Abstract: A system, computer-readable storage medium and method for prognosis of head and neck cancer, includes an input for receiving electronic health records (EHR) of a patient, an input for receiving multimodal images of a head and neck area of the patient, a feature extraction module for converting the electronic health records and multimodal images into at least one feature vector, a hybrid machine learning architecture that includes a multi-task logistic regression (MTLR) model and a multi-layer artificial neural network, the hybrid architecture takes as input the at least one feature vector and outputs a final risk score of prognosis for head and neck cancer for the patient.