Patents by Inventor Iiya Avrutov

Iiya Avrutov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel processes for making- and a new crystalline form of- leflunomide
    Publication number: 20050004191
    Abstract: New leflunomide Form III is disclosed, along with processes for preparing it. The present invention also provides an economic process for preparing leflunomide Form II and a process for preparing leflunomide Form I from leflunomide Form III. Pharmaceutical compositions and dosage forms containing the new form and methods of using them for the treatment of rheumatoid arthritis are also disclosed.
    Type: Application
    Filed: July 22, 2004
    Publication date: January 6, 2005
    Inventors: IIya Avrutov, Neomi Gershon, Judith Aronhime
  • Process for preparing leflunomide form I
    Patent number: 6806373
    Abstract: New leflunomide Form III is disclosed, along with processes for preparing it. The present invention also provides an economic process for preparing leflunomide Form II and a process for preparing leflunomide Form I from leflunomide Form III. Pharmaceutical compositions and dosage forms containing the new form and methods of using them for the treatment of rheumatoid arthritis are also disclosed.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: October 19, 2004
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Iiya Avrutov, Neomi Gershon, Judith Aronhime
  • Novel processes for making- and a new crystalline form of- leflunomide
    Publication number: 20030203952
    Abstract: New leflunomide Form III is disclosed, along with processes for preparing it. The present invention also provides an economic process for preparing leflunomide Form II and a process for preparing leflunomide Form I from leflunomide Form III. Pharmaceutical compositions and dosage forms containing the new form and methods of using them for the treatment of rheumatoid arthritis are also disclosed.
    Type: Application
    Filed: April 8, 2003
    Publication date: October 30, 2003
    Inventors: Iiya Avrutov, Neomi Gershon, Judith Aronhime
  • Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
    Patent number: 6617436
    Abstract: The present invention relates to processes for preparing protected silylated clarithromycin oxime, preferably 6-O-methyl-2′, 4″-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime (“S-MOP oxime”), and for converting protected silylated clarithromycin oxime, preferably S-MOP oxime, to clarithromycin. Processes for preparing protected silylated clarithromycin oxime according to the present invention, include reacting a silyl oxime derivative with methylating agent in the presence of at least one solvent and a base, where the solvent comprises methyl tertbutyl ether.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: September 9, 2003
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Iiya Avrutov, Igor Lifshitz, Elizabeth Lewiner
  • Process for preparing paroxetine HCl which limits formation of pink colored compounds
    Publication number: 20030083501
    Abstract: The present invention provides a process for preparing paroxetine HCl from paroxetine base which provides paroxetine HCl substantially free of pink-colored compounds or an impurity identified by an HPLC RRT of about 1.5. The processes of the present invention utilize a buffer, a molar ratio of HCl to paroxetine base of less than one, and crystallize/recrystallize in the presence of an effective amount of an anti-oxidants. A preferred way to create a buffer is by using ammonium chloride. A preferred anti-oxidant is ascorbic acid.
    Type: Application
    Filed: June 14, 2002
    Publication date: May 1, 2003
    Inventors: IIya Avrutov, Gideon Pilarsky