Patents by Inventor Ike W. Lee

Ike W. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Encapsulated cell indicator system
    Publication number: 20080145860
    Abstract: The invention features an encapsulated cell indicator system that includes (a) indicator cells having a signal-responsive element operably linked to a reporter gene; (b) encapsulating material; and (c) a permeable membrane. In this encapsulated cell indicator system, the indicator cells are encapsulated in the encapsulated material and the encapsulated material and the indicator cells are surrounded by the permeable membrane.
    Type: Application
    Filed: November 19, 2007
    Publication date: June 19, 2008
    Inventors: Ike W. Lee, Rabia Ballica, Jeffrey D. Croissant
  • Encapsulated cell indicator system
    Patent number: 7297538
    Abstract: The invention features an encapsulated cell indicator system that includes (a) indicator cells having a signal-responsive element operably linked to a reporter gene; (b) encapsulating material; and (c) a permeable membrane. In this encapsulated cell indicator system, the indicator cells are encapsulated in the encapsulated material and the encapsulated material and the indicator cells are surrounded by the permeable membrane.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: November 20, 2007
    Assignee: Cardio3 S.A.
    Inventors: Ike W. Lee, Jeffrey D. Croissant, Rabia Ballica
  • Cardiac-cell specific enhancer elements and uses thereof
    Publication number: 20040260079
    Abstract: The invention features cardiac cell-specific enhancer elements derived from Csx/Nkx2.5 regulatory regions. These enhancer elements are useful, for example, for (i) regulating gene expression in cardiac cells, (ii) inducing stem cells (e.g., embryonic stem cells or bone marrow stem cells) to differentiate as cardiomyocytes, and (iii) identifying factors that induce the differentiation of stem cells as cardiomyocytes.
    Type: Application
    Filed: February 17, 2004
    Publication date: December 23, 2004
    Inventors: Ike W. Lee, Seigo Izumo
  • Cardiac-cell specific enhancer elements and uses thereof
    Patent number: 6818757
    Abstract: The invention features cardiac cell-specific enhancer elements derived from Csx/Nkx2.5 regulatory regions. These enhancer elements are useful, for example, for (i) regulating gene expression in cardiac cells, (ii) inducing stem cells (e.g., embryonic stem cells or bone marrow stem cells) to differentiate as cardiomyocytes, and (iii) identifying factors that induce the differentiation of stem cells as cardiomyocytes.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: November 16, 2004
    Assignee: Beth Israel Deaconess Medical Center
    Inventors: Ike W. Lee, Seigo Izumo
  • Methods and reagents for cell transplantation
    Publication number: 20030031651
    Abstract: The invention features methods for producing cells for transplantation into myocardial tissue of a mammal (e.g., a human). The method includes the steps of (a) providing a population of bone marrow stem cells; (b) culturing the cells under conditions that induce the cells to become cardiomyogenic cells; (c) monitoring the state of differentiation of the cells of step (b); and (d) collecting the cells of step (b) when at least about 10% and as many as 100% of the cells are cardiomyogenic cells. The bone marrow stem cells can be, for example, human bone marrow stem cells. In one embodiment, the method includes the step of transplanting the differentiated stem cells into a mammal (e.g., a human).
    Type: Application
    Filed: April 12, 2002
    Publication date: February 13, 2003
    Inventors: Ike W. Lee, Guizhen Liu, James Hampe, Jeffrey D. Croissant
  • Encapsulated cell indicator system
    Publication number: 20030017510
    Abstract: The invention features an encapsulated cell indicator system that includes (a) indicator cells having a signal-responsive element operably linked to a reporter gene; (b) encapsulating material; and (c) a permeable membrane. In this encapsulated cell indicator system, the indicator cells are encapsulated in the encapsulated material and the encapsulated material and the indicator cells are surrounded by the permeable membrane.
    Type: Application
    Filed: April 12, 2002
    Publication date: January 23, 2003
    Inventors: Ike W. Lee, Rabia Ballica, Jeffrey D. Croissant
  • Cardiac-cell specific enhancer elements and uses thereof
    Publication number: 20020022259
    Abstract: The invention features cardiac cell-specific enhancer elements derived from Csx/Nkx2.5 regulatory regions. These enhancer elements are useful, for example, for (i) regulating gene expression in cardiac cells, (ii) inducing stem cells (e.g., embryonic stem cells or bone marrow stem cells) to differentiate as cardiomyocytes, and (iii) identifying factors that induce the differentiation of stem cells as cardiomyocytes.
    Type: Application
    Filed: January 16, 2001
    Publication date: February 21, 2002
    Inventors: Ike W. Lee, Seigo Izumo