Patents by Inventor Ignacio HERRAIZ SIERRA

Ignacio HERRAIZ SIERRA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of deoxycholic acid, and intermediates useful in the preparation of deoxycholic acid
    Patent number: 11117925
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to novel intermediates useful for the preparation of DCA and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: September 14, 2021
    Assignee: BIONICE, S.L.U.
    Inventors: Antonio Lorente Bonde-Larsen, Ignacio Herraiz Sierra, Yolanda Fernandez Sainz, Jose Luis Barredo Fuente, Alfonso Perez Encabo, Jose Angel Turiel Hernandez
  • INTERMEDIATES FOR THE PREPARATION OF 11-METHYLENE STEROIDS
    Publication number: 20210269474
    Abstract: Compounds having the formula or solvates of the compounds can be used as intermediates in the preparation of the synthetic steroids, Etonogestrel and Desogestrel, as well as other pharmaceutically active agents.
    Type: Application
    Filed: May 13, 2021
    Publication date: September 2, 2021
    Inventors: Celso Miguel SANDOVAL RODRÍGUEZ, Ignacio HERRÁIZ SIERRA, lvano MESSINA, Jesús Miguel IGLESIAS RETUERTO
  • Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
    Patent number: 11104702
    Abstract: A process for the preparation of obeticholic acid and derivatives thereof by: (a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereof to obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereof and (b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: August 31, 2021
    Assignee: CRYSTAL PHARMA, S.A.U.
    Inventors: Ignacio Herráiz Sierra, Yolanda Fernández Sainz, Carlos Cordovilla Losada, Alfonso Pérez Encabo, José Angel Turiel Hernandez
  • Process and new intermediates for the preparation of 11-methylene steroids
    Patent number: 11034716
    Abstract: A process for the preparation of 11-methylene steroids from di-keto steroids involves selective olefination of the ketone at position 11 of the di-keto steroids. The resulting 11-methylene steroid products can be used as intermediates in the preparation of the synthetic steroids, Etonogestrel and Desogestrel, as well as other pharmaceutically active agents.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: June 15, 2021
    Assignee: CRYSTAL PHARMA, S.A.U.
    Inventors: Celso Miguel Sandoval Rodríguez, Ignacio Herráiz Sierra, Ivano Messina, Jesús Miguel Iglesias Retuerto
  • PREPARATION OF DEOXYCHOLIC ACID
    Publication number: 20200262863
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to DCA and pharmaceutically acceptable salts thereof, the carbon atoms of which are derived partially or solely from plant sources.
    Type: Application
    Filed: October 24, 2018
    Publication date: August 20, 2020
    Inventors: Ignacio Herraiz Sierra, Alfonso Pérez Encabo, Antonio Lorente Bonde-Larsen, Francisco Javier Guerra Navarro, Yolanda Fernandez Sainz, José Luis Barredo Fuente, José Angel Turiel Hernandez
  • PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF OBETICHOLIC ACID AND DERIVATIVES THEREOF
    Publication number: 20200165289
    Abstract: A process for the preparation of obeticholic acid and derivatives thereof by: (a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereof to obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereof and (b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof
    Type: Application
    Filed: June 22, 2018
    Publication date: May 28, 2020
    Inventors: Ignacio HERRÁIZ SIERRA, Yolanda FERNANDEZ SAINZ, Carlos CORDOVILLA LOSADA, Alfonso PÉREZ ENCABO, José Angel TURIEL HERNANDEZ
  • PROCESS AND NEW INTERMEDIATES FOR THE PREPARATION OF 11-METHYLENE STEROIDS
    Publication number: 20190092807
    Abstract: The invention relates to a process for the preparation of 11-methylene steroids through selective olefination of the ketone at position 11. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as Etonogestrel and Desogestrel.
    Type: Application
    Filed: March 2, 2017
    Publication date: March 28, 2019
    Inventors: Celso Miguel SANDOVAL RODRÍGUEZ, Ignacio HERRÁIZ SIERRA, lvano MESSINA, Jesús Miguel IGLESIAS RETUERTO
  • METHODS FOR THE PREPARATION OF DEOXYCHOLIC ACID, AND INTERMEDIATES USEFUL IN THE PREPARATION OF DEOXYCHOLIC ACID
    Publication number: 20180305395
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to novel intermediates useful for the preparation of DCA and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 6, 2017
    Publication date: October 25, 2018
    Inventors: Antonio LORENTE BONDE-LARSEN, Ignacio HERRAIZ SIERRA, Yolanda FERNANDEZ SAINZ, Jose Luis BARREDO FUENTE, Alfonso PEREZ ENCABO, Jose Angel TURIEL HERNANDEZ
  • PREPARATION OF DEOXYCHOLIC ACID
    Publication number: 20180086786
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to DCA and pharmaceutically acceptable salts thereof, the carbon atoms of which are derived solely from plant sources.
    Type: Application
    Filed: December 4, 2017
    Publication date: March 29, 2018
    Inventors: Antonio LORENTE BONDE-LARSEN, Ignacio HERRAIZ SIERRA, Yolanda FERNANDEZ SAINZ, Jose Luis BARREDO FUENTE, Alfonso PEREZ ENCABO, Jose Angel TURIEL HERNANDEZ, Francisco Javier GUERRA NAVARRO