Patents by Inventor Igor Nikoulin

Igor Nikoulin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPOSOMAL ANTICANCER COMPOSITIONS
    Publication number: 20210205245
    Abstract: Provided herein includes methods and compositions for the treatment of cancer. Described herein are liposome encapsulated chemotherapeutic agents and methods for preparing and utilizing the same.
    Type: Application
    Filed: February 11, 2021
    Publication date: July 8, 2021
    Inventors: Igor Nikoulin, Gerald Yakatan, Yevgeniya Plekhov, Robert Giannini
  • Liposomal anticancer compositions
    Patent number: 11033520
    Abstract: Provided herein includes methods and compositions for the treatment of cancer. Described herein are liposome encapsulated chemotherapeutic agents, encompassing a weakly basic anticancer compound and an acid or salt thereof, wherein the acid is oxalic acid or tartaric acid and methods for preparing and utilizing the same.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: June 15, 2021
    Assignee: IRISYS, INC.
    Inventors: Igor Nikoulin, Gerald Yakatan, Yevgeniya Plekhov, Robert Giannini
  • Solubilization of pterostilbene and resveratrol for aqueous beverages
    Patent number: 10703699
    Abstract: In one embodiment, the present application discloses compositions and methods of solubilizing pterostilbene or resveratrol, or mixture thereof in aqueous media.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: July 7, 2020
    Assignee: Ironstone Separations, Inc.
    Inventors: James D. McChesney, Igor Nikoulin, Douglas L. Rodenburg
  • LIPSOMAL ANTICANCER COMPOSITIONS
    Publication number: 20190269635
    Abstract: Provided herein includes methods and compositions for the treatment of cancer. Described herein are liposome encapsulated chemotherapeutic agents, encompassing a weakly basic anticancer compound and an acid or salt thereof, wherein the acid is oxalic acid or tartaric acid and methods for preparing and utilizing the same.
    Type: Application
    Filed: September 1, 2017
    Publication date: September 5, 2019
    Inventor: Igor Nikoulin
  • Nanoparticulate compositions for targeted delivery of acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation
    Patent number: 10369105
    Abstract: In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: August 6, 2019
    Assignee: Veiled Therapeutics LLC
    Inventors: James D. McChesney, Igor Nikoulin, Steve J. Bannister, Douglas L. Rodenburg
  • Nanoparticulate compositions for targeted delivery of acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation
    Patent number: 10064823
    Abstract: In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: September 4, 2018
    Assignee: Veiled Therapeutics LLC
    Inventors: James D. McChesney, Igor Nikoulin, Steve J. Bannister, Douglas L. Rodenburg
  • Nanoparticulate Compositions for Targeted Delivery of Acid Labile, Lipophilic Prodrugs of Cancer Chemotherapeutics and Their Preparation
    Publication number: 20180235883
    Abstract: In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.
    Type: Application
    Filed: March 2, 2018
    Publication date: August 23, 2018
    Applicant: Veiled Therapeutics LLC
    Inventors: James D. McChesney, Igor Nikoulin, Steve J. Bannister, Douglas L. Rodenburg
  • SOLUBILIZATION OF PTEROSTILBENE AND RESVERATROL FOR AQUEOUS BEVERAGES
    Publication number: 20180127344
    Abstract: In one embodiment, the present application discloses compositions and methods of solubilizing pterostilbene or resveratrol, or mixture thereof in aqueous media.
    Type: Application
    Filed: January 10, 2018
    Publication date: May 10, 2018
    Applicant: Ironstone Separations, Inc.
    Inventors: James D. McChesney, Igor Nikoulin, Douglas L. Rodenburg
  • Solubilization of pterostilbene and resveratrol in aqueous beverages
    Patent number: 9896403
    Abstract: In one embodiment, the present application discloses compositions and methods of solubilizing pterostilbene or resveratrol, or mixture thereof in aqueous media.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: February 20, 2018
    Assignee: Ironstone Separations, Inc.
    Inventors: James D. McChesney, Igor Nikoulin, Douglas L. Rodenburg
  • Nanoparticulate Compositions for Targeted Delivery of Acid Labile, Lipophilic Prodrugs of Cancer Chemotherapeutics and Their Preparation
    Publication number: 20170042815
    Abstract: In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.
    Type: Application
    Filed: August 22, 2016
    Publication date: February 16, 2017
    Applicant: Arbor Therapeutics, LLC
    Inventors: James D. McChesney, Igor Nikoulin, Steve J. Bannister, Douglas L. Rodenburg
  • Nanoparticulate compositions for targeted delivery of acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation
    Patent number: 9468603
    Abstract: In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.
    Type: Grant
    Filed: September 13, 2014
    Date of Patent: October 18, 2016
    Assignee: ARBOR THERAPEUTICS, LLC
    Inventors: James D. McChesney, Igor Nikoulin, Steve J. Bannister, Douglas L. Rodenburg
  • Solubilization of Pterostilbene and Resveratrol in Aqueous Beverages
    Publication number: 20160052850
    Abstract: In one embodiment, the present application discloses compositions and methods of solubilizing pterostilbene or resveratrol, or mixture thereof in aqueous media.
    Type: Application
    Filed: August 22, 2014
    Publication date: February 25, 2016
    Applicant: Ironstone Separations, Inc.
    Inventors: James D. McChesney, Igor Nikoulin, Douglas L. Rodenburg
  • Nanoparticulate Compositions for Targeted Delivery of Acid Labile, Lipophilic Prodrugs of Cancer Chemotherapeutics and Their Preparation
    Publication number: 20150079189
    Abstract: In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.
    Type: Application
    Filed: September 13, 2014
    Publication date: March 19, 2015
    Applicant: Arbor Therapeutics, LLC
    Inventors: James D. McChesney, Igor Nikoulin, Steve J. Bannister, Douglas L. Rodenburg
  • Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
    Publication number: 20070004644
    Abstract: The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of hypercholesterolemia, atherosclerosis and associated cardiovascular diseases.
    Type: Application
    Filed: June 9, 2005
    Publication date: January 4, 2007
    Inventors: Jagadish Sircar, Victor Vassar, Kashinatham Alisala, Igor Nikoulin
  • Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
    Publication number: 20060166891
    Abstract: The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of hypercholesterolemia, atherosclerosis and associated cardiovascular diseases.
    Type: Application
    Filed: April 22, 2004
    Publication date: July 27, 2006
    Inventors: Jagadish Sircar, Kashinatham Alisala, Igor Nikoulin
  • Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
    Publication number: 20060009487
    Abstract: The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of hypercholesterolemia, atherosclerosis and associated cardiovascular diseases.
    Type: Application
    Filed: June 9, 2005
    Publication date: January 12, 2006
    Inventors: Jagadish Sircar, Richard Thomas, Haripada Khatuya, Igor Nikoulin
  • Small molecules for treatment of hypercholesterolemia and related diseases
    Publication number: 20050277690
    Abstract: The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of hypercholesterolemia, atherosclerosis and associated cardiovascular diseases.
    Type: Application
    Filed: June 9, 2005
    Publication date: December 15, 2005
    Inventors: Jagadish Sircar, Haripada Khatuya, Richard Thomas, Kashinatham Alisala, Victor Vassar, Igor Nikoulin
  • Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
    Publication number: 20050159362
    Abstract: The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of disease conditions associated with hypercholesterolemia.
    Type: Application
    Filed: October 27, 2004
    Publication date: July 21, 2005
    Inventors: Jagadish Sircar, Kashinatham Alisala, Igor Nikoulin