Patents by Inventor Igor Mikhailopulo

Igor Mikhailopulo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biocatalytic synthesis of aminodeoxy purine N9-beta-D-nucleosides containing 3-amino-3-deoxy-beta-D-ribofuranose, 3-amino-2,3-dideoxy-beta-D-ribofuranose, and 2-amino-2-deoxy-beta-D-ribofuranose as sugar moieties
    Publication number: 20070065922
    Abstract: Purine N9-?-D-nucleosides containing 3-amino-3-deoxy-?-D-ribofaranose, 3-amino-2,3-dideoxy-?-D-ribofuranose, and 2-amino-2-deoxy-?-D-ribofuranose as sugar moieties are synthesized by biocatalytic transglycosylation of purine bases and the respective 3?-amino-3?-deoxyuridine, 3?-amino-3?-deoxythymidine and 2?-amino-2?-deoxyuridine as donors of the carbohydrate moiety, and the cells of Escherichia coli as a biocatalyst or glutaraldehyde (GA) treated cells of Escherichia coli as a biocatalyst or a mixture of thymidine (uridine) phosphorylase and purine nucleoside phosphorylase.
    Type: Application
    Filed: November 29, 2005
    Publication date: March 22, 2007
    Applicant: Metkinen Oy
    Inventors: Vladimir Barai, Ludmilla Eroshevskaya, Igor Mikhailopulo, Alex Azhayev, Seppo Lapinjoki
  • (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
    Patent number: 5571799
    Abstract: The invention deals with the production of analogues of adenylyl (2'-5')adenylyl (2'-5')-9-(2,3-anhydro-.beta.-D-ribofuranosyl) adenine disodium salt by the phosphotriester method. The pharmaceutical composition prepared according to this invention inhibits the host-vs.-graft response.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: November 5, 1996
    Assignee: Basco, Ltd.
    Inventors: Zenovy Tkachuk, Eugeny Kvasyuk, Gennady Matsuka, Igor Mikhailopulo