Patents by Inventor Igor Garkavtsev

Igor Garkavtsev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for targeting cancer stem cells
    Patent number: 11427543
    Abstract: This invention relates to antagonists of G3BP2, G3BP1, and ZEB1. Pharmaceutical compositions comprising G3BP2 inhibitors, methods of inhibiting G3BP2, G3BP1, and ZEB1, methods of treating cancer and inflammation, and methods of identifying an inhibitor of cancer stems cells are also provided.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: August 30, 2022
    Assignee: The General Hospital Corporation
    Inventors: Igor Garkavtsev, Rakesh K. Jain
  • Compounds for inhibiting secretory leukocyte protease inhibitor (SLPI)
    Patent number: 11351144
    Abstract: This invention relates to compounds that are useful for inhibiting the secretion of secretory leukocyte protease inhibitor (SLPI) in a subject. Methods of inhibiting metastasis of cancer and methods of treating cancer in a subject are also provided.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: June 7, 2022
    Assignee: The General Hospital Corporation
    Inventors: Igor Garkavtsev, Rakesh K. Jain
  • Compounds for Targeting Cancer Stem Cells
    Publication number: 20210238140
    Abstract: This invention relates to antagonists of G3BP2, G3BP1, and ZEB1. Pharmaceutical compositions comprising G3BP2 inhibitors, methods of inhibiting G3BP2, G3BP1, and ZEB1, methods of treating cancer and inflammation, and methods of identifying an inhibitor of cancer stems cells are also provided.
    Type: Application
    Filed: July 18, 2017
    Publication date: August 5, 2021
    Inventors: Igor Garkavtsev, Rakesh K. Jain
  • Compounds For Inhibiting Secretory Leukocyte Protease Inhibitor (SLPI)
    Publication number: 20210196666
    Abstract: This invention relates to compounds that are useful for inhibiting the secretion of secretory leukocyte protease inhibitor (SLPI) in a subject. Methods of inhibiting metastasis of cancer and methods of treating cancer in a subject are also provided.
    Type: Application
    Filed: October 9, 2018
    Publication date: July 1, 2021
    Inventors: Igor Garkavtsev, Rakesh K. Jain
  • TREATMENT OF ANGIOGENIC- OR VASCULAR-ASSOCIATED DISEASES
    Publication number: 20140161720
    Abstract: Described herein are methods and compositions comprising a compound of formula (I), e.g., dehydro-alpha-lapachone, or an analog, derivative, isomer, prodrug, or pharmaceutically acceptable salt thereof, for treatment and/or prevention of angiogenic- or vascular-associated diseases or disorders. The compound has anti-vascular activity. In some embodiments, the compound has anti-vascular activity that targets pathways other than VEGF pathways. In some embodiments, the compound or the composition further comprises anti-tumor activity. In some embodiments, the compound or the composition can decrease adhesion or motility of at least one cell (e.g., endothelial cells or cancer cells).
    Type: Application
    Filed: May 25, 2012
    Publication date: June 12, 2014
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Igor Garkavtsev, Rakesh K. Jain
  • Antibodies against the tumor suppressor gene ING1
    Patent number: 6747133
    Abstract: The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related tumor suppressor proteins and peptides.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: June 8, 2004
    Assignee: University Technologies International Inc.
    Inventors: Igor Garkavtsev, Karl Riabowol
  • Method of modulating p53 activity
    Patent number: 6420136
    Abstract: This invention relates to a method for modulating the activity of the protein p53 in cells by the addition of a peptide or protein having p33ING1 biological activity or a nucleic acid coding for such a peptide or protein.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: July 16, 2002
    Assignees: University Technologies International, Inc., Board of Trustees of the University of Illinois
    Inventors: Karl T. Riabowol, Igor Garkavtsev, Andrei Gudkov
  • DNA sequence encoding the tumor suppressor gene ING1
    Patent number: 6238918
    Abstract: The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related tumor suppressor proteins and peptides.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: May 29, 2001
    Assignee: University Technologies International, Inc.
    Inventors: Igor Garkavtsev, Karl Riabowol
  • Methods of modulating apoptosis
    Patent number: 6143522
    Abstract: The invention provides novel methods for modulating apoptosis in eukaryotic cells using peptides and proteins derived from p33.sup.ING1 or oligonucleotides derived from the ING1 gene. The invention also provides method of determining the apoptotic characteristic of a eukaryotic cell.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: November 7, 2000
    Assignee: University Technologies International, Inc.
    Inventors: Caren C. Helbing, Karl Riabowol, Randall N. Johnston, Igor Garkavtsev
  • DNA sequence encoding the tumor suppressor gene ING1
    Patent number: 6117633
    Abstract: The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related tumor suppressor proteins and peptides.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: September 12, 2000
    Assignees: University Technologies International Inc., University of Illinois
    Inventors: Igor Garkavtsev, Karl Riabowol, Andrei Gudkov
  • DNA sequence encoding a tumor suppressor gene
    Patent number: 6037121
    Abstract: The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related tumor suppressor proteins and peptides.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: March 14, 2000
    Assignees: University Technologies International Inc., University of Illinois
    Inventors: Igor Garkavtsev, Karl Riabowol, Andrei Gudkov
  • DNA sequence encoding the tumor suppressor gene ING1
    Patent number: 5986078
    Abstract: The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related tumor suppressor proteins and peptides.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: November 16, 1999
    Assignee: University Technologies International Inc.
    Inventors: Igor Garkavtsev, Karl Riabowol
  • DNA sequence encoding a tumor suppressor gene
    Patent number: 5965398
    Abstract: The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related tumor suppressor proteins and peptides.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: October 12, 1999
    Assignee: University Technologies International Inc.
    Inventors: Igor Garkavtsev, Karl Riabowol