wall and the internal walls are disengaged permitting flow communication between the two compartments. This flow communication allows mixing of the two components to form a formulation which is then ready for use.

Abstract: A container holding two separate components, which are mixed prior to use is provided. The container comprises a housing defining a first compartment having a sealable opening and a neck portion between said first compartment and said opening. The container further comprises a displaceable member which is disposed within the housing which has a partition wall with an edge adapted for sealing engagement with the internal wall of the neck portion, thereby defining a second compartment sealed from the first compartment and being in flow communication with the opening. The displaceable member is axially displaceable between two positions along an axis extending through the neck portion. These two positions comprise a first position where the edge of the partition wall sealably engages the internal walls of the neck portion, and a second position where the edge of the partition wall and the internal walls of the neck portion are disengaged, permitting flow communication between the two compartments.