Patents by Inventor Igor Y. Goryshin

Igor Y. Goryshin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OLIGONUCLEOTIDE REPLACEMENT FOR DI-TAGGED AND DIRECTIONAL LIBRARIES
    Publication number: 20140031261
    Abstract: Transposomes and oligonucleotide replacement methods to make DNA libraries that have distinct 5? and 3? tags, and to make directional libraries that are enriched for a desired strand.
    Type: Application
    Filed: January 30, 2012
    Publication date: January 30, 2014
    Applicant: Illumina, Inc
    Inventors: Igor Y. Goryshin, Bradley Baas, Ramesh Vaidyanathan, Mark Maffitt
  • Method for making insertional mutations using a Tn5 synaptic complex
    Patent number: 6294385
    Abstract: A method for making insertional mutations at random or quasi-random locations in the chromosomal or extra-chromosomal nucleic acid of a target cell includes the step of combining, in the target cell, cellular nucleic acid with a synaptic complex that comprises (a) a transposase protein and (b) a polynucleotide that comprises (1) a pair of nucleotide sequences adapted for operably interacting with Tn5 transposase and (2) a transposable nucleotide sequence therebetween, under conditions that mediate transpositions into the cellular DNA. In the method, the synaptic complex is formed in vitro under conditions that disfavor or prevent the synaptic complexes from undergoing productive transposition.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: September 25, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor Y. Goryshin, William S. Reznikoff
  • Method for making insertional mutations using a Tn5 synaptic complex
    Patent number: 6159736
    Abstract: A method for making insertional mutations at random or quasi-random locations in the chromosomal or extra-chromosomal nucleic acid of a target cell includes the step of combining, in the target cell, cellular nucleic acid with a synaptic complex that comprises (a) a Tn5 transposase protein and (b) a polynucleotide that comprises a pair of nucleotide sequences adapted for operably interacting with Tn5 transposase and a transposable nucleotide sequence therebetween, under conditions that mediate transpositions into the cellular DNA. In the method, the synaptic complex is formed in vitro under conditions that disfavor or prevent the synaptic complexes from undergoing productive transposition.
    Type: Grant
    Filed: September 23, 1998
    Date of Patent: December 12, 2000
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: William S. Reznikoff, Igor Y. Goryshin