Patents by Inventor Ignazio Caruana

Ignazio Caruana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CAR-CD30 T cells for treatment of CD30+ tumors
    Patent number: 11845804
    Abstract: A third generation of CAR-CD30 T cells is for treatment of CD30+ Tumors such as lymphoid malignancies, leukemia, and solid tumors. A CD30 chimeric antigen receptor includes, from the N-terminus to the C? terminus, a signal peptide, which is linked by a first linker to an anti CD30 single chain antibody domain from AC10 hybridoma including the AC10 VL sequence and the AC10 VH sequence. The AC10 VL and VH sequences are linked by a second linker.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: December 19, 2023
    Assignee: OSPEDALE PEDIATRICO BAMBINO GESU'
    Inventors: Biagio De Angelis, Concetta Quintarelli, Ignazio Caruana, Franco Locatelli
  • CAR-CD30 T CELLS FOR TREATMENT OF CD30+ TUMORS
    Publication number: 20210206863
    Abstract: A third generation of CAR-CD30 T cells is for treatment of CD30+ Tumors such as lymphoid malignancies, leukemia, solid tumors. A CD30 chimeric antigen receptor includes, from the N-terminus to the C-terminus, a signal peptide, which is linked by a first linker to an anti CD30 single chain antibody domain from AC10 hybridoma including the AC10 VL sequence and the AC10 VH sequence. The AC10 VL and VH sequences are linked by a second linker.
    Type: Application
    Filed: March 12, 2019
    Publication date: July 8, 2021
    Inventors: Biagio DE ANGELIS, Concetta QUINTARELLI, Ignazio CARUANA, Franco LOCATELLI
  • HEPARANASE EXPRESSION IN HUMAN T LYMPHOCYTES
    Publication number: 20160017302
    Abstract: Embodiments of the present disclosure concern improvements to cell therapy for cancer. In certain embodiments, an ex vivo expanded T cell lacks endogenous heparanase expression, and amelioration of this effect allows an improvement for cancer cell therapy, including of solid tumors. In specific embodiments, ex vivo expanded T cells comprise recombinant heparanase expression.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 21, 2016
    Inventors: Gianpietro Dotti, Dario Marchetti, Ignazio Caruana