Patents by Inventor Igor Galaev

Igor Galaev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090200232
    Abstract: A process for adsorption-based separation of bioparticles from an aqueous suspension containing such bioparticles is disclosed which process comprises a) bringing said aqueous suspension into contact with a macroporous cryogel monolith carrying on its surface a ligand capable of interacting specifically or non-specifically with a receptor on the surface of a bioparticle to be separated to adsorb said bioparticle to said macroporous cryogen monolith; and b) liberating said bioparticle from said macroporous cryogel monolith by elution, wherein said macroporous cryogel monolith is subjected to a physical deformation in conjunction with exposure to eluting medium.
    Type: Application
    Filed: May 11, 2006
    Publication date: August 13, 2009
    Inventors: Bo Mattiasson, Igor Galaev, Ashok Kumar, Maria Dainiak
  • Publication number: 20090170973
    Abstract: A macroporous cryogen is disclosed which has grafted thereon polymer chains formed by polymerizing at least one monomer of the general formula (I) CR1R2=CR3R4 (I) wherein R1 and R2 are equal of different and each represents a hydrogen atom or substituent group which is not detrimental to the polymerization reaction; and R3 and R4 each represents a hydrogen atom or a substituent group which is not detrimental to the polymerization reaction, provided that R3 and R4 are not both a hydrogen atom, on said macroporous cryogel. A method for the preparation of said macroporous cryogel by graft (co)polymerization and the use of said macroporous cryogel in a separation process are also disclosed.
    Type: Application
    Filed: May 11, 2006
    Publication date: July 2, 2009
    Inventors: Bo Mattiasson, Igor Galaev, Irina Savina
  • Patent number: 7547395
    Abstract: A separation medium in macroporous gel form is disclosed which is obtainable by cooling an aqueous solution of at least one gel forming polymer to a temperature, at which the solvent in the system is partially frozen with the dissolved substances concentrated in the non-frozen fraction of the solvent, said gel forming polymer being selected from the group consisting of polymers normally forming gels too fast when an aqueous solution thereof is cooled to a temperature within a range below 0° C. to enable the formation of a cryogel and said cooling being carried out in the presence of at least one chaotropic agent in said aqueous solution in order to prevent gel formation before the polymer solution is frozen. The use of said separation medium for diverse separation purposes is also disclosed.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: June 16, 2009
    Assignee: Protista Biotechnology AB
    Inventors: Bo Mattiasson, Igor Galaev, Vladimir Lozinsky, Fatima Plieva
  • Publication number: 20080090918
    Abstract: A separation medium in macroporous gel form is disclosed which is obtainable by cooling an aqueous solution of at least one gel forming polymer to a temperature, at which the solvent in the system is partially frozen with the dissolved substances concentrated in the non-frozen fraction of the solvent, said gel forming polymer being selected from the group consisting of polymers normally forming gels too fast when an aqueous solution thereof is cooled to a temperature within a range below 0° C. to enable the formation of a cryogel and said cooling being carried out in the presence of at least one chaotropic agent in said aqueous solution in order to prevent gel formation before the polymer solution is frozen. The use of said separation medium for diverse separation purposes is also disclosed.
    Type: Application
    Filed: December 7, 2007
    Publication date: April 17, 2008
    Applicant: PROTISTA BIOTECHNOLOGY AB
    Inventors: Bo Mattiasson, Igor Galaev, Vladimir Lozinsky, Fatima Plieva
  • Publication number: 20070163960
    Abstract: A method for the chromatographic separation of substances contained in a liquid sample is disclosed which method comprises providing a one piece separation tray having a spaced array of discrete identical upstanding chambers each exhibiting an open upper end and an open lower end and a separation medium placed in at least part of each upstanding chamber; applying a liquid sample to said open upper end of at least one of said upstanding chambers; then applying an eluting liquid to said open upper end of said at least one of said upstanding chambers; and collecting at least one product fraction flowing out from the open lower end of said at least one of said upstanding chambers; wherein a monolith of a compressible macroporous gel having in its liquid-swollen, non-compressed state a cross-sectional area which is 2-15%, preferably 4-12% and most preferably 5-10%, larger than the cross-sectional area of the upstanding chamber in which it is placed is used as said separation medium and is in face-to-face contact w
    Type: Application
    Filed: April 1, 2004
    Publication date: July 19, 2007
    Inventors: Bo Mattiasson, Igor Galaev, Rajni Hatti Kaul
  • Publication number: 20050222404
    Abstract: The present invention relates to a method of isolating a desired nucleic acid from a biological solution, which method comprises to selectively precipitate the desired nucleic acid by adding a polycationic precipitating agent to the solution and allowing it to form a complex with said nucleic acid, wherein the precipitating agent is a highly charged linear polymer that comprises quaternary amino groups. The polycationic precipitating agent is preferably added in such an amount that the charge ratio [+]/[?] between polycationic precipitating agent and nucleic acid is ?0.5, preferably ?0.9 and most preferably ?1 during the precipitation, and in the presence of a salt concentration ensuring the quantitative specific precipitation of the nucleic acid/polycation complex.
    Type: Application
    Filed: June 26, 2003
    Publication date: October 6, 2005
    Inventors: Igor Galaev, Per-Erik Gustavsson, Vladimir Izumrudov, Per-Olof Larsson, Per-Olof Wahlund
  • Publication number: 20050029191
    Abstract: A separation medium in macroporous gel form is disclosed which is obtainable by cooling an aqueous solution of at least one gel forming polymer to a temperature, at which the solvent in the system is partially frozen with the dissolved substances concentrated in the non-frozen fraction of the solvent, said gel forming polymer being selected from the group consisting of polymers normally forming gels too fast when an aqueous solution thereof is cooled to a temperature wthin a range below OoC to enable the formation of a cryogel and said cooling being carried out in the presence of at least one chaotropic agent in said aqueous solution in order to prevent gel formation before the polymer solution is frozen. The use of said separation medium for diverse separation purposes is also disclosed.
    Type: Application
    Filed: October 11, 2002
    Publication date: February 10, 2005
    Inventors: Bo Mattiasson, Igor Galaev, Vladimir Lozinsky, Fatima Plieva
  • Publication number: 20050019770
    Abstract: A macroporous gel is disclosed which is obtainable by a) polymerizing an aqueous solution of one or more water-soluble monomers selected from the group consisting of: N-substituted and non-substituted (meth)acrylamides; N-alkyl substituted N-vinylamides; hydroxyalkyl (meth)acrylates; vinylacetate; alkylethers of vinyl alcohol; ringsubstituted styrene derivatives; vinyl monomers; (meth)acrylic acid and salts thereof; silicic acid; and monomers capable of forming polymers via polycondensation, under freezing at a temperature below the solvent crystallization point, at which solvent in the system is partially frozen with the dissolved substances concentrated in the non-frozen fraction of solvent to the formation of a cryogel, and b1) modifying the cryogel by introducing a member selected from the group consisting of ligands, charged groups, dyes and hydrophobic groups thereinto (i) in one or more steps by methods known per se subsequent to thawing of the cryogel or (ii), when appropriate, by using appropriately
    Type: Application
    Filed: October 11, 2002
    Publication date: January 27, 2005
    Inventors: Bo Mattiasson, Igor Galaev, Vladimir Lozinsky, Fatima Plieva
  • Publication number: 20040175788
    Abstract: A method for the separation of at least one low molecular weight bioproduct from a cell culture mixture comprising uni-cellular organisms, broth and said at least one bioproduct by passing said cell culture mixture through a bed of an adsorb-ent material to adsorb said at least one bioproduct on said adsorbent material whereas said unicellular organisms and said broth are passing through said bed, whereafter the ad-sorbed bioproduct or bioproducts is/are eluted from said bed of adsorbent material, wherein said adsorbent material on its surface is provided with a material capable of preventing non-specific adsorption of said unicellular organisms to said adsorbent material.
    Type: Application
    Filed: December 18, 2003
    Publication date: September 9, 2004
    Inventors: Igor Galaev, Rajni Hatti-Kaul, Bo Mattiasson
  • Publication number: 20030105301
    Abstract: A method for the separation of at least one glyco-containing entity, in which method said entity or entities dissolved/suspended in a liquid is/are contacted with a polymer, which has boronic acid covalently coupled to said polymer and previously has been equilibrated with said liquid, to form a boronate-glyco-complex whereafter the glyco-containing entity or entities is/are released from the boronate-modified polymer is disclosed, wherein said liquid contains one or more substances capable of forming complexes with boronic acids/boronate anions, which complexes are weaker than the boronate-glyco-complex but stronger than complexes formed by interactions others than glyco-boronate.
    Type: Application
    Filed: November 5, 2002
    Publication date: June 5, 2003
    Inventors: Yu Cai Li, Igor Galaev, Hans Jungvid, Eva Linne Larsson, Bo Mattlasson
  • Patent number: 6538089
    Abstract: A physically cross-linked copolymer comprising hydrophobic monomers, hydrogen bonding monomers, and thermosensitive monomers, said thermosensitive monomers having a distinct phase change at its lower critical solution temperature (LCST) when existing as a homopolymer. The physically cross-linked copolymer is used for drug delivery system or for enzyme delivery system. The physically cross-linked copolymer is also used for casting shapes of cavities, for production of miniaturized, detailed micro-parts or micro-machine parts, or for production of thermal switches.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: March 25, 2003
    Assignee: Forskarpatent I SYD AB
    Inventors: Babinder Samra, Igor Galaev, Bo Mattiasson