Abstract: The present disclosure pertains to computer-assisted search of image slices. In some embodiments, an image slice having a detected finding (and representing a cross section of at least a portion of an individual) may be determined. A search space may be reduce to a subset of image slices respectively representing a cross section corresponding to the cross section represented by the determined image slice. The search space reduction may comprise filtering a set of image slices based on the cross section represented by the determined image slice. Image slice information related to the determined image slice and related one or more image slices (of the image slices subset) may be obtained based on the search space reduction. A determination of whether indications of the detected finding exist in the image slices (of the image slices subset) may be effectuated based on the image slice information.