Patents by Inventor Igor Lokot

Igor Lokot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210186879
    Abstract: A pharmaceutical composition in form of an aqueous suspension up to a size of 200 ?m comprises or consists of amphiphilic sulfonate and/or sulfate of a hydrophilic cancer drug having a solubility in water or aqueous body fluid of less than 0.1% by weight. Also disclosed are the particles in powderous form, methods for their production and for the production of the suspension, a method of treating cancer, bacterial or fungal infections in lung by administration of the pharmaceutical composition, and a method of designing a composition according to the invention.
    Type: Application
    Filed: March 3, 2017
    Publication date: June 24, 2021
    Inventor: Igor LOKOT
  • Patent number: 10973772
    Abstract: A method of designing a pharmaceutical composition for providing the liver of a person or animal, as a therapeutic target, with a predetermined concentration of a sulfate or sulfonate of a pharmacologically active agent, during a predetermined period, includes determining the correlation between the solubility of a sulfate and/or sulfonate of a pharmacologically active agent of the formula Dn+(R1SO3)?n or Dn+(R2OSO3)?n for various carbon chain lengths X, Y in an aqueous solvent and the expected concentration of the pharmaceutically active agent D in the therapeutic target upon administration of the pharmacologically active agent D to the person or animal, defining a target solubility of the sulfate or sulfonate based on a desired concentration of said pharmaceutically active substance D in the therapeutic target, and determining the carbon chain length(s) X, Y corresponding to the target solubility.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: April 13, 2021
    Assignee: DOUBLE BOND PHARMACEUTICALS AB
    Inventor: Igor Lokot
  • Publication number: 20190046462
    Abstract: A method of designing a pharmaceutical composition for providing the liver of a person or animal, as a therapeutic target, with a predetermined concentration of a sulfate or sulfonate of a pharmacologically active agent, during a predetermined period, includes determining the correlation between the solubility of a sulfate and/or sulfonate of a pharmacologically active agent of the formula Dn+(R1SO3)?n or Dn+(R2OSO3)?n for various carbon chain lengths X, Y in an aqueous solvent and the expected concentration of the pharmaceutically active agent D in the therapeutic target upon administration of the pharmacologically active agent D to the person or animal, defining a target solubility of the sulfate or sulfonate based on a desired concentration of said pharmaceutically active substance D in the therapeutic target, and determining the carbon chain length(s) X, Y corresponding to the target solubility.
    Type: Application
    Filed: July 17, 2018
    Publication date: February 14, 2019
    Inventor: Igor LOKOT
  • Patent number: 10034838
    Abstract: A pharmaceutical composition in form of an aqueous colloid or an aqueous suspension of particles up to a size of 100 ?m comprises or consists of amphiphilic sulfonate or sulfate of a hydrophilic cancer drug having a solubility in water or aqueous body fluid of less than 0.1% by weight. Also disclosed are the particles in powderous form, methods for their production and for the production of the colloid and the courser suspension, a method of treating liver cancer, in particular solid liver cancer tumours, by administration of the pharmaceutical composition, and a method of designing a composition according to the invention.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: July 31, 2018
    Assignee: DOUBLE BOND PHARMACEUTICALS AB
    Inventor: Igor Lokot
  • Patent number: 9993438
    Abstract: This invention relates to a drug delivery system for administration of poorly water soluble pharmaceutically active substance, a pharmaceutical composition comprising such a drug delivery system, and a method for the preparation of such a drug delivery system. The invention also relates to a method for controlling the particle size and/or particle shape and/or particle size distribution in such a drug delivery system, and to a method for increasing the drug loading capacity of the particles. Furthermore the invention also relates to the use of such a drug delivery system for the preparation of a medicament for the treatment of cancer.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: June 12, 2018
    Assignee: Ardenia Investments, Ltd.
    Inventors: Julian Aleksov, Igor Lokot
  • Publication number: 20170239192
    Abstract: A pharmaceutical composition in form of an aqueous colloid or an aqueous suspension of particles up to a size of 100 ?m comprises or consists of amphiphilic sulfonate or sulfate of a hydrophilic cancer drug having a solubility in water or aqueous body fluid of less than 0.1% by weight. Also disclosed are the particles in powderous form, methods for their production and for the production of the colloid and the courser suspension, a method of treating liver cancer, in particular solid liver cancer tumours, by administration of the pharmaceutical composition, and a method of designing a composition according to the invention.
    Type: Application
    Filed: September 9, 2015
    Publication date: August 24, 2017
    Inventor: Igor LOKOT
  • Publication number: 20150164819
    Abstract: This invention relates to a drug delivery system for administration of poorly water soluble pharmaceutically active substance, a pharmaceutical composition comprising such a drug delivery system, and a method for the preparation of such a drug delivery system. The invention also relates to a method for controlling the particle size and/or particle shape and/or particle size distribution in such a drug delivery system, and to a method for increasing the drug loading capacity of the particles. Furthermore the invention also relates to the use of such a drug delivery system for the preparation of a medicament for the treatment of cancer.
    Type: Application
    Filed: February 27, 2015
    Publication date: June 18, 2015
    Inventors: Julian ALEKSOV, Igor LOKOT
  • Patent number: 8999382
    Abstract: This invention relates to a drug delivery system for administration of poorly water soluble pharmaceutically active substance, a pharmaceutical composition comprising such a drug delivery system, and a method for the preparation of such a drug delivery system. The invention also relates to a method for controlling the particle size and/or particle shape and/or particle size distribution in such a drug delivery system, and to a method for increasing the drug loading capacity of the particles. Furthermore the invention also relates to the use of such a drug delivery system for the preparation of a medicament for the treatment of cancer.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: April 7, 2015
    Assignee: Ardenia Investments, Ltd.
    Inventors: Julian Aleksov, Igor Lokot
  • Patent number: 8765173
    Abstract: A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises poorly water soluble nanoparticles formed by the API together with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: July 1, 2014
    Assignee: Ardenia Investments, Ltd.
    Inventors: Julian Aleksov, Igor Lokot
  • Patent number: 8324274
    Abstract: A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises amorphous particles of <100 nm of a poorly water soluble complex of the API with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester, which particles are entrapped in nanoparticles formed a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester, the w/w-ratio of Na-salt of N-alltrans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester to the complex is about 0.5:1 to about 20:1. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: December 4, 2012
    Assignee: Ardenia Invesments, Ltd.
    Inventors: Julian Aleksov, Igor Lokot
  • Publication number: 20110236472
    Abstract: A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises amorphous particles of <100 nm of a poorly water soluble complex of the API with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester, which particles are entrapped in nanoparticles formed a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester, the w/w-ratio of Na-salt of N-alltrans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester to the complex is about 0.5:1 to about 20:1. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer.
    Type: Application
    Filed: December 18, 2008
    Publication date: September 29, 2011
    Applicant: ARDENIA INVESTMENTS, INC.
    Inventors: Julian Aleksov, Igor Lokot
  • Publication number: 20110123607
    Abstract: A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises poorly water soluble nanoparticles formed by the API together with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer.
    Type: Application
    Filed: December 18, 2008
    Publication date: May 26, 2011
    Inventors: Julian Aleksov, Igor Lokot
  • Publication number: 20110014281
    Abstract: This invention relates to a drug delivery system for administration of poorly water soluble pharmaceutically active substance, a pharmaceutical composition comprising such a drug delivery system, and a method for the preparation of such a drug delivery system. The invention also relates to a method for controlling the particle size and/or particle shape and/or particle size distribution in such a drug delivery system, and to a method for increasing the drug loading capacity of the particles. Furthermore the invention also relates to the use of such a drug delivery system for the preparation of a medicament for the treatment of cancer.
    Type: Application
    Filed: December 18, 2008
    Publication date: January 20, 2011
    Inventors: Julian Aleksov, Igor Lokot
  • Patent number: RE49741
    Abstract: This invention relates to a drug delivery system for administration of poorly water soluble pharmaceutically active substance, a pharmaceutical composition comprising such a drug delivery system, and a method for the preparation of such a drug delivery system. The invention also relates to a method for controlling the particle size and/or particle shape and/or particle size distribution in such a drug delivery system, and to a method for increasing the drug loading capacity of the particles. Furthermore the invention also relates to the use of such a drug delivery system for the preparation of a medicament for the treatment of cancer.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: December 5, 2023
    Assignee: Vivesto AB
    Inventors: Julian Aleksov, Igor Lokot
  • Patent number: RE49742
    Abstract: This invention relates to a drug delivery system for administration of poorly water soluble pharmaceutically active substance, a pharmaceutical composition comprising such a drug delivery system, and a method for the preparation of such a drug delivery system. The invention also relates to a method for controlling the particle size and/or particle shape and/or particle size distribution in such a drug delivery system, and to a method for increasing the drug loading capacity of the particles. Furthermore the invention also relates to the use of such a drug delivery system for the preparation of a medicament for the treatment of cancer.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: December 5, 2023
    Assignee: Vivesto AB
    Inventors: Julian Aleksov, Igor Lokot