Abstract: Provided herein is technology relating to identifying the binding locations of DNA-binding proteins and particularly, but not exclusively, to methods, systems, and kits that use affinity reagent-specific barcodes for simultaneously mapping the binding sites of multiple proteins in the same cell.

Abstract: Biomarkers to screen for, identify, and/or characterize lung cancer in a subject are disclosed. Also disclosed herein are methods for distinguishing lung cancer from another disease. Also disclosed herein are methods for detecting metastasis of a lung cancer in a subject. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.

Abstract: Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies.

Abstract: Biomarkers to screen for, identify, and/or characterize lung cancer in a subject with high selectivity and high specificity are disclosed. Also disclosed herein are methods for distinguishing lung cancer from another disease. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.

Abstract: Biomarkers to screen for, identify, and/or characterize lung cancer in a subject are disclosed. Also disclosed herein are methods for distinguishing lung cancer from another disease. Also disclosed herein are methods for detecting metastasis of a lung cancer in a subject. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.

Abstract: This disclosure provides compositions and methods for analyzing a nucleic acid associated with an analyte.

Abstract: Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies.

Abstract: Proximity coupling and sequencing methods to screen, identify, validate and/or characterize interactions between analytes and binding moieties are disclosed. Also disclosed herein are proximity coupling methods and sequencing methods to determine or quantify levels of target analytes. The disclosed methods can be multiplexed in two dimensions, and can be used to determine the affinity and specificity of each of a plurality of binding moieties for each of a plurality of target analytes. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.

Abstract: Proximity coupling and sequencing methods to screen identify, validate and/or characterize interactions between analytes and binding moieties are disclosed. Also disclosed herein are proximity coupling methods and sequencing methods to determine or quantify levels of target analytes. The disclosed methods can be multiplexed in two dimensions, and can be used to determine the affinity and specificity of each of a plurality of binding moieties for each of a plurality of target analytes. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.

Abstract: Provided herein is a system and method for identifying a biomarker and producing a reagent for detecting the biomarker. The system and method comprises administering to an animal a biological sample and comparing the immune response of the animal to the immune response of another animal.

Abstract: Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies.