Patents by Inventor Igor Rybkin

Igor Rybkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of protein kinase C-related kinase (PRK) as a treatment for cardiac hypertrophy and heart failure
    Publication number: 20050283841
    Abstract: The present invention provides for methods of treating and preventing cardiac hypertrophy and heart failure. MEF-2 and Class II HDACs have been shown to have a major role in cardiac hypertrophy and heart disease, and inhibition of class II HDAC's has been shown to have a beneficial, anti-hypertrophic effect. The present invention provides a link between MEF-2 and class II HDAC's, a kinase known as PRK. The present invention further demonstrates that inhibitors of PRK inhibit cardiac hypertrophy and heart disease by inhibiting, in part, the fetal cardiac gene expression and cellular reorganization that occurs when MEF-2 dependent transcription is activated.
    Type: Application
    Filed: February 2, 2005
    Publication date: December 22, 2005
    Inventors: Timothy McKinsey, Eric Olson, Brooke Harrison, Igor Rybkin, Steve Helmke