Patents by Inventor Iker Valle Aramburu

Iker Valle Aramburu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTIPLE CYCLOADDITION REACTIONS FOR LABELING OF MOLECULES
    Publication number: 20200231539
    Abstract: The present invention relates to methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-labeling strategies. In particular, the invention relates to methods for forming linkages by cycloaddition reactions, wherein the method comprises reacting a first alkyl-substituted tetrazine with a first dienophile comprising a irans-cyclooctenyl group followed by reacting a second tetrazine with a second dienophile comprising a cyclooctynyl group, wherein the reaction of the first tetrazine with the first dienophile proceeds in the presence of the second dienophile.
    Type: Application
    Filed: November 22, 2019
    Publication date: July 23, 2020
    Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY
    Inventors: Edward Lemke, Carsten Schultz, Tilman Plass, Ivana Nikic, Jan-Erik Hoffmann, Iker Valle Aramburu
  • Trans-cyclooctene amino and hydroxy acids and their use in multiple cycloaddition reactions for labeling of molecules
    Patent number: 10519101
    Abstract: The present invention relates to compounds of formula: and methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-labeling strategies. In particular, the invention relates to methods for forming linkages by cycloaddition reactions, wherein the method comprises reacting a first alkyl-substituted tetrazine with a first dienophile comprising a trans-cyclooctenyl group followed by reacting a second tetrazine with a second dienophile comprising a cyclooctynyl group, wherein the reaction of the first tetrazine with the first dienophile proceeds in the presence of the second dienophile.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: December 31, 2019
    Assignee: European Molecular Biology Laboratory
    Inventors: Edward Lemke, Carsten Schultz, Tilman Plass, Ivana Nikic, Jan-Erik Hoffmann, Iker Valle Aramburu
  • MULTIPLE CYCLOADDITION REACTIONS FOR LABELING OF MOLECULES
    Publication number: 20160340297
    Abstract: The present invention relates to methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-labeling strategies. In particular, the invention relates to methods for forming linkages by cycloaddition reactions, wherein the method comprises reacting a first alkyl-substituted tetrazine with a first dienophile comprising a irans-cyclooctenyl group followed by reacting a second tetrazine with a second dienophile comprising a cyclooctynyl group, wherein the reaction of the first tetrazine with the first dienophile proceeds in the presence of the second dienophile.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 24, 2016
    Inventors: Edward Lemke, Carsten Schultz, Tillmann Plass, Ivana Nikic, Jan-Erik Hoffmann, Iker Valle Aramburu