Abstract: The present application provides a method inserting a S-Shape catheter to pulmonary artery of a person in need. Generally, the S-Shape catheter can be introduced through femoral vein or inferior vena cava; and then advanced through right atrium, right ventricle, and right ventricular outflow tract; and then advanced to the pulmonary artery through pulmonary valve.

Abstract: In some embodiments, after authentication of a user at a trusted device, a system may store a record with user or other support information and a code in a database. When support is requested by the user device, the code provided in response to the request (e.g., as an extension to a phone number or in a header field), and a system may use the code to retrieve the record from the database. Presence of the record in the database may indicate to the communication system that the user requesting support is already authenticated.

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract: The present invention is directed to cathepsin inhibitor conjugates, precursors and compositions comprising thereof. Further, methods of use such as for the treatment and prevention of a disorder associated with abnormal cathepsin activity in a subject in need thereof are also provided.

Abstract: Disclosed herein is a region-based reference management system using in video frame encoding. Source content, such as video game streaming or remote desktop sharing, that includes scene changes or significant instantaneous changes in a region from one frame to the next can present encoding challenges. Techniques disclosed herein use hints about changes in regional frame content, dissect frame content into regions, and associate the dissected regions with stored reference frame data using the hints and information about the regions to more efficiently encode frames.

Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: Techniques for customizing knowledge representation systems including identifying, based on a plurality of concepts in a knowledge representation (KR), a group of one or more concepts relevant to user context information, and providing the identified group of one more concepts to a user. The KR may include a combination of modules. The modules may include a kernel and a customized module customized for the user. The kernel may accessible via a second KR.

Abstract: Systems and methods are provided for generating training data for a machine-learning classifier. A knowledge representation synthesized based on an object of interest is used to assign labels to content items. The labeled content items can be used as training data for training a machine learning classifier. The labeled content items can also be used as validation data for the classifier.

Abstract: This document describes techniques directed to active thermal-control of a floodlight and associated floodlights. As described, an example floodlight includes a first heat-transfer subsystem that uses a fully enclosed heat sink to transfer heat from an array of LEDs to a first housing component of the floodlight. The floodlight further includes a second heat-transfer subsystem to transfer heat from one or more PSUs to a second housing component of the floodlight. Described techniques include using thermistors located throughout the floodlight to actively monitor a temperature profile within the floodlight and, if one or more operating-temperature thresholds are violated, reducing power consumption within the floodlight.

Abstract: A processing device includes an automated overclocking system and a processor. The automated overclocking system is data-driven and includes an inference engine that executes a machine learning model configured to generate a first output based on a current configuration of the processing device. The first output includes a first set of overclocking parameters. The processor is configured to adjust one or more operating characteristics of at least one component of the processing device based on the first set of overclocking parameters.

Abstract: Techniques for use in identifying one of more concepts in a knowledge representation (KR). The techniques include obtaining user context information associated with a user, wherein the user context information comprises a plurality of words; Also included are semantic disambiguation techniques comprising obtaining user context information associated with a user, wherein the user context information comprises a first portion and a second portion different from the first portion; and disambiguating between a first and second concept in a knowledge representation (KR) associated with a first meaning of the first portion. Semantic disambiguation techniques further include obtaining user context information associated with a user, wherein the user context information comprises a first portion and a second portion different from the first portion; and disambiguating between a first concept and second concept in a knowledge representation (KR) using a measures of dominance and semantic coherence.

Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The compounds may have a structure according to Formula I The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: A client-initiated low-latency network edge spectrum-as-a-service controller is described herein. A method as described herein can include transmitting, by a system comprising a processor to a first spectrum access system, a request for first access rights to a first spectrum band, wherein the first spectrum band is wholly contained within a second spectrum band for which the first spectrum access system is granted second access rights from a second spectrum access system, distinct from the first spectrum access system; obtaining, by the system, the first access rights to the first spectrum band from the first spectrum access system in response to the request; and, in response to obtaining the first access rights, initiating, by the system via the first spectrum band, a point-to-point communication link between the system and a user equipment.

Abstract: Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein A, X, Z, m, p, and R2 are as described herein. In certain embodiments, a compound disclosed herein inhibits the activity of one or more members of the TGF-? superfamily, and can be used to treat disease by blocking such activity.

Abstract: A low-latency network edge spectrum-as-a-service controller is described herein. A method as described herein can include acquiring, by a system comprising a processor from a spectrum access system, first access rights to a first spectrum band; determining, by the system, availability of a second spectrum band, wholly contained within the first spectrum band, in response to a request, received from network equipment of a radio access network, for second access rights to the second spectrum band; and, in response to the second spectrum band being determined to be available, granting, by the system, the second access rights to the second spectrum band to the network equipment.

Abstract: An apparatus and method for dispatching flash commands. The apparatus includes a plurality of queues, wherein each queue comprises an input to receive a flash command, an output to send a flash command, and an empty signal output to signal when the queue is empty, wherein each queue is assigned a unique, ordered priority. The apparatus includes a selector comprising a plurality of flash command inputs, a flash command output to a flash target, and a selection input, wherein each flash command input is coupled to a corresponding queue output. The apparatus includes an arbiter comprising inputs receiving each queue empty signal and receiving a lock bit from the flash command output of the selector and comprising a selection output coupled to the selection input of the selector. The flash command comprises a lock bit and a plurality of control bits to output to control inputs on a flash target.

Abstract: To leverage an amount of unused bandwidth at a hardware encoder to generate motion estimation data, a processing unit includes a hardware encoder configured to perform a first encoding job including encoder sessions to encode a captured frame, determine motion estimation data for a rendered frame, and encode the rendered frame. Further, the processing unit includes a pre-processing circuitry configured to determine a set of motion estimation parameters based on an encoder delay associated with the performance of the first encoding job by the hardware encoder. The hardware encoder is then configured to perform a second encoding job using the determined set of motion estimation parameters.

Abstract: This document describes a passive thermal-control system that can be integrated into an electronic speaker device and associated electronic speaker devices. The passive thermal-control system uses an architecture that combines heat spreaders and thermal interface materials to transfer heat from heat-generating electronic devices of the electronic speaker device to a housing component of the electronic speaker device. The housing component dissipates the heat to prevent a thermal runaway condition.

Abstract: A method for classifying network traffic includes accessing processed network data that includes multiple groups. Each group includes multiple URL data objects and is associated with an entity. The method includes generating a dynamic intent score for each group by generating a comparison value for each URL data object within a group, selecting highest comparison values for the URL data objects within the group, generating the dynamic intent score by averaging the selected highest comparison values, and ranking the groups according to their respective dynamic intent scores. The comparison value for each URL data object is generated by scraping a webpage associated with a URL data object to generate a first scraped text data object, creating web embeddings by providing the scraped text data object to a machine learning module, and generating a comparison value by comparing the web embeddings with reference embeddings.

Abstract: Aspects relate to a control system and method for a vehicle suspension system in a vehicle. The control system (100, 200) is configured to: receive a disturbance angle (316) of a roll bar of the vehicle suspension system, the disturbance angle indicative of a determined relative angular displacement between ends of the roll bar caused by the vehicle interacting with a driving surface; receive a displacement value (322) of an actuator motor of the actuator of the vehicle suspension system, the displacement value of the actuator motor indicative of a sensed displacement of the actuator motor caused by the vehicle interacting with the driving surface; determine, in dependence on the disturbance angle of the roll bar and the displacement value of the actuator motor, a torque estimation (332), the torque estimation representing an expected torque provided by the actuator motor to a roll bar connected to the actuator motor; and output the torque estimation to a further vehicle system.