Abstract: Particles are separated, concentrated, or mixed within a fluid by means of a fluid-containing cell having a longitudinal axis, a cross-sectional area generally perpendicular to the longitudinal axis, and at least one particle motivating force directionally interacting with at least one recurrent circulating fluid flow generally aligned with the longitudinal axis within the fluid containing cell.

Abstract: Particles are separated, concentrated, or mixed within a fluid by means of a fluid-containing cell having a longitudinal axis, a cross-sectional area generally perpendicular to the longitudinal axis, and at least one particle motivating force directionally interacting with at least one recurrent circulating fluid flow generally aligned with the longitudinal axis within the fluid containing cell.

Abstract: An apparatus and method to achieve manipulation of particles and/or solutions through the induction of electromagnetic fields inside liquid contained inside vessels are disclosed. A “vessel” denotes specifically either a microtitter plate (microplate or well-plate, 1536, 3456 or any other format) well or hybridization solution placed on microarrays for hybridization experiment purposes or more generally any volume containing liquid solution. The manipulation is performed by bringing the active part of the device into contact with the fluidic solution, wherein electromagnetic fields and/or induced fluid flow are used to perform specific manipulations including transport, separation, concentration, mixing, reaction and electroporation. The invention can be used to enhance processing in a number of standard assays and protocols, including the Polymerase Chain Reaction, kinase-based assays, ELISA assays and electroporation.

Abstract: A software-driven device named the Microfluidic Central Processing Unit (?fCPU). The device is a chamber encompassing a contiguous physical volume equipped with actuators (electrodes, pressure membranes or other) capable of inducing physical forces on liquids, gases and particles contained in it, for the purpose of performing at least the 5 basic microfluidics operations: mixing, concentration, separation, transport and reaction within one integrated chamber. The device can have one volume where all of the operations are performed or can be spatially divided into several “processing areas” between which there are transport routes enabled by the software-regulated actuation. A device that contains more than one ?fCPU employed in parallel or in series or both. A device that is composed of one or more than one ?fCPU's and where fluids and particles are transported using a central pump together with integrated micropumps.

Abstract: Microscale or nanoscale apparatus for stopped-flow, quenched flow or continuous flow reaction apparatus where fluids or gases are mixed in a device composed of parallel or serial assembly of the basic fluid-containing cell having a longitudinal axis, a cross-sectional area generally perpendicular to the longitudinal axis, and at least one connected crossing cell having a longitudinal axis, a cross-sectional area generally perpendicular to said longitudinal axis and a fluid motivating force interacting transversally with the fluids flow.

Abstract: An apparatus, a method and a process to achieve manipulation of particles and/or solutions through the use of electrokinetic properties are disclosed. The manipulation is performed using a disposable device positioned on top of a stage for purposes of powering the electrodes. The fluidic solution is brought into contact with the active part of the device and then manipulated.

Abstract: Particles are separated, concentrated, or mixed within a fluid by means of a fluid-containing cell having a longitudinal axis, a cross-sectional area generally perpendicular to the longitudinal axis, and at least one particle motivating force directionally interacting with at least one recurrent circulating fluid flow generally aligned with the longitudinal axis within the fluid containing cell.

Abstract: A mixing apparatus is used to effect mixing between one or more fluid streams. The mixing apparatus generally functions by creating a transverse flow component in the fluid flowing within a channel without the use of moving mixing elements. The transverse or helical flow component of the flowing fluid or fluids can be created by weak modulations of the shape of the walls of the channel. Transverse or helical flow component can be created by grooves features defined on the channel wall. Specifically, the present invention can be used in laminarly flowing fluids. The mixing apparatus and methods thereof can effect mixing of a fluid or fluids flowing with a Reynolds number of less than about 100. Thus, the present invention can be used to mix a fluid flowing in the micro-regime. The mixing apparatus can be used to mix a fluid in a microfluidic system to significantly reduce the Taylor dispersion along the principal direction.