Patents by Inventor Igor Alabugin

Igor Alabugin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10610850
    Abstract: The activation of the C—H bond using low temperature plasma with an inlet liquid stream such that value added products are formed effectively. An organic liquid (e.g., hexane which is immiscible with liquid water) is injected into a flowing gas (argon) stream followed by mixing with a liquid water stream. Thereafter, the mixture contacts a plasma region formed by a pulsed electric discharge. The plasma formed with the flowing liquid and gas between the two electrodes causes chemical reactions that generate various compounds.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: April 7, 2020
    Assignee: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Bruce R. Locke, Igor Alabugin, Robert Wandell, Kevin Hsieh, Stefan Bresch
  • Publication number: 20180099258
    Abstract: The activation of the C—H bond using low temperature plasma with an inlet liquid stream such that value added products are formed effectively. An organic liquid (e.g., hexane which is immiscible with liquid water) is injected into a flowing gas (argon) stream followed by mixing with a liquid water stream. Thereafter, the mixture contacts a plasma region formed by a pulsed electric discharge. The plasma formed with the flowing liquid and gas between the two electrodes causes chemical reactions that generate various compounds.
    Type: Application
    Filed: December 11, 2017
    Publication date: April 12, 2018
    Inventors: Bruce R. LOCKE, Igor Alabugin, Robert Wandell, Kevin Hsieh, Stefan Bresch
  • Patent number: 9861950
    Abstract: The activation of the C—H bond using low temperature plasma with an inlet liquid stream such that value added products are formed effectively. An organic liquid (e.g., hexane which is immiscible with liquid water) is injected into a flowing gas (argon) stream followed by mixing with a liquid water stream. Thereafter, the mixture contacts a plasma region formed by a pulsed electric discharge. The plasma formed with the flowing liquid and gas between the two electrodes causes chemical reactions that generate various compounds.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 9, 2018
    Assignee: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Bruce R. Locke, Igor Alabugin, Robert Wandell, Kevin Hsieh, Stefan Bresch
  • Patent number: 9758499
    Abstract: A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective hydrogen transfer follows a propargyl Claisen rearrangement. Z-Stereochemistry of the first double bond suggests the involvement of a six-membered cyclic intermediate whereas the E-stereochemistry of the second double bond stems from the subsequent protodemetallation step giving an (E,Z)-dienal. The reaction may be represented by the following sequence.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: September 12, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Dinesh V. Vidhani, Marie E. Krafft, Igor Alabugin
  • Publication number: 20170129865
    Abstract: A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective hydrogen transfer follows a propargyl Claisen rearrangement. Z-Stereochemistry of the first double bond suggests the involvement of a six-membered cyclic intermediate whereas the E-stereochemistry of the second double bond stems from the subsequent protodemetallation step giving an (E,Z)-dienal. The reaction may be represented by the following sequence.
    Type: Application
    Filed: January 4, 2017
    Publication date: May 11, 2017
    Inventors: Dinesh V. Vidhani, Marie E. Krafft, Igor Alabugin
  • Patent number: 9598635
    Abstract: A method for the photo-mediated phase transfer of inorganic nanocrystals, such as luminescent quantum dots, QDs, is provided. Irradiation, specifically UV excitation (?ex<400 nm), promotes the in-situ ligand exchange of hydrophobic quantum dots with hydrophilic ligands and their facile transfer to polar solvents and buffer media. The technique enables transfer of quantum dots and other nanocrystal materials from hydrophobic to polar and hydrophilic solutions.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: March 21, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Igor Alabugin, Goutam Palui, Tommaso Avellini
  • Patent number: 9573871
    Abstract: A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective hydrogen transfer follows a propargyl Claisen rearrangement. Z-Stereochemistry of the first double bond suggests the involvement of a six-membered cyclic intermediate whereas the E-stereochemistry of the second double bond stems from the subsequent protodemetallation step giving an (E,Z)-dienal. The reaction may be represented by the following sequence.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: February 21, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Dinesh V. Vidhani, Marie E. Krafft, Igor Alabugin
  • Patent number: 9273023
    Abstract: A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: March 1, 2016
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Philip M. Byers
  • Publication number: 20150361019
    Abstract: A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective hydrogen transfer follows a propargyl Claisen rearrangement. Z-Stereochemistry of the first double bond suggests the involvement of a six-membered cyclic intermediate whereas the E-stereochemistry of the second double bond stems from the subsequent protodemetallation step giving an (E,Z)-dienal. The reaction may be represented by the following sequence.
    Type: Application
    Filed: May 28, 2015
    Publication date: December 17, 2015
    Inventors: Dinesh V. Vidhani, Marie E. Krafft, Igor Alabugin
  • Patent number: 9206100
    Abstract: A method for preparing a cyclobutene compound or a cyclopentenone is provided. The method comprises contacting an ?,?-diketone with a metal acetylide at a temperature below 0° C. to thereby form a reaction mixture comprising a bis-alkyne precursor. The bis-alkyne precursor rearranges into a bis-allenic intermediate, which undergoes further rearrangement into the cyclobutene compound or the cyclopentenone compound as the temperature of the reaction mixture increases from below 0° C. to above 0° C.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: December 8, 2015
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Runa Pal
  • Publication number: 20150073145
    Abstract: A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.
    Type: Application
    Filed: November 14, 2014
    Publication date: March 12, 2015
    Inventors: Igor Alabugin, Philip M. Byers
  • Patent number: 8927778
    Abstract: A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 6, 2015
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Philip M. Byers
  • Patent number: 8927728
    Abstract: Photoreactive DNA cleaving conjugate compounds are provided comprising a DNA cleaving moiety which comprises an aryl alkyne group and a polyfunctional pH-regulated DNA-binding moiety which comprises at least one or two amino groups.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: January 6, 2015
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Wang-Yong Yang, Saumya Roy, Kemal Kaya, Qing-Xiang Sang
  • Publication number: 20140262744
    Abstract: The activation of the C—H bond using low temperature plasma with an inlet liquid stream such that value added products are formed effectively. An organic liquid (e.g., hexane which is immiscible with liquid water) is injected into a flowing gas (argon) stream followed by mixing with a liquid water stream. Thereafter, the mixture contacts a plasma region formed by a pulsed electric discharge. The plasma formed with the flowing liquid and gas between the two electrodes causes chemical reactions that generate various compounds.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Inventors: Bruce R. LOCKE, Igor ALABUGIN, Robert WANDELL, Kevin HSIEH, Stefan BRESCH
  • Publication number: 20130299745
    Abstract: A method for the photo-mediated phase transfer of inorganic nanocrystals, such as luminescent quantum dots, QDs, is provided. Irradiation, specifically UV excitation (?ex<400 nm), promotes the in-situ ligand exchange of hydrophobic quantum dots with hydrophilic ligands and their facile transfer to polar solvents and buffer media. The technique enables transfer of quantum dots and other nanocrystal materials from hydrophobic to polar and hydrophilic solutions.
    Type: Application
    Filed: May 7, 2013
    Publication date: November 14, 2013
    Applicant: The Florida State University Research Foundation Inc.
    Inventors: Hedi Mattoussi, Igor Alabugin, Goutam Palui, Tommaso Avellini
  • Publication number: 20130165683
    Abstract: A method for preparing a cyclobutene compound or a cyclopentenone is provided. The method comprises contacting an ?,?-diketone with a metal acetylide at a temperature below 0° C. to thereby form a reaction mixture comprising a bis-alkyne precursor. The bis-alkyne precursor rearranges into a bis-allenic intermediate, which undergoes further rearrangement into the cyclobutene compound or the cyclopentenone compound as the temperature of the reaction mixture increases from below 0° C. to above 0° C.
    Type: Application
    Filed: September 13, 2011
    Publication date: June 27, 2013
    Inventors: Igor Alabugin, Runa Pal
  • Patent number: 8410303
    Abstract: A method is provided for the preparation of an aromatic carboxylic acid aryl ester or an N-aryl aromatic carboxamide. The method comprises contacting an O,O-diaryl thiocarbonate or an O-aryl-N-aryl thiocarbamate with a reactant that regioselectively reacts with sulfur, which contact causes an O-neophyl rearrangement, thereby forming either the aromatic carboxylic acid aryl ester or the N-aryl aromatic carboxamide, respectively.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: April 2, 2013
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Abdulkader Baroudi
  • Patent number: 8334403
    Abstract: Compounds and methods for double-stranded DNA cleavage of light-activated lysine conjugates are enhanced at the slightly acidic pH suitable for selective targeting of cancer cells by the presence of two amino groups of different basicities. The first amino group plays an auxiliary role enhancing solubility and affinity to DNA whereas the second amino group which is positioned next to the light-activated DNA-cleaver undergoes protonation at the desired pH threshold. Protonation results in two synergetic effects which account for the increased DNA-cleaving ability at the lower pH: tighter binding to DNA at the lower pH; and the unproductive pathway which quenches the excited state of the photocleaver through intramolecular electron transfer is eliminated once the donor amino group next to the chromophore is protonated. The utility of these molecules for phototherapy of cancer is confirmed by the drastic increase in toxicity of five conjugates against cancer cell lines upon photoactivation.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: December 18, 2012
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Serguei Kovalenko, Wang Yong Yang, Kerry Gilmore, Boris Breiner
  • Publication number: 20120288940
    Abstract: Photoreactive DNA cleaving conjugate compounds are provided comprising a DNA cleaving moiety which comprises an aryl alkyne group and a polyfunctional pH-regulated DNA-binding moiety which comprises at least one or two amino groups.
    Type: Application
    Filed: May 7, 2012
    Publication date: November 15, 2012
    Applicant: The Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Wang-Yong Yang, Saumya Roy, Kemal Kaya, Qing-Xiang Sang
  • Publication number: 20110237798
    Abstract: A method is provided for the preparation of an aromatic carboxylic acid aryl ester or an N-aryl aromatic carboxamide. The method comprises contacting an O,O-diaryl thiocarbonate or an O-aryl-N-aryl thiocarbamate with a reactant that regioselectively reacts with sulfur, which contact causes an O-neophyl rearrangement, thereby forming either the aromatic carboxylic acid aryl ester or the N-aryl aromatic carboxamide, respectively.
    Type: Application
    Filed: March 22, 2011
    Publication date: September 29, 2011
    Applicant: The Florida State University Research Foundation, Inc.
    Inventors: Igor Alabugin, Abdulkader Baroudi