Patents by Inventor Igor A. Spivak
Igor A. Spivak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170306329Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.Type: ApplicationFiled: July 10, 2017Publication date: October 26, 2017Inventors: Elena Feinstein, Evgenia Alpert, Igor Mett, Amir Bar-Ilan, Igor Spivak, Hagar Kalinski, Natanja Slager
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Patent number: 9701961Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.Type: GrantFiled: August 27, 2015Date of Patent: July 11, 2017Assignee: Quark Pharmaceuticals, Inc.Inventors: Elena Feinstein, Evgenia Alpert, Igor Mett, Amir Bar-Ilan, Igor Spivak, Hagar Kalinski, Natanja Slager
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Publication number: 20150361430Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.Type: ApplicationFiled: August 27, 2015Publication date: December 17, 2015Inventors: Elena Feinstein, Evgenia Alpert, Igor Mett, Amir Bar-Ilan, Igor Spivak, Hagar Kalinski, Natanja Slager
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Patent number: 9121020Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.Type: GrantFiled: March 17, 2014Date of Patent: September 1, 2015Assignee: Quark Pharmaceuticals, Inc.Inventors: Elena Feinstein, Evgenia Alpert, Igor Mett, Hagar Kalinski, Amir Bar-Ilan, Igor Spivak, Natanja Slager
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Patent number: 9089591Abstract: The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.Type: GrantFiled: April 22, 2013Date of Patent: July 28, 2015Assignee: QUARK PHARMACEUTICALS, INC.Inventors: Evgenia Alpert, Igor Spivak, Amir Bar-Ilan
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Publication number: 20150050328Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.Type: ApplicationFiled: March 17, 2014Publication date: February 19, 2015Inventors: Elena FEINSTEIN, Evgenia ALPERT, Igor METT, Hagar KALINSKI, Amir BAR-ILAN, Igor SPIVAK, Netanja SLAGER
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Patent number: 8778904Abstract: The present invention relates to non-invasive methods for treating diseases, disorders and injury to the central nervous system (CNS), and in particular to otic compositions and to methods of use thereof.Type: GrantFiled: December 9, 2010Date of Patent: July 15, 2014Assignee: Quark Pharmaceuticals, Inc.Inventors: Elena Feinstein, Igor Spivak, Evgenia Alpert, Ron Lahav
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Patent number: 8765931Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.Type: GrantFiled: October 22, 2009Date of Patent: July 1, 2014Assignee: Quark Pharmaceuticals, Inc.Inventors: Elena Feinstein, Evgenia Alpert, Igor Mett, Amir Bar-Ilan, Igor Spivak, Hagar Kalinski, Netanja Slager, James D. Thompson
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Publication number: 20140066493Abstract: The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.Type: ApplicationFiled: April 22, 2013Publication date: March 6, 2014Applicant: QUARK PHARMACEUTICALS, INC.Inventors: Evgenia Alpert, Igor Spivak, Amir Bar-Ilan
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Patent number: 8431692Abstract: The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.Type: GrantFiled: June 7, 2009Date of Patent: April 30, 2013Assignee: Quark Pharmaceuticals, Inc.Inventors: Egvenia Alpert, Igor Spivak, Amir Bar-Ilan
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Publication number: 20120252875Abstract: The present invention relates to non-invasive methods for treating diseases, disorders and injury to the central nervous system (CNS), and in particular to otic compositions and to methods of use thereof.Type: ApplicationFiled: December 9, 2010Publication date: October 4, 2012Inventors: Elena Feinstein, Igor Spivak, Evgenia Alpert, Ron Lahav
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Publication number: 20110229557Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.Type: ApplicationFiled: October 22, 2009Publication date: September 22, 2011Inventors: Elena Feinstein, Evgenia Alpert, Igor Mett, Amir Bar-Ilan, Igor Spivak, Hagar Kalinski, Netanja Slager
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Publication number: 20110142917Abstract: The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.Type: ApplicationFiled: June 7, 2009Publication date: June 16, 2011Inventors: Egvenia Alpert, Igor Spivak, Amir Bar-Ilan
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Patent number: 7802069Abstract: A method is provided for protecting flash memory residing on a computing device. The method includes: receiving a data file having a digital signature at a main processor; forwarding the data file from the main processor to a secondary processor for signature validation; validating the digital signature associated with the data file at the secondary processor; enabling a write capability of a flash memory upon successful validation of the digital signature; and writing the data file to the flash memory.Type: GrantFiled: March 7, 2007Date of Patent: September 21, 2010Assignee: Harris CorporationInventors: Mark Chamberlain, Igor A. Spivak
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Publication number: 20080222347Abstract: A method is provided for protecting flash memory residing on a computing device. The method includes: receiving a data file having a digital signature at a main processor; forwarding the data file from the main processor to a secondary processor for signature validation; validating the digital signature associated with the data file at the secondary processor; enabling a write capability of a flash memory upon successful validation of the digital signature; and writing the data file to the flash memory.Type: ApplicationFiled: March 7, 2007Publication date: September 11, 2008Inventors: Mark Chamberlain, Igor A. Spivak