Patents by Inventor Igor Polikarpov

Igor Polikarpov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL NADH-DEPENDENT ENZYME MUTANTS TO CONVERT ACETONE INTO ISOPROPANOL
    Publication number: 20230279365
    Abstract: The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.
    Type: Application
    Filed: December 20, 2022
    Publication date: September 7, 2023
    Inventors: Verônica Leite QUEIROZ, Lucas Pedersen PARIZZI, Iuri Estrada GOUVEA, Debora Noma OKAMOTO, Rafael Victório Carvalho GUIDO, Alessandro Silva NASCIMENTO, Igor POLIKARPOV
  • NADH-dependent enzyme mutants to convert acetone into isopropanol
    Patent number: 11530391
    Abstract: The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: December 20, 2022
    Assignee: BRASKEM S.A.
    Inventors: Verônica Leite Queiroz, Lucas Pedersen Parizzi, Iuri Estrada Gouvea, Debora Noma Okamoto, Rafael Victório Carvalho Guido, Alessandro Silva Nascimento, Igor Polikarpov
  • NOVEL NADH-DEPENDENT ENZYME MUTANTS TO CONVERT ACETONE INTO ISOPROPANOL
    Publication number: 20190309266
    Abstract: The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.
    Type: Application
    Filed: April 8, 2019
    Publication date: October 10, 2019
    Inventors: Verônica Leite QUEIROZ, Lucas Pedersen PARIZZI, Iuri Estrada GOUVEA, Debora Noma OKAMOTO, Rafael Victório Carvalho GUIDO, Alessandro Silva NASCIMENTO, Igor POLIKARPOV
  • Crystal structure of interleukin-22 and uses thereof
    Publication number: 20040002586
    Abstract: This invention provides the three dimensional structure of human IL-22 and recombinant human IL-22 with mutations in the receptor binding regions and the dimerization interface and nucleic acid molecule encoding same. This invention also relates to methods of using pharmaceutical formulations and mimetics of the recombinant IL-22 and to methods for generating mutants based on the crystalline structure of IL-22.
    Type: Application
    Filed: September 10, 2002
    Publication date: January 1, 2004
    Inventors: Ronaldo A.P. Nagem, Igor Polikarpov, Jean Christophe Renauld, Didier Colau, Laure Dumoutier
  • Crystal structure of human interleukin-22
    Publication number: 20020187512
    Abstract: This invention provides the three dimensional structure of human IL-22 and recombinant human IL-22 with mutations in the receptor binding regions and the dimerization interface and nucleic acid molecule encoding same. This invention also relates to methods of using pharmaceutical formulations and mimetics of the recombinant IL-22 and to methods for generating mutants based on the crystalline structure of IL-22.
    Type: Application
    Filed: January 18, 2002
    Publication date: December 12, 2002
    Inventors: Ronaldo Alves Pinto Nagem, Igor Polikarpov, Jean Christophe Renauld, Didier Colau, Laure Dumoutier