Abstract: FoxO inhibitors for use in the treatment of diseases caused by abnormal TDP-43 and/or FUS proteins. The present invention refers to FoxO inhibitors, preferably quinolone derivatives, for use in the treatment of diseases caused by alterations of TDP-43 and/or FUS proteins, preferably Amyotrophic lateral sclerosis (ALS).

Abstract: When a multimedia conference between multiple users at multiple locations is established, a first cursor controlled by a first user in a first location is provided. A first event associated with the multimedia conference is detected. In response to detecting the first event associated with the multimedia conference, control of cursors in the multimedia conference can be handled in various ways to enhance the multimedia conference. For example, control of the first cursor can be switched from the first user to a second user at a second location, a second cursor can be provided to the multimedia conference that is controlled by the second user, or control of the first cursor can be merged so that the first cursor can be controlled by both the first user and the second user. This allows for enhanced control of the cursor in the multimedia conference that more closely resembles an in-person conference.

Abstract: The present invention relates to 1,2,3-triazoles of formula: useful for improving or restoring the intracellular calcium homeostasis and RyR-calstabin binding function in human and animal cells. The present invention also relates to methods for synthesizing said compounds, to pharmaceutical compositions containing them, and to the use thereof for preventing or treating skeletal muscle, heart and nervous system disorders.

Abstract: The present invention relates to 1,2,3-triazoles of formula: useful for improving or restoring the intracellular calcium homeostasis and RyR-calstabin binding function in human and animal cells. The present invention also relates to methods for synthesizing said compounds, to pharmaceutical compositions containing them, and to the use thereof for preventing or treating skeletal muscle, heart and nervous system disorders.

Abstract: When a multimedia conference between multiple users at multiple locations is established, a first cursor controlled by a first user in a first location is provided. A first event associated with the multimedia conference is detected. In response to detecting the first event associated with the multimedia conference, control of cursors in the multimedia conference can be handled in various ways to enhance the multimedia conference. For example, control of the first cursor can be switched from the first user to a second user at a second location, a second cursor can be provided to the multimedia conference that is controlled by the second user, or control of the first cursor can be merged so that the first cursor can be controlled by both the first user and the second user. This allows for enhanced control of the cursor in the multimedia conference that more closely resembles an in-person conference.

Abstract: Equivalence classes are used to determine how groups of call participants are distributed among remotely situated conference rooms. A roster of conference call participants is distributed for display by communication devices the participants bring to a conference room. The distributed roster contains at least one indicium by which the possession of an attribute, by any conference call participant in a room can be confirmed by other conference call participant(s) using a communication device. After entering a room, at least some participants use a communication device to access the roster and indicate, to a server, that at least one other participant on the roster possesses an attribute of significance to conduct of the call. Participants are assigned to groups and the groups are merged based on the presence of participants possessing an attribute or set of linked attributes. The server assigns the participants to respective groups for selective treatment.

Abstract: The system and method determine an activity associated with a user. An action associated with a media type of the activity or a role of the user within the activity is determined. For example, the activity can be how much the user talks during a conference call or if the user's role is that of a moderator. In response to determining the action associated with the media type of the activity or the role of the user within the activity, a presence state of the user is modified. The modified presence state is then communicated to a second user. This allows for a more accurate presence state of the user. It also allows other users to make contact at times where the user is more likely to communicate.

Abstract: Disclosed is a system and method integrating two different conferencing systems through an automatic mapping mechanism. Conference across two different systems are automatically connected without users in both systems being required to be provisioned.

Abstract: The system and method determine an activity associated with a user. An action associated with a media type of the activity or a role of the user within the activity is determined. For example, the activity can be how much the user talks during a conference call or if the user's role is that of a moderator. In response to determining the action associated with the media type of the activity or the role of the user within the activity, a presence state of the user is modified. The modified presence state is then communicated to a second user. This allows for a more accurate presence state of the user. It also allows other users to make contact at times where the user is more likely to communicate.

Abstract: Cyclotetrapeptides of formula (I) or their pharmaceutically acceptable salts, cyclo[Arg-Asp-(beta-Lactam)] (I) wherein (beta-Lactam) is a biradical of the formula (II) wherein the terminal NH group of the (beta-Lactam) is attached to the ?-carbonyl group of the aspartic residue (Asp), and the terminal carbonyl group of the (beta-Lactam) is attached to the ?-amino group the arginine residue (Arg); processes for their preparation, and pharmaceutical compositions containing them, as well as their use in human and animal therapy.

Abstract: Techniques are disclosed for conference expansion in a conferencing system. For example, a method of providing for conference expansion in a conferencing system includes the following steps. At least one port is reserved in an original conference allocated in the conferencing system. A hub conference is allocated, when a maximum number of participants for the original conference is reached. A calculated number of ports in the hub conference are reserved for linking to the original conference and to a corresponding number of expansion conferences when allocation of at least one of the number of expansion conferences is called for. The hub conference is linked to the original conference via the reserved port of the original conference and one of the reserved ports of the hub conference.

Abstract: A method, apparatus and computer program product for providing communications including an extended protocol header is presented. A message is provided in a communication protocol, the message having a header. An extension is included in the header, the extension including additional information. The message is transmitted to a recipient, wherein the recipient is capable of utilizing the additional information contained in the extension to the header to provide additional functionality.

Abstract: A method, apparatus and computer program product for providing communications including an extended protocol header is presented. A message is provided in a communication protocol, the message having a header. An extension is included in the header, the extension including additional information. The message is transmitted to a recipient, wherein the recipient is capable of utilizing the additional information contained in the extension to the header to provide additional functionality.

Abstract: Techniques are disclosed for conference expansion in a conferencing system. For example, a method of providing for conference expansion in a conferencing system includes the following steps. At least one port is reserved in an original conference allocated in the conferencing system. A hub conference is allocated, when a maximum number of participants for the original conference is reached. A calculated number of ports in the hub conference are reserved for linking to the original conference and to a corresponding number of expansion conferences when allocation of at least one of the number of expansion conferences is called for. The hub conference is linked to the original conference via the reserved port of the original conference and one of the reserved ports of the hub conference.