Abstract: The present disclosure provides methods of producing hepatocytes from induced pluripotent stem cells. Further provided herein are methods of using the hepatocytes for the treatment of a liver disease.

Abstract: An apparatus comprises a display screen, and an optical sensor module which is disposed behind the display screen. The optical sensor module further comprises a light emitter operable to generate light having a wavelength for transmission through the display screen toward a target object. A light sensor is operable to sense light reflected by the target object and having the wavelength. A reducer is arranged for reducing the optical power density by increasing a diameter of a light beam generated by the light emitter on the display screen, wherein the reducer is disposed between the light emitter and the display screen so as to intersect the light beam generated by the light emitter.

Abstract: A lighting apparatus is disclosed with a light generating device, at least one collimator lens, first and second parabolic mirrors, an optical diaphragm embodied in a light reflecting fashion, and a spherical mirror. The diaphragm is arranged between the parabolic mirrors, extending as far as a common focus of them. The parabolic mirror, the device and the lens are arranged so that light emitted by the device and collimated by the lens is directed onto the first parabolic mirror reflection surface and light reflected by the first parabolic mirror reflection surface impinges on the second parabolic mirror reflection surface or on the diaphragm. The spherical mirror is arranged so that its focus is arranged at the common focus of the parabolic mirrors and light reflected at the diaphragm impinges on the spherical mirror reflection surface and is directed from the reflection surface onto the second parabolic mirror reflection surface.

Abstract: Proposed is a beam shaper for beams emitted from at least one laser-diode bar and consisting of a fast-axis collimator composed of a common cylindrical lens with an aspherical profile, an array of spherical/aspherical telescope units formed from a pair of microlenses, where each individual telescope unit is shifted in accordance with a predetermined law to a certain distance relative to a neighboring individual telescope unit, an array of cylindrical lenses shifted relative to each other in accordance with another predetermined law, and a system of collimation lenses that collimate the beams of the predetermined spatial pattern into a two-dimensional pattern having a less discrete and more uniform distribution of light intensity and a shape more convenient for subsequent coupling, e.g., for focusing into the end face of an optical fiber of a light transmission system.

Abstract: Proposed is a beam shaper for beams emitted from at least one laser-diode bar and consisting of a fast-axis collimator composed of a common cylindrical lens with an aspherical profile, an array of spherical/aspherical telescope units formed from a pair of microlenses, where each individual telescope unit is shifted in accordance with a predetermined law to a certain distance relative to a neighboring individual telescope unit, an array of cylindrical lenses shifted relative to each other in accordance with another predetermined law, and a system of collimation lenses that collimate the beams of the predetermined spatial pattern into a two-dimensional pattern having a less discrete and more uniform distribution of light intensity and a shape more convenient for subsequent coupling, e.g., for focusing into the end face of an optical fiber of a light transmission system.

Abstract: An EUV lithography system 1 comprises an EUV beam path and a monitor beam path 51. The EUV beam path comprises a mirror system 13, which has a base and a multiplicity of mirror elements 17 having concave mirror surfaces, the orientation of which relative to the base is respectively adjustable. The monitor beam path 51 comprises at least one monitor radiation source 53, a screen 71, the mirror system 13, which is arranged in the monitor beam path 51 between the monitor radiation source 53 and the screen 71, and a spatially resolving detector 77. In this case, each of a plurality of the mirror elements generates an image of the monitor radiation source in an image plane assigned to the respective mirror elements, distances B between the image planes assigned to the mirror elements and the screen have a maximum distance, distances A between each of the plurality of mirror elements and the image plane assigned to it have a minimum distance, and the maximum distance B is less than half of the minimum distance A.

Abstract: An EUV lithography system 1 comprises an EUV beam path and a monitor beam path 51. The EUV beam path comprises a mirror system 13, which has a base and a multiplicity of mirror elements 17 having concave mirror surfaces, the orientation of which relative to the base is respectively adjustable. The monitor beam path 51 comprises at least one monitor radiation source 53, a screen 71, the mirror system 13, which is arranged in the monitor beam path 51 between the monitor radiation source 53 and the screen 71, and a spatially resolving detector 77. In this case, each of a plurality of the mirror elements generates an image of the monitor radiation source in an image plane assigned to the respective mirror elements, distances B between the image planes assigned to the mirror elements and the screen have a maximum distance, distances A between each of the plurality of mirror elements and the image plane assigned to it have a minimum distance, and the maximum distance B is less than half of the minimum distance A.

Abstract: A fiber-bundle illumination system of high brightness with reduced optical losses comprises a plurality of light sources that emit lights of different colors and transmit the component lights of different colors to a light mixer through individual optical-fiber light guides assembled into a bundle, which is crimped at least at the inlet and outlet ends. Unique features of the system are optical coupling between the light sources and their respective light guides and mixing colors in a predetermined proportion that results in spatially uniform distribution of the spectrum on the illuminated area. The system may be used in conjunction with optical instruments such as endoscopic cameras, microscopes, etc.

Abstract: The optical signal multiplexer/demultiplexer of the invention is characterized by incorporating a bidirectional optical transceiver which is capable of using individual channels working in a transmitting and receiving modes simultaneously. The device consists of a number of optical prisms combined into a single module and provided with appropriate dichroic mirrors and interferrometric filters located on the outer surfaces of the prisms. According to one embodiment of the invention, the module consists of two sequentially arranged parallelogram prisms, a single-channel signal input/output unit with an optical collimator/focusator on one side of the prism module and a two-channel signal output/input unit with a respective optical collimator/focusator on the other side of the prism module.

Abstract: An ultra-thin digital imaging device has a thickness of several millimeters and is capable of producing data for creating images of 3 Mp and higher. The device comprises a multi-channel imaging unit that contains a plurality of optical channels formed by microlens objectives and a pixilated image sensor unit with a plurality of sensing elements. Each individual identical image obtained through each optical channel is pixilated and converted into electrical signals that are processed into data sets which can be stored in the imaging device and either reproduced on the display of the device or transmitted to an external image-reproducing device where the obtained data of individual images are transformed into a single, high-resolution megapixel image by means of a technique known in the art.

Abstract: The optical system of the invention is comprised of a monolithic microlens array assembly that consists of two groups of microlenses sub-assemblies having different pitches between the adjacent lenses. A ratio between the pitches of sub-assemblies is determined by a predetermined relationship between the parameters of the optical system so that the microlenses of the first sub-assembly create a plurality of individual intermediate images arranged side-by-side in a common intermediate plane that are transferred by the microlenses of the second sub-assembly to the final image plane in the form of a plurality of identical and accurately registered images interposed onto each other. This is achieved due to the aforementioned ratio between the pitches.

Abstract: The optical system of the invention is comprised of a monolithic microlens array assembly that consists of two groups of microlenses sub-assemblies having different pitches between the adjacent lenses. A ratio between the pitches of sub-assemblies is determined by a predetermined relationship between the parameters of the optical system so that the microlenses of the first sub-assembly create a plurality of individual intermediate images arranged side-by-side in a common intermediate plane that are transferred by the microlenses of the second sub-assembly to the final image plane in the form of a plurality of identical and accurately registered images interposed onto each other. This is achieved due to the aforementioned ratio between the pitches.

Abstract: A thin monolithic image sensor of the invention is comprised of a laminated solid package composed essentially of an optical layer and an image-receiving layer placed on the top of the optical layer. The optical layer also comprises a laminated structure composed of at least an optical microlens-array sublayer and an aperture-array sublayer. The image-receiving layer is a thin flat CCD/CMOS structure that may have a thickness of less than 1 mm. The image digitized by the CCD/CMOS structure of the sensor can be transmitted from the output of the image-receiving layer to a CPU for subsequent processing and, if necessary, for displaying. A distinguishing feature of the sensor of the invention is that the entire sensor along with a light source has a monolithic structure, and that the diaphragm arrays are located in planes different from the plane of the microlens array and provide the most efficient protection against overlapping of images produced by neighboring microlenses.

Abstract: A flat wide-angle lens system of the invention has a reduced axial length and is intended for creating images with extremely wide angle of observation. The system consists of the first component which is intended for reduction of the field angle of light incidence onto the objective and comprises an assembly of at least two microlens arrays with the same pitch between the adjacent microlenses and arranged with respect to each other so as to provide afocality, and a second component that comprises an assembly of conventional spherical or aspherical microlenses that create an image on an image receiver. Each two coaxial microlenses of the microlens arrays of the first component form an inverted microtelescope of Galileo. The outlet aperture of a single microtelescope is made so that spherical aberration can be minimized almost to 0, while field aberrations can be corrected by design parameters of the microlenses.

Abstract: A flat wide-angle lens system of the invention has a reduced axial length and is intended for creating images with extremely wide angle of observation. The system consists of the first component which is intended for reduction of the field angle of light incidence onto the objective and comprises an assembly of at least two microlens arrays with the same pitch between the adjacent microlenses and arranged with respect to each other so as to provide afocality, and a second component that comprises an assembly of conventional spherical or aspherical microlenses that create an image on an image receiver. Each two coaxial microlenses of the microlens arrays of the first component form an inverted microtelescope of Galileo. The outlet aperture of a single microtelescope is made so that spherical aberration can be minimized almost to 0, while field aberrations can be corrected by design parameters of the microlenses.

Abstract: A flat wide-angle objective of the invention consists of a first sub-unit that is located on the object side of the objective and includes an assembly of two conventional aspheric negative, plano-concave lenses, and a second sub-unit in the form of a set of four microlens arrays arranged on the image-receiving side of the objective. The microlenses of all microlens arrays have the same arrangement of microlenses in all the arrays. A diaphragm array with restricting openings can be sandwiched between a pair of the microlens arrays. The invention makes it possible to reduce longitudinal dimension of the objective. In operation, the first sub-unit creates an imaginary image of the object in its focal plane, which is located on object side of the objective, while the second sub-unit creates an actual image of the object in the image plane on the image-receiving side of the objective.

Abstract: A flat wide-angle objective of the invention consists of a first sub-unit that is located on the object side of the objective and comprises an assembly of two conventional aspheric negative, e.g., aspheric piano-concave lenses, and a second sub-unit in the form of a set of four microlens arrays arranged on the image-receiving side of the objective. The microlenses of all microlens arrays have the same arrangement of microlenses in all the arrays. A diaphragm array with restricting openings can be sandwiched between a pair of the microlens arrays. The objective of the invention can be realized into an optimal design only with predetermined relationships between the parameters of the optical system that forms the objective. The invention makes it possible to drastically reduce longitudinal dimension of the objective.

Abstract: The optical module of the invention for high-speed bidirectional transceiver consists of a signal receiving unit, a signal transmitting unit, a common receiving-transmitting optical fiber, and a fiber coupling unit. The laser diode and the photodiode are arranged parallel to each other in closely located recesses of the module housing. Such an arrangement makes it possible to shorten distances for guiding lead wires from the terminals of the PC board to the respective terminals of the transmitting and receiving diodes. The laser diode emits a first transmitting laser beam that passes through a microobjective that collimates the beam and directs into onto a full-reflection mirror located inside the module housing. The full-reflection mirror reflects the first transmitting beam at an angle of 90° and transmits it to the end face of an optical fiber through an optical fiber collimator that centers the beam with the fiber core.

Abstract: The optical signal multiplexer/demultiplexer of the invention is characterized by incorporating a bidirectional optical transceiver which is capable of using individual channels working in a transmitting and receiving modes simultaneously. The device consists of a number of optical prisms combined into a single module and provided with appropriate dichroic mirrors and interferrometric filters located on the outer surfaces of the prisms. According to one embodiment of the invention, the module consists of two sequentially arranged parallelogram prisms, a single-channel signal input/output unit with an optical collimator/focusator on one side of the prism module and a two-channel signal output/input unit with a respective optical collimator/focusator on the other side of the prism module.

Abstract: The optical module of the invention for high-speed bidirectional transceiver consists of a signal receiving unit, a signal transmitting unit, a common receiving-transmitting optical fiber, and a fiber coupling unit. The laser diode and the photodiode are arranged parallel to each other in closely located recesses of the module housing. Such an arrangement makes it possible to shorten distances for guiding lead wires from the terminals of the PC board to the respective terminals of the transmitting and receiving diodes. The laser diode emits a first transmitting laser beam that passes through a microobjective that collimates the beam and directs into onto a full-reflection mirror located inside the module housing. The full-reflection mirror reflects the first transmitting beam at an angle of 90° and transmits it to the end face of an optical fiber through an optical fiber collimator that centers the beam with the fiber core.