Patents by Inventor Ignacio Casal

Ignacio Casal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant VP2 parvoviral pseudo-particles encoding CTL or T-helper cell epitopes
    Patent number: 6458362
    Abstract: Attempts to generate modified viral pseudo-particles that are capable of stably incorporating heterologous antigenic determinants has encountered a number of difficulties including inhibition of pseudo-particle formation following epitope insertion and failure of the epitope to retain its native configuration. The present invention is directed toward recombinant viral pseudo-particles of the family Parvoviridae that stably encode heterologous epitopes. Hybrid virus-like particles (VLP) were prepared by self-assembly of a modified porcine parvovirus (PPV) VP2 capsid protein carrying a CD8+ or CD4+ T cell epitope in the amino terminus. Immunization of mice with hybrid pseudo-particles carrying a lymphocytic choriomeningitis virus (LCMV) nucleoprotein CTL epitope, without adjuvant, induced strong cytotoxic T lymphocyte (CTL) responses against both peptide-coated- or virus-infected-target cells.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: October 1, 2002
    Assignees: Institut Pasteur, Immunologia Y Genetica Aplicada S.A.
    Inventors: Ignacio Casal, Christine Sedlik, Javier Sarraseca, Richard Lo-Man, Paloma Rueda, Claude Leclerc