Abstract: Provided herein, in some embodiments, are methods for reducing the risk of developing progressive multifocal leukemia in patients undergoing natalizumab therapy by switching to an extended interval dosing (EID) schedule.

Abstract: The present invention relates to pentaerythritol derivatives represented by the following formula 1, which improve moisture retaining ability of the stratum corneum when show high moisturizing ability even in dry conditions, to a preparation method thereof, and to a liquid crystal base containing the same. (Wherein R is the same or different, saturated or unsaturated, linear or branched alkyl groups of 1 to 24 carbon atoms having hydrogen or hydroxy group or not; m and n are the same or different integers of which m is 0 to 10 and n is 1 to 10).

Abstract: The present invention relates to a water-in-oil-in-water multiple emulsion system and a method for preparation thereof, characterized by hydrodynamically stabilizing the multiple emulsion system by using hydrodynamic dual stabilization (HDS) technology. The HDS technology hydrophobizes water molecules in the internal aqueous phase by using a hydrogen bonding inhibitor and by improving the aggregating force between water molecules in the internal aqueous phase by using a water molecule aggregating agent.

Abstract: Conjugates of a biodegradable aliphatic polyester-based polymer with Tat49-57 peptide or a peptide chain containing the Tat49-57 peptide, and nanoparticles manufactured using the same. Intracellular permeability of the Tat49-57 peptide can be enhanced by exposing Tat peptide moieties to the surface of the nanoparticles.